Interleukin-4 activated macrophages mediate immunity to filarial helminth infection by sustaining CCR3-dependent eosinophilia.

Autor: Joseph D Turner, Nicolas Pionnier, Julio Furlong-Silva, Hanna Sjoberg, Stephen Cross, Alice Halliday, Ana F Guimaraes, Darren A N Cook, Andrew Steven, Nico Van Rooijen, Judith E Allen, Stephen J Jenkins, Mark J Taylor

Publikováno v: PLoS Pathogens, Vol 14, Iss 3, p e1006949 (2018)

Eosinophils are effectors in immunity to tissue helminths but also induce allergic immunopathology. Mechanisms of eosinophilia in non-mucosal tissues during infection remain unresolved. Here we identify a pivotal function of tissue macrophages (Mϕ)

Externí odkaz: https://doaj.org/article/89105a4f1ac8479982a358d3bd651ce1

Macrophage origin limits functional plasticity in helminth-bacterial co-infection.

Autor: Dominik Rückerl, Sharon M Campbell, Sheelagh Duncan, Tara E Sutherland, Stephen J Jenkins, James P Hewitson, Tom A Barr, Lucy H Jackson-Jones, Rick M Maizels, Judith E Allen

Publikováno v: PLoS Pathogens, Vol 13, Iss 3, p e1006233 (2017)

Rapid reprogramming of the macrophage activation phenotype is considered important in the defense against consecutive infection with diverse infectious agents. However, in the setting of persistent, chronic infection the functional importance of macr

Externí odkaz: https://doaj.org/article/13c5789c28094405a1f784be2bdd5dc5

Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation

Autor: Ananda S. Mirchandani, Stephen J. Jenkins, Calum C. Bain, Manuel A. Sanchez-Garcia, Hannah Lawson, Patricia Coelho, Fiona Murphy, David M. Griffith, Ailiang Zhang, Tyler Morrison, Tony Ly, Simone Arienti, Pranvera Sadiku, Emily R. Watts, Rebecca. S. Dickinson, Leila Reyes, George Cooper, Sarah Clark, David Lewis, Van Kelly, Christos Spanos, Kathryn M. Musgrave, Liam Delaney, Isla Harper, Jonathan Scott, Nicholas J. Parkinson, Anthony J. Rostron, J. Kenneth Baillie, Sara Clohisey, Clare Pridans, Lara Campana, Philip Starkey Lewis, A. John Simpson, David H. Dockrell, Jürgen Schwarze, Nikhil Hirani, Peter J. Ratcliffe, Christopher W. Pugh, Kamil Kranc, Stuart J. Forbes, Moira K. B. Whyte, Sarah R. Walmsley

Publikováno v: Mirchandani, A S, Jenkins, S J, Bain, C C, Sanchez Garcia, M A, Lawson, H, Coelho, P, Murphy, F, Griffith, D, Zhang, A, Morrison, T, Ly, T, Arienti, S, Sadiku, P, Watts, E R, Dickinson, R, Reyes, L, Cooper, G, Clark, S, Lewis, D, Kelly, V, Spanos, C, Musgrave, K M, Delaney, L, Harper, I, Scott, J, Parkinson, N, Rostron, A J, Baillie, J K, Clohisey, S, Pridans, C, Campana, L, Starkey Lewis, P, Simpson, A J, Dockrell, D H, Schwarze, J, Hirani, N, Ratcliffe, P J, Pugh, C W, Kranc, K, Forbes, S J, Whyte, M K B & Walmsley, S R 2022, ' Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation ', Nature Immunology . https://doi.org/0.1038/s41590-022-01216-z

Hypoxemia is a defining feature of acute respiratory distress syndrome (ARDS), an often-fatal complication of pulmonary or systemic inflammation, yet the resulting tissue hypoxia, and its impact on immune responses, is often neglected. In the present

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09ab39b51379ba91e60afdc26dc1fbd1
https://doi.org/10.1038/s41590-022-01216-z

Immunology of a unique biological structure:The echinococcus laminated layer

Autor: Álvaro Díaz, Anabella A Barrios, Leticia Grezzi, Camila Mouhape, Stephen J Jenkins, Judith E Allen, Cecilia Casaravilla

Publikováno v: Díaz, Á, Barrios, A A, Grezzi, L, Mouhape, C, Jenkins, S J, Allen, J E & Casaravilla, C 2023, ' Immunology of a unique biological structure : The echinococcus laminated layer ', Protein & cell, vol. 14, no. 2, pp. 87-104 . https://doi.org/10.1093/procel/pwac023

The larval stages of the cestode parasites belonging to the genus Echinococcus grow within internal organs of humans and a range of animal species. The resulting diseases, collectively termed echinococcoses, include major neglected tropical diseases

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d0b7176af4e96e45b98bca298c3bab2
https://hdl.handle.net/20.500.11820/3c6c5fae-ecf7-491b-8e2e-8ebd55a7d202

CD11c identifies microbiota and EGR2-dependent MHCII+ serous cavity macrophages with sexually dimorphic fate in mice

Autor: Calum C. Bain, Pieter A. Louwe, Nicholas J. Steers, Alberto Bravo‐Blas, Lizi M. Hegarty, Clare Pridans, Simon W.F. Milling, Andrew S. MacDonald, Dominik Rückerl, Stephen J. Jenkins

Publikováno v: Bain, C C, Louwe, P A, Steers, N, Bravo-Blas, A, Hegarty, L, Pridans, C, Milling, S, MacDonald, A S, Ruckerl, D & Jenkins, S J 2022, ' CD11c identifies microbiota and EGR2-dependent MHCII+ serous cavity macrophages with sexually dimorphic fate in mice ', European Journal of Immunology, vol. 52, no. 8, pp. 1243-1257 . https://doi.org/10.1002/eji.202149756
Bain, C C, Louwe, P A, Steers, N J, Bravo-Blas, A, Hegarty, L M, Pridans, C, Milling, S W F, MacDonald, A S, Rückerl, D & Jenkins, S J 2022, ' CD11c identifies microbiota and EGR2-dependent MHCII+ serous cavity macrophages with sexually dimorphic fate in mice ', European journal of immunology . https://doi.org/10.1002/eji.202149756

The murine serous cavities contain a rare and enigmatic population of short-lived F4/80 loMHCII + macrophages but what regulates their development, survival, and fate is unclear. Here, we show that mature F4/80 loMHCII + peritoneal macrophages arise

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2ff8dc24f598395d90d3549f866efb6
https://www.pure.ed.ac.uk/ws/files/290984053/Eur_J_Immunol_2022_Bain_CD11c_identifies_microbiota_and_EGR2_u2010dependent_MHCII_serous_cavity_macrophages_with_sexually.pdf