Zobrazeno 1 - 10
of 268
pro vyhledávání: '"Stephen J, Polyak"'
Autor:
Shadisadat Esmaeili, Katherine Owens, Jessica Wagoner, Stephen J. Polyak, Judith M. White, Joshua T. Schiffer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract In a pivotal trial (EPIC-HR), a 5-day course of oral ritonavir-boosted nirmatrelvir, given early during symptomatic SARS-CoV-2 infection (within three days of symptoms onset), decreased hospitalization and death by 89.1% and nasal viral load
Externí odkaz:
https://doaj.org/article/a3c14c64f2be4649b856e144e4a66648
Autor:
Jessica Wagoner, Shawn Herring, Tien-Ying Hsiang, Aleksandr Ianevski, Scott B. Biering, Shuang Xu, Markus Hoffmann, Stefan Pöhlmann, Michael Gale, Tero Aittokallio, Joshua T. Schiffer, Judith M. White, Stephen J. Polyak
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 5 (2022)
ABSTRACT Three directly acting antivirals (DAAs) demonstrated substantial reduction in COVID-19 hospitalizations and deaths in clinical trials. However, these agents did not completely prevent severe illness and are associated with cases of rebound i
Externí odkaz:
https://doaj.org/article/9c609e33ab9f488ab9c4badf3f7caa97
Autor:
Daniel Stone, Kelly R. Long, Michelle A. Loprieno, Harshana S. De Silva Feelixge, Elizabeth J. Kenkel, R. Matt Liley, Stephen Rapp, Pavitra Roychoudhury, Thuy Nguyen, Laurence Stensland, Rossana Colón-Thillet, Lindsay M. Klouser, Nicholas D. Weber, Connie Le, Jessica Wagoner, Erin A. Goecker, Alvason Zhenhua Li, Karsten Eichholz, Lawrence Corey, D. Lorne Tyrrell, Alexander L. Greninger, Meei-Li Huang, Stephen J. Polyak, Martine Aubert, John E. Sagartz, Keith R. Jerome
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss , Pp 258-275 (2021)
Chronic hepatitis B virus (HBV) infection is a major public health problem. New treatment approaches are needed because current treatments do not target covalently closed circular DNA (cccDNA), the template for HBV replication, and rarely clear the v
Externí odkaz:
https://doaj.org/article/50136f1751074d8594ac5811c80e88ea
Autor:
Aleksandr Ianevski, Rouan Yao, Ronja M. Simonsen, Vegard Myhre, Erlend Ravlo, Gerda D. Kaynova, Eva Zusinaite, Judith M. White, Stephen J. Polyak, Valentyn Oksenych, Marc P. Windisch, Qiuwei Pan, Eglė Lastauskienė, Astra Vitkauskienė, Algimantas Matukevičius, Tanel Tenson, Magnar Bjørås, Denis E. Kainov
Publikováno v:
iScience, Vol 25, Iss 4, Pp 104112- (2022)
Summary: Broadly effective antiviral therapies must be developed to be ready for clinical trials, which should begin soon after the emergence of new life-threatening viruses. Here, we pave the way towards this goal by reviewing conserved druggable vi
Externí odkaz:
https://doaj.org/article/77ed5cbd497a44c69e58bc71d4d6eb97
Autor:
Xia Wu, Jessica B. Roberto, Allison Knupp, Alexander L. Greninger, Camtu D. Truong, Nicole Hollingshead, Heidi L. Kenerson, Marianne Tuefferd, Antony Chen, David M. Koelle, Helen Horton, Keith R. Jerome, Stephen J. Polyak, Raymond S. Yeung, Ian N. Crispe
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Precision-cut human liver slice cultures (PCLS) have become an important alternative immunological platform in preclinical testing. To further evaluate the capacity of PCLS, we investigated the innate immune response to TLR3 agonist (poly-I:C) and TL
Externí odkaz:
https://doaj.org/article/75336c7dd31743c385e9d9eee84beec0
Autor:
Judith M. White, Joshua T. Schiffer, Rachel A. Bender Ignacio, Shuang Xu, Denis Kainov, Aleksandr Ianevski, Tero Aittokallio, Matthew Frieman, Gene G. Olinger, Stephen J. Polyak
Publikováno v:
mBio, Vol 12, Iss 6 (2021)
ABSTRACT The world was unprepared for coronavirus disease 2019 (COVID-19) and remains ill-equipped for future pandemics. While unprecedented strides have been made developing vaccines and treatments for COVID-19, there remains a need for highly effec
Externí odkaz:
https://doaj.org/article/ab7ef23eaa6841f3946431766ef6f980
Autor:
Aswad Khadilkar, Zoie L. Bunch, Jessica Wagoner, Vandana Ravindran, Jessica M. Oda, Warren S. Vidar, Trevor N. Clark, Preston K. Manwill, Daniel A. Todd, Sarah A. Barr, Lauren K. Olinger, Susan L. Fink, Wendy K. Strangman, Roger G. Linington, John B. MacMillan, Nadja B. Cech, Stephen J. Polyak
Publikováno v:
Journal of Natural Products. 86:1061-1073
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa58c664fb3796da97d052147ea20c6e
https://doi.org/10.1021/acs.jnatprod.3c00159
https://doi.org/10.1021/acs.jnatprod.3c00159
Autor:
Tecla M. Temu, Stephen J. Polyak, Celestine N. Wanjalla, Nelson Aringo Mandela, Smritee Dabee, Jerusha N. Mogaka, Sarah Masyuko, Chris Longernecker, Saate Shakil, Bhavna Chohan, Stephanie T. Page, Sylvia M. Lacourse, Bernard Gitura, Kristina Crothers, Julius Oyugi, Heather Jaspan, Carey Farquhar, Jerry S. Zifodya
Publikováno v:
AIDS. 37:1065-1075
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31c568002872f066f5096781ef79eb78
https://doi.org/10.1097/qad.0000000000003523
https://doi.org/10.1097/qad.0000000000003523
Publikováno v:
Pathogens, Vol 10, Iss 1, p 44 (2021)
Chronic hepatitis C (CHC) is a major cause of hepatocellular carcinoma (HCC) worldwide. While directly acting antiviral (DAA) drugs are now able to cure virtually all hepatitis C virus (HCV) infections, even in subjects with advanced liver disease, w
Externí odkaz:
https://doaj.org/article/cd21dff65eec4b82b6f2f5c31fbd2ce1
Autor:
Erica S. Lovelace, Stephen J. Polyak
Publikováno v:
Viruses, Vol 7, Iss 12, Pp 6218-6232 (2015)
Chronic viral infections like those caused by hepatitis C virus (HCV) and human immunodeficiency virus (HIV) cause disease that establishes an ongoing state of chronic inflammation. While there have been tremendous improvements towards curing HCV wit
Externí odkaz:
https://doaj.org/article/e47a349aaa9143af95b7718c469e2437