Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Stephen J, Morris"'
Autor:
Monica Bubenik, Pavel Mader, Philippe Mochirian, Fréderic Vallée, Jillian Clark, Jean-François Truchon, Alexander L. Perryman, Victor Pau, Igor Kurinov, Karl E. Zahn, Marie-Eve Leclaire, Robert Papp, Marie-Claude Mathieu, Martine Hamel, Nicole M. Duffy, Claude Godbout, Matias Casas-Selves, Jean-Pierre Falgueyret, Prasamit S. Baruah, Olivier Nicolas, Rino Stocco, Hugo Poirier, Giovanni Martino, Alexanne Bonneau Fortin, Anne Roulston, Amandine Chefson, Stéphane Dorich, Miguel St-Onge, Purvish Patel, Charles Pellerin, Stéphane Ciblat, Thomas Pinter, Francis Barabé, Majida El Bakkouri, Paranjay Parikh, Christian Gervais, Agnel Sfeir, Yael Mamane, Stephen J. Morris, W. Cameron Black, Frank Sicheri, Michel Gallant
Publikováno v:
Journal of Medicinal Chemistry. 65:13198-13215
Autor:
David Gallo, Jordan T. F. Young, Jimmy Fourtounis, Giovanni Martino, Alejandro Álvarez-Quilón, Cynthia Bernier, Nicole M. Duffy, Robert Papp, Anne Roulston, Rino Stocco, Janek Szychowski, Artur Veloso, Hunain Alam, Prasamit S. Baruah, Alexanne Bonneau Fortin, Julian Bowlan, Natasha Chaudhary, Jessica Desjardins, Evelyne Dietrich, Sara Fournier, Chloe Fugère-Desjardins, Theo Goullet de Rugy, Marie-Eve Leclaire, Bingcan Liu, Vivek Bhaskaran, Yael Mamane, Henrique Melo, Olivier Nicolas, Akul Singhania, Rachel K. Szilard, Ján Tkáč, Shou Yun Yin, Stephen J. Morris, Michael Zinda, C. Gary Marshall, Daniel Durocher
Publikováno v:
Nature. 604:749-756
Amplification of the CCNE1 locus on chromosome 19q12 is prevalent in multiple tumour types, particularly in high-grade serous ovarian cancer, uterine tumours and gastro-oesophageal cancers, where high cyclin E levels are associated with genome instab
Autor:
Monica, Bubenik, Pavel, Mader, Philippe, Mochirian, Fréderic, Vallée, Jillian, Clark, Jean-François, Truchon, Alexander L, Perryman, Victor, Pau, Igor, Kurinov, Karl E, Zahn, Marie-Eve, Leclaire, Robert, Papp, Marie-Claude, Mathieu, Martine, Hamel, Nicole M, Duffy, Claude, Godbout, Matias, Casas-Selves, Jean-Pierre, Falgueyret, Prasamit S, Baruah, Olivier, Nicolas, Rino, Stocco, Hugo, Poirier, Giovanni, Martino, Alexanne Bonneau, Fortin, Anne, Roulston, Amandine, Chefson, Stéphane, Dorich, Miguel, St-Onge, Purvish, Patel, Charles, Pellerin, Stéphane, Ciblat, Thomas, Pinter, Francis, Barabé, Majida, El Bakkouri, Paranjay, Parikh, Christian, Gervais, Agnel, Sfeir, Yael, Mamane, Stephen J, Morris, W Cameron, Black, Frank, Sicheri, Michel, Gallant
Publikováno v:
Journal of medicinal chemistry. 65(19)
DNA polymerase theta (Polθ) is an attractive synthetic lethal target for drug discovery, predicted to be efficacious against breast and ovarian cancers harboring BRCA-mutant alleles. Here, we describe our hit-to-lead efforts in search of a selective
Publikováno v:
BIOS. 88:135-143
Options for field anesthetics are somewhat limited for wild animals, particularly for small game mammals. We evaluated the efficacy of a reversible field anesthetic, “BAM” (butorphanol, azaperone, medetomidine; Wildlife Pharmaceuticals, Inc., Win
Publikováno v:
Spectroscopic Membrane Probes ISBN: 9781351076807
Spectroscopic Membrane Probes
Spectroscopic Membrane Probes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5d46efe697974005e3d52532728dda5
https://doi.org/10.1201/9781351076807-7
https://doi.org/10.1201/9781351076807-7
Autor:
Irit Itzhaki Van-Ham, Mireille Daigle, Liliane Robillard, Naghmeh Sajedi, Stephen J. Morris, Paul R. Albert
Publikováno v:
European Journal of Pharmacology. 577:44-53
Altered regulation of dopamine D(2) receptors is implicated in addiction, schizophrenia and movement disorders, as well as lactotroph growth and regulation. Dopamine D(2S) and dopamine D(2L) receptors are alternately-spliced variants that differ by 2
Autor:
Amir H. Salehi, Kathleen M. Dickson, Stephen J. Morris, Jon P. Durkin, Wai-Chi Ho, John W. Gillard, Snezana Milutinovic, Genevieve Doucet, Philip A. Barker
Publikováno v:
Chemistry & Biology. 13(2):213-223
SummaryWe describe a group of small-molecule inhibitors of Jun kinase (JNK)-dependent apoptosis. AEG3482, the parental compound, was identified in a screening effort designed to detect compounds that reduce apoptosis of neonatal sympathetic neurons a
Autor:
Gustavo Turecki, Christopher D. Bown, Xiao-Ming Ou, Pavel D. Hrdina, Adolfo Sequeira, Ajoy Basak, David Bakish, Lisheng Du, Neena Kushwaha, Stephen J. Morris, Paul R. Albert, Sylvie Lemonde
Publikováno v:
The Journal of Neuroscience. 23:8788-8799
Inhibition of serotonergic raphe neurons is mediated by somatodendritic 5-HT1A autoreceptors, which may be increased in depressed patients. We report an association of the C(-1019)G 5-HT1A promoter polymorphism with major depression and suicide in se
Autor:
Shannyn E. Wolfe, Stephen J. Morris
Publikováno v:
Journal of Neurochemistry. 73:2375-2382
The dopamine D2 receptor belongs to the serpentine superfamily of receptors, which have seven transmembrane segments and activate G proteins. D2 receptors are known to be linked, through Galpha(o)- and Galpha(i)-containing G proteins, to several sign
Autor:
Tracy D. Davis, Malcolm J. Low, Stephen J. Morris, S. J. Enna, Shannyn E. Wolfe, Diane M. Beatty, Bibie M. Chronwall, Mathew W. Severidt, Kenneth E. McCarson
Publikováno v:
Journal of Neurochemistry. 77:1237-1247
Studies of gamma-aminobutyric acid (GABA)(B) receptor function in heterologous cell systems have suggested that expression of two distinct seven transmembrane G-protein coupled receptor subunits is necessary for receptor activation and signal transdu