Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Stephen J, Renaud"'
Autor:
Mariyan J. Jeyarajah, Violet S. Patterson, Gargi Jaju Bhattad, Lin Zhao, Shawn N. Whitehead, Stephen J. Renaud
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract Congenital heart defects are leading causes of neonatal mortality and are often associated with placental abnormalities, but mechanisms linking placenta and heart development are poorly understood. Herein, we investigated a potential signali
Externí odkaz:
https://doaj.org/article/6a1a723dd94140c984e20c6725f39a69
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Introduction: Uterine Natural Killer (NK) cells are the predominant immune cells within the decidua during early pregnancy. These cells are thought to regulate aspects of decidualization and placental development, but their functions remain poorly ch
Externí odkaz:
https://doaj.org/article/9d5d820bc2634236a900f90bcd2e425e
Autor:
Faraj L. Haddad, Salonee V. Patel, Ella E. Doornaert, Cleusa De Oliveira, Brian L. Allman, Kelly J. Baines, Stephen J. Renaud, Susanne Schmid
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 23, Iss , Pp 100473- (2022)
Maternal infections during pregnancy are linked with an increased risk for disorders like Autism Spectrum Disorder and schizophrenia in the offspring. Although precise mechanisms are still unclear, clinical and preclinical evidence suggest a strong r
Externí odkaz:
https://doaj.org/article/256e1779876f47988ad31827df9f7c3a
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Proper development of the placenta is vital for pregnancy success. The placenta regulates exchange of nutrients and gases between maternal and fetal blood and produces hormones essential to maintain pregnancy. The placental cell lineage primarily res
Externí odkaz:
https://doaj.org/article/d14055c7054f4e2fba9c233ec5339ed8
Autor:
Kelly J. Baines, Dendra M. Hillier, Faraj L. Haddad, Nagalingam Rajakumar, Susanne Schmid, Stephen J. Renaud
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Maternal immune activation (MIA) caused by exposure to pathogens or inflammation during critical periods of neurodevelopment is a major risk factor for behavioral deficits and psychiatric illness in offspring. A spectrum of behavioral abnormalities c
Externí odkaz:
https://doaj.org/article/835f45970c0d4102a0a0738de4eb77a5
Autor:
L. Rhiannon Hilton, Matthew T. Rätsep, M. Martin VandenBroek, Salema Jafri, Kimberly J. Laverty, Melissa Mitchell, Anne L. Theilmann, James A. Smart, Lindsey G. Hawke, Stephen D. Moore, Stephen J. Renaud, Michael J. Soares, Nicholas W. Morrell, Mark L. Ormiston
Publikováno v:
Hypertension. 79:2493-2504
Background: Natural killer (NK) cell impairment is a feature of pulmonary arterial hypertension (PAH) and contributes to vascular remodeling in animal models of disease. Although mutations in BMPR2 , the gene encoding the BMP (bone morphogenetic prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98544049ff5adf23b580ed6a7ef43152
https://doi.org/10.1161/hypertensionaha.122.19178
https://doi.org/10.1161/hypertensionaha.122.19178
Autor:
Adam Jaremek, Sumaiyah Shaha, Mariyan J. Jeyarajah, Gargi Jaju Bhattad, Diba Chowdhury, Meghan Riddell, Stephen J. Renaud
Publikováno v:
The American Journal of Pathology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8fe805a547d6a87188eaa898a00da3c
https://doi.org/10.1016/j.ajpath.2023.03.006
https://doi.org/10.1016/j.ajpath.2023.03.006
Publikováno v:
Cells, Vol 9, Iss 4, p 840 (2020)
Trophoblasts are the first cell type to be specified during embryogenesis, and they are essential for placental morphogenesis and function. Trophoblast stem (TS) cells are the progenitor cells for all trophoblast lineages; control of TS cell differen
Externí odkaz:
https://doaj.org/article/8bb8688f5607448188b9ea20abc2a585
Autor:
Mariyan J. Jeyarajah, Gargi Jaju Bhattad, Rachel D. Kelly, Kelly J. Baines, Adam Jaremek, Fei-Hung P. Yang, Hiroaki Okae, Takahiro Arima, Vanessa Dumeaux, Stephen J. Renaud
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(49)
Remodeling of the uterine vasculature by invasive extravillous trophoblasts (EVTs) is a critical aspect of human placentation. Insufficient EVT invasion can lead to severe obstetrical complications like preeclampsia, intrauterine growth restriction,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3f910ce9ce26d48b758305c4fb7e0f2
https://pubmed.ncbi.nlm.nih.gov/36442132
https://pubmed.ncbi.nlm.nih.gov/36442132
Publikováno v:
Paediatrics Publications
Mol Hum Reprod
Mol Hum Reprod
A critical component of early human placental development includes migration of extravillous trophoblasts (EVTs) into the decidua. EVTs migrate toward, and displace vascular smooth muscle cells (SMCs) surrounding several uterine structures, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::add428a3d955bd0f1b31968efa47cc7b
https://doi.org/10.1093/molehr/gaaa061
https://doi.org/10.1093/molehr/gaaa061