Zobrazeno 1 - 10
of 394
pro vyhledávání: '"Stephen J, Meltzer"'
Autor:
Sarah Laun, Francia Pierre, Suji Kim, Daniel Lunz, Tara Maddala, Jerome V. Braun, Stephen J. Meltzer, Lisa Kann
Publikováno v:
Diagnostics, Vol 14, Iss 18, p 2003 (2024)
EsopredictTM is a prognostic assay that risk-stratifies Barrett’s esophagus patients to predict future progression to high-grade dysplasia (HGD) or esophageal adenocarcinoma (EAC). Established based on foundational studies at Johns Hopkins Universi
Externí odkaz:
https://doaj.org/article/9c432a78a91f4fd6acab1efd58f9922e
Autor:
Yuan Jiang, Hua Zhao, Shuai Kong, Dan Zhou, Jinxiu Dong, Yulan Cheng, Shuo Zhang, Fei Wang, Andrew Kalra, Nina Yang, Dan-Dan Wei, Jian Chen, Yuan-Wei Zhang, De-Chen Lin, Stephen J. Meltzer, Yan-Yi Jiang
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 1 (2024)
Externí odkaz:
https://doaj.org/article/e53e842f3d464acb9618de35373ff6c9
Autor:
Yin Peng, Yidan Xu, Xiaojing Zhang, Shiqi Deng, Yuan Yuan, Xiaonuan Luo, Md Tofazzal Hossain, Xiaohui Zhu, Kaining Du, Fan Hu, Yang Chen, Shanshan Chang, Xianling Feng, Xinmin Fan, Hassan Ashktorab, Duane Smoot, Stephen J. Meltzer, Gangqiang Hou, Yanjie Wei, Song Li, Ying Qin, Zhe Jin
Publikováno v:
Molecular Cancer, Vol 20, Iss 1, Pp 1-19 (2021)
Abstract Background Circular RNA (circRNA), a subclass of non-coding RNA, plays a critical role in cancer tumorigenesis and metastasis. It has been suggested that circRNA acts as a microRNA sponge or a scaffold to interact with protein complexes; how
Externí odkaz:
https://doaj.org/article/8c037b1b95034b6294d7f4a5465b9ed9
Autor:
Xiaonuan Luo, Shanshan Chang, Siyu Xiao, Yin Peng, Yuli Gao, Fan Hu, Jianxue Liang, Yidan Xu, Kaining Du, Yang Chen, Jiequan Qin, Stephen J. Meltzer, Shiqi Deng, Xianling Feng, Xinmin Fan, Gangqiang Hou, Zhe Jin, Xiaojing Zhang
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 33, Iss , Pp 100835- (2022)
Peptidylarginine deiminase 4 (PAD4), a Ca2+-dependent enzyme, catalyzes the conversion of arginine to citrulline and has been strongly associated with many malignant tumors. However, the molecular mechanisms of PAD4 in the development and progression
Externí odkaz:
https://doaj.org/article/9499824cb909457b9d94db2f4471b108
Autor:
Li-Yan Li, Qian Yang, Yan-Yi Jiang, Wei Yang, Yuan Jiang, Xiang Li, Masaharu Hazawa, Bo Zhou, Guo-Wei Huang, Xiu-E Xu, Sigal Gery, Ying Zhang, Ling-Wen Ding, Allen S. Ho, Zachary S. Zumsteg, Ming-Rong Wang, Melissa J. Fullwood, Stephen J. Freedland, Stephen J. Meltzer, Li-Yan Xu, En-Min Li, H. Phillip Koeffler, De-Chen Lin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The relevance and underlying molecular mechanisms of epigenetic regulation in squamous cell carcinomas (SCC) await further characterization. Here, the authors show a transcriptional regulatory loop involving SREBF1, TP63 and KLF5 driving tumourigenes
Externí odkaz:
https://doaj.org/article/bb5f76c06e2f4727bd8409644acda48f
Autor:
Christopher K. Ng, Ke Ma, Yulan Cheng, Tomoharu Miyashita, John W. Harmon, Stephen J. Meltzer
Publikováno v:
Translational Oncology, Vol 12, Iss 11, Pp 1432-1441 (2019)
Krüppel-like Factor 5 (KLF5) is a zinc-finger transcription factor associated with cell cycle progression and cell survival. KLF5 plays a key role in mammalian intestinal epithelium development and maintenance, expressed at high levels in basal prol
Externí odkaz:
https://doaj.org/article/70569b9d47664509b60062faf2b2bd81
Autor:
Ling Li, Gilad Halpert, Michael G. Lerner, Haijie Hu, Peter Dimitrion, Matthew J. Weiss, Jin He, Benjamin Philosophe, Richard Burkhart, William R. Burns, Russell N. Wesson, Andrew MacGregor Cameron, Christopher L. Wolfgang, Christos Georgiades, Satomi Kawamoto, Nilofer S. Azad, Mark Yarchoan, Stephen J. Meltzer, Kiyoko Oshima, Laura M. Ensign, Joel S. Bader, Florin M. Selaru
Publikováno v:
JCI Insight, Vol 6, Iss 12 (2021)
Hepatocellular carcinoma (HCC) is the sixth most common and the fourth most deadly cancer worldwide. The development cost of new therapeutics is a major limitation in patient outcomes. Importantly, there is a paucity of preclinical HCC models in whic
Externí odkaz:
https://doaj.org/article/f683fedaae0d4fbb8bdd07f74ee54fb0
Synthetic Circular RNA Functions as a miR-21 Sponge to Suppress Gastric Carcinoma Cell Proliferation
Autor:
Xi Liu, John M. Abraham, Yulan Cheng, Zhixiong Wang, Zhe Wang, Guanjun Zhang, Hassan Ashktorab, Duane T. Smoot, Robert N. Cole, Tatiana N. Boronina, Lauren R. DeVine, C. Conover Talbot, Jr., Zhengwen Liu, Stephen J. Meltzer
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 13, Iss , Pp 312-321 (2018)
MicroRNA (miR) sponges containing miR binding sequences constitute a potentially powerful molecular therapeutic strategy. Recently, naturally occurring circular RNAs (circRNAs) were shown to function as efficient miR sponges in cancer cells. We hypot
Externí odkaz:
https://doaj.org/article/6d47a7e65b7f47b8a66999a33eaf703f
Autor:
Yin Peng, Ying Qin, Xiaojing Zhang, Shiqi Deng, Yuan Yuan, Xianling Feng, Wangchun Chen, Fan Hu, Yuli Gao, Jieqiong He, Yulan Cheng, Yanjie Wei, Xinmin Fan, Hassan Ashktorab, Duane Smoot, Song Li, Stephen J. Meltzer, Shutong Zhuang, Na Tang, Zhe Jin
Publikováno v:
Heliyon, Vol 7, Iss 4, Pp e06695- (2021)
Previous research has found that miRNA-20b is highly expressed in gastric cancer (GC), however, its function and underlying mechanism are not clear. Wnt signaling pathway, implicated in tumorigeneisis, is activated in more than 30% of GC. We would li
Externí odkaz:
https://doaj.org/article/906712af377c47be9f61ba21940cf2f7
Autor:
Xiquan Ke, Rong Yan, Zhenguo Sun, Yulan Cheng, Amy Meltzer, Nonghua Lu, Xu Shu, Zhe Wang, Binbin Huang, Xi Liu, Zhixiong Wang, Jee Hoon Song, Christopher K Ng, Sariat Ibrahim, John M. Abraham, Eun Ji Shin, Shuixiang He, Stephen J. Meltzer
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 19, Iss 11, Pp 941-949 (2017)
There have been no reports describing the effects of cancer cell–derived extracellular vesicles (EVs) on three-dimensional organoids. In this study, we delineated the proneoplastic effects of esophageal adenocarcinoma (EAC)–derived EVs on gastric
Externí odkaz:
https://doaj.org/article/6351957d40d5485882571b902cee7c20