Zobrazeno 1 - 10
of 258
pro vyhledávání: '"Stephen J, McSorley"'
Autor:
Jordan A Rixon, Kevin D Fong, Claire Morris, Alana T Nguyen, Claire E Depew, Stephen J McSorley
Publikováno v:
PLoS Pathogens, Vol 20, Iss 1, p e1011914 (2024)
Chlamydia vaccine approaches aspire to induce Th1 cells for optimal protection, despite the fact that there is no direct evidence demonstrating Th1-mediated Chlamydia clearance from the female reproductive tract (FRT). We recently reported that T-bet
Externí odkaz:
https://doaj.org/article/d7f6c3d59cc04578bb2272178b7cf035
Autor:
Yashavanth Shaan Lakshmanappa, Sonny R. Elizaldi, Jamin W. Roh, Brian A. Schmidt, Timothy D. Carroll, Kourtney D. Weaver, Justin C. Smith, Anil Verma, Jesse D. Deere, Joseph Dutra, Mars Stone, Sergej Franz, Rebecca Lee Sammak, Katherine J. Olstad, J. Rachel Reader, Zhong-Min Ma, Nancy K. Nguyen, Jennifer Watanabe, Jodie Usachenko, Ramya Immareddy, JoAnn L. Yee, Daniela Weiskopf, Alessandro Sette, Dennis Hartigan-O’Connor, Stephen J. McSorley, John H. Morrison, Nam K. Tran, Graham Simmons, Michael P. Busch, Pamela A. Kozlowski, Koen K. A. Van Rompay, Christopher J. Miller, Smita S. Iyer
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Induction of CD4 T follicular helper (Tfh) cells is important for antibody responses to viral infections. Here, the authors show in a rhesus macaque model of mild COVID-19 that SARS-CoV-2 infection results in transient accumulation of proliferating T
Externí odkaz:
https://doaj.org/article/0b3b94e948d5442aa6b0f00f729b8c20
Publikováno v:
PLoS Pathogens, Vol 18, Iss 2, p e1010333 (2022)
Protective immune responses to Chlamydia infection within the female reproductive tract (FRT) are incompletely understood. MHC class II-restricted CD4 Th1 responses are believed to be vital for bacterial clearance due to their capacity to secrete IFN
Externí odkaz:
https://doaj.org/article/af871a870ead42d1876e36416cc19b3f
Autor:
Newton G. Peres, Nancy Wang, Paul Whitney, Sven Engel, Meghanashree M. Shreenivas, Ian Comerford, Dianna M. Hocking, Anna B. Erazo, Irmgard Förster, Andreas Kupz, Thomas Gebhardt, Shaun R. McColl, Stephen J. McSorley, Sammy Bedoui, Richard A. Strugnell
Publikováno v:
PLoS Pathogens, Vol 17, Iss 10 (2021)
While Salmonella enterica is seen as an archetypal facultative intracellular bacterial pathogen where protection is mediated by CD4+ T cells, identifying circulating protective cells has proved very difficult, inhibiting steps to identify key antigen
Externí odkaz:
https://doaj.org/article/2cba44dd59ea4403844f41d34e30910e
Autor:
Emma C. Skoog, Miriam E. Martin, Roberto M. Barrozo, Lori M. Hansen, Lucy P. Cai, Seung-Joo Lee, Joseph M. Benoun, Stephen J. McSorley, Jay V. Solnick
Publikováno v:
mBio, Vol 11, Iss 6 (2020)
ABSTRACT The Helicobacter pylori type IV secretion system (T4SS) encoded on the cag pathogenicity island (cagPAI) secretes the CagA oncoprotein and other effectors into the gastric epithelium. During murine infection, T4SS function is lost in an immu
Externí odkaz:
https://doaj.org/article/ea71d867c36a445497d0f3395c5cbdea
Autor:
Oanh H. Pham, Bokyung Lee, Jasmine Labuda, A. Marijke Keestra-Gounder, Mariana X. Byndloss, Renée M. Tsolis, Stephen J. McSorley
Publikováno v:
mBio, Vol 11, Iss 3 (2020)
ABSTRACT The inflammatory response to Chlamydia infection is likely to be multifactorial and involve a variety of ligand-dependent and -independent recognition pathways. We previously reported the presence of NOD1/NOD2-dependent endoplasmic reticulum
Externí odkaz:
https://doaj.org/article/3acb15e5e9f04ec2a6f2b6c47dfd3fcb
Autor:
Jin Wook Choi, Sita S Withers, Hong Chang, Justin A Spanier, Victoria L De La Trinidad, Harmanpreet Panesar, Brian T Fife, Roger Sciammas, Ellen E Sparger, Peter F Moore, Michael S Kent, Robert B Rebhun, Stephen J McSorley
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0235518 (2020)
Interruption of the programmed death 1 (PD-1) / programmed death ligand 1 (PD-L1) pathway is an established and effective therapeutic strategy in human oncology and holds promise for veterinary oncology. We report the generation and characterization
Externí odkaz:
https://doaj.org/article/f05654296edd40d39bd096f9fc678bd8
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 120, iss 16
Hepatic CD4 tissue-resident memory T cells (TRM) are required for robust protection against Salmonella infection; however, the generation of this T cell population is poorly understood. To interrogate the contribution of inflammation, we developed a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8478fdde820fc4faf8c21dd6a76066d4
https://doi.org/10.1073/pnas.2214699120
https://doi.org/10.1073/pnas.2214699120
Publikováno v:
Immunohorizons
ImmunoHorizons, vol 6, iss 2
ImmunoHorizons, vol 6, iss 2
The presence of memory lymphocytes in nonlymphoid tissues reflects prior immunological experience and can provide nonspecific defense against infection. In this study, we used a mouse cohousing approach to examine the effect of prior immunological ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee0ac6c28fc61fea21b75b5d9781ae66
https://doi.org/10.4049/immunohorizons.2100069
https://doi.org/10.4049/immunohorizons.2100069
Autor:
Oanh H Pham, Hope O'Donnell, Aymen Al-Shamkhani, Tobias Kerrinnes, Renée M Tsolis, Stephen J McSorley
Publikováno v:
PLoS Pathogens, Vol 13, Iss 8, p e1006566 (2017)
Th1 cells can be activated by TCR-independent stimuli, but the importance of this pathway in vivo and the precise mechanisms involved require further investigation. Here, we used a simple model of non-cognate Th1 cell stimulation in Salmonella-infect
Externí odkaz:
https://doaj.org/article/ca5781e68f3c489fba9362ee667589ec