Zobrazeno 1 - 10
of 657
pro vyhledávání: '"Stephen J Benkovic"'
Publikováno v:
eLife, Vol 5 (2016)
Translesion DNA synthesis (TLS) during S-phase uses specialized TLS DNA polymerases to replicate a DNA lesion, allowing stringent DNA synthesis to resume beyond the offending damage. Human TLS involves the conjugation of ubiquitin to PCNA clamps enci
Externí odkaz:
https://doaj.org/article/2233c422a7634f74948c648d7cfa0a9f
Autor:
Xiang Feng, Michelle M. Spiering, Ruda de Luna Almeida Santos, Stephen J. Benkovic, Huilin Li
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract The T4 bacteriophage gp41 helicase and gp61 primase assemble into a primosome to couple DNA unwinding with RNA primer synthesis for DNA replication. How the primosome is assembled and how the primer length is defined are unclear. Here we rep
Externí odkaz:
https://doaj.org/article/65c6a9d0bd20462fb5a359252ed1232a
Autor:
Qian Ma, Qiuhua Yang, Jiean Xu, Hunter G Sellers, Zach L Brown, Zhiping Liu, Zsuzsanna Bordan, Xiaofan Shi, Dingwei Zhao, Yongfeng Cai, Vidhi Pareek, Chunxiang Zhang, Guangyu Wu, Zheng Dong, Alexander D Verin, Lin Gan, Quansheng Du, Stephen J Benkovic, Suowen Xu, John M Asara, Issam Ben-Sahra, Scott Barman, Yunchao Su, David J R Fulton, Yuqing Huo
Publikováno v:
European Heart Journal. 44:1265-1279
Aims Proliferation of vascular smooth muscle cells (VSMCs) is a hallmark of pulmonary hypertension (PH). Proliferative cells utilize purine bases from the de novo purine synthesis (DNPS) pathways for nucleotide synthesis; however, it is unclear wheth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9329c8bdebe442e7d6f812bed7c84572
https://doi.org/10.1093/eurheartj/ehad044
https://doi.org/10.1093/eurheartj/ehad044
Autor:
Qian Ma, Qiuhua Yang, Jiean Xu, Xiaoyu Zhang, David Kim, Zhiping Liu, Qingen Da, Xiaoxiao Mao, Yaqi Zhou, Yongfeng Cai, Vidhi Pareek, Ha Won Kim, Guangyu Wu, Zheng Dong, Wen-Liang Song, Lin Gan, Chunxiang Zhang, Mei Hong, Stephen J. Benkovic, Neal L. Weintraub, David Fulton, John M. Asara, Issam Ben-Sahra, Yuqing Huo
Publikováno v:
Circulation. 146:1444-1460
Background: Proliferation of vascular smooth muscle cells (VSMCs) is a hallmark of arterial diseases, especially in arterial restenosis after angioplasty or stent placement. VSMCs reprogram their metabolism to meet the increased requirements of lipid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5565f06c97fa4a77b2181d860724fa0
https://doi.org/10.1161/circulationaha.121.058901
https://doi.org/10.1161/circulationaha.121.058901
Publikováno v:
Annu Rev Biochem
Over the past fifteen years, we have unveiled a new mechanism by which cells achieve greater efficiency in de novo purine biosynthesis. This mechanism relies on the compartmentalization of de novo purine biosynthetic enzymes into a dynamic complex ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::333c844e34da5823e95012cd5f497755
https://doi.org/10.1146/annurev-biochem-032620-105728
https://doi.org/10.1146/annurev-biochem-032620-105728
Publikováno v:
Viruses, Vol 7, Iss 6, Pp 3186-3200 (2015)
The T4 bacteriophage encodes eight proteins, which are sufficient to carry out coordinated leading and lagging strand DNA synthesis. These purified proteins have been used to reconstitute DNA synthesis in vitro and are a well-characterized model syst
Externí odkaz:
https://doaj.org/article/a17136f819464d4abcee7a0f63ea24a7
Publikováno v:
Mol Cell
With the elucidation of a myriad anabolic and catabolic enzyme-catalyzed cellular pathways crisscrossing each other, an obvious question arose – how could these networks operate with maximal catalytic efficiency and minimal interference? A logical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08b1b362cd92c0a452704a36bd994200
https://doi.org/10.1016/j.molcel.2021.08.030
https://doi.org/10.1016/j.molcel.2021.08.030
Publikováno v:
The Journal of biological chemistry. 298(5)
There is growing evidence that mammalian cells deploy a mitochondria-associated metabolon called the purinosome to perform channeled de novo purine biosynthesis (DNPB). However, the molecular mechanisms of this substrate-channeling pathway are not we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea2a1c099dc8b0d0d365d16ab6f27c1
https://pubmed.ncbi.nlm.nih.gov/35331738
https://pubmed.ncbi.nlm.nih.gov/35331738
Publikováno v:
J Mol Biol
Sliding clamp proteins encircle duplex DNA and are involved in processive DNA replication and the DNA damage response. Clamp proteins are ring-shaped oligomers (dimers or trimers) and are loaded onto DNA by an ATP-dependent clamp-loader complex that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8bd4d0f6b8222c6c0b1dd55ef61804e
https://doi.org/10.1016/j.jmb.2019.04.035
https://doi.org/10.1016/j.jmb.2019.04.035
Autor:
Chunliang Liu, Lewis C. Cantley, Jingxuan He, Giselle M. Knudsen, Stephen J. Benkovic, Tomer M. Yaron, Anthony M. Pedley, Jared L. Johnson
Publikováno v:
J Proteome Res
Purines represent a class of essential metabolites produced by the cell to maintain cellular homeostasis and facilitate cell proliferation. In times of high purine demand, the de novo purine biosynthetic pathway is activated; however, the mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de31af16aa6c3169bcde8f4b3917cd7f
https://doi.org/10.1021/acs.jproteome.8b00969
https://doi.org/10.1021/acs.jproteome.8b00969