Zobrazeno 1 - 10
of 607
pro vyhledávání: '"Stephen J, Pandol"'
Autor:
Nurshad Ali, Silvana Debernardi, Evelyn Kurotova, Jian Tajbakhsh, Nirdesh K. Gupta, Stephen J. Pandol, Patrick Wilson, Stephen P. Pereira, Bill Greenhalf, Oleg Blyuss, Tatjana Crnogorac-Jurcevic
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer-related death worldwide. Up to now, no specific screening or diagnostic tests are available for early PDAC detection. As a result, most patients are diagnosed with advance
Externí odkaz:
https://doaj.org/article/10656395436a4094a4771fd148554943
Promoter Methylation Leads to Hepatocyte Nuclear Factor 4A Loss and Pancreatic Cancer Aggressiveness
Autor:
Maria Hatziapostolou, Marina Koutsioumpa, Abed M. Zaitoun, Christos Polytarchou, Mouad Edderkaoui, Swapna Mahurkar-Joshi, Jayakumar Vadakekolathu, Daniel D'Andrea, Anna Rose Lay, Niki Christodoulou, Thuy Pham, Tung-On Yau, Christina Vorvis, Suchit Chatterji, Stephen J. Pandol, George A. Poultsides, David W. Dawson, Dileep N. Lobo, Dimitrios Iliopoulos
Publikováno v:
Gastro Hep Advances, Vol 3, Iss 5, Pp 687-702 (2024)
Background and Aims: Decoding pancreatic ductal adenocarcinoma heterogeneity and the consequent therapeutic selection remains a challenge. We aimed to characterize epigenetically regulated pathways involved in pancreatic ductal adenocarcinoma progres
Externí odkaz:
https://doaj.org/article/ed3b70b9de5c43699e1addca71804e12
Autor:
Jingyu An, Roma Kurilov, Teresa Peccerella, Frank Bergmann, Mouad Edderkaoui, Adrian Lim, Xu Zhou, Katrin Pfütze, Angela Schulz, Stephan Wolf, Kai Hu, Christoph Springfeld, Sadaf S. Mughal, Lenart Zezlina, Franco Fortunato, Georg Beyer, Julia Mayerle, Susanne Roth, Johannes Hulkkonen, Daniela Merz, Shigenori Ei, Arianeb Mehrabi, Martin Loos, Mohammed Al-Saeedi, Christoph W. Michalski, Markus W. Büchler, Thilo Hackert, Benedikt Brors, Stephen J. Pandol, Peter Bailey, John P. Neoptolemos
Publikováno v:
Translational Oncology, Vol 49, Iss , Pp 102109- (2024)
Background: Despite some recent advances, pancreatic ductal adenocarcinoma (PDAC) remains a growing oncological challenge. New drugs capable of targeting more than one oncogenic pathway may be one way to improve patient outcomes. This study character
Externí odkaz:
https://doaj.org/article/df5a8e4d1fe7474090e2aa259e799323
Publikováno v:
Smart Medicine, Vol 3, Iss 2, Pp n/a-n/a (2024)
Abstract The islet of Langerhans, functioning as a “mini organ”, plays a vital role in regulating endocrine activities due to its intricate structure. Dysfunction in these islets is closely associated with the development of diabetes mellitus (DM
Externí odkaz:
https://doaj.org/article/b3035b67b39f474dbe45717f11d80aff
Autor:
Gareth Pollin, Angela J. Mathison, Thiago M. de Assuncao, Anju Thomas, Atefeh Zeighami, Ann Salmonson, Hongfei Liu, Guillermo Urrutia, Pallavi Vankayala, Stephen J. Pandol, Johnny C. Hong, Michael T. Zimmermann, Juan Iovanna, Victor X. Jin, Raul Urrutia, Gwen Lomberk
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
Introduction: The Euchromatic Histone Methyl Transferase Protein 2 (EHMT2), also known as G9a, deposits transcriptionally repressive chromatin marks that play pivotal roles in the maturation and homeostasis of multiple organs. Recently, we have shown
Externí odkaz:
https://doaj.org/article/3ab3e4841b6348709cd8a96b6f115521
Autor:
Liang Qi, Bo‐Wen Duan, Hui Wang, Yan‐Jun Liu, Han Han, Meng‐Meng Han, Lei Xing, Hu‐Lin Jiang, Stephen J. Pandol, Ling Li
Publikováno v:
Advanced Science, Vol 11, Iss 19, Pp n/a-n/a (2024)
Abstract Pancreatic fibrosis (PF) is primarily characterized by aberrant production and degradation modes of extracellular matrix (ECM) components, resulting from the activation of pancreatic stellate cells (PSCs) and the pathological cross‐linking
Externí odkaz:
https://doaj.org/article/f55b8429f5cf4eb486e2d2cbd8cea183
Autor:
Esther Adeniran, Dhiraj Yadav, Stephen J. Pandol, Georgios I. Papachristou, James L. Buxbaum, Joseph R. Pisegna, Christie Y. Jeon
Publikováno v:
Gastro Hep Advances, Vol 3, Iss 1, Pp 61-63 (2024)
Externí odkaz:
https://doaj.org/article/b77f0f1ec7aa4714be1a1d6d64242841
Publikováno v:
Cancers, Vol 16, Iss 14, p 2537 (2024)
Background/Objectives: Perinatal exposure to malnutrition has been hypothesised to influence the development of young-onset cancer (≤50 years of age). This study aimed to determine if perinatal malnutrition in individuals exposed to the Great Famin
Externí odkaz:
https://doaj.org/article/6c5e2b83352a49b898dff8cc94a2285a
Autor:
Yaroslav Teper, Linda Ye, Richard T. Waldron, Aurelia Lugea, Xiaoying Sun, James Sinnett-Smith, Oscar J. Hines, Stephen J. Pandol, Enrique Rozengurt, Guido Eibl
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Pancreatic ductal adenocarcinoma (PDAC), a highly lethal disease with limited therapeutic options, may benefit from repurposing of FDA-approved drugs in preventive or interceptive strategies in high-risk populations. Previous animal studies
Externí odkaz:
https://doaj.org/article/6608e1bba2a74358ac50303e509a41fb
Autor:
Suzanne Mashtoub, Shahid Ullah, Anne Collinson, Gurmeet R. Singh, Justine Clark (Adnyamathanha), Shalem Leemaqz, Ora Paltiel, David M. Roder, Benjamin Saxon, Ross McKinnon, Stephen J. Pandol, Claire T. Roberts, Savio George Barreto
Publikováno v:
Cancers, Vol 16, Iss 11, p 2057 (2024)
Background & Aims: Reports of a rise in childhood cancer incidence in Australia and globally prompted the investigation of cancer incidence and survival in South Australia (SA) and the Northern Territory (NT) over a 28-year period, with emphasis on I
Externí odkaz:
https://doaj.org/article/aad31f67f8e540a182ac7c399a1b2ba2