Zobrazeno 1 - 10
of 1 153
pro vyhledávání: '"Stephen J, Lippard"'
Autor:
Yi Wen Kong, Erik C. Dreaden, Sandra Morandell, Wen Zhou, Sanjeev S. Dhara, Ganapathy Sriram, Fred C. Lam, Jesse C. Patterson, Mohiuddin Quadir, Anh Dinh, Kevin E. Shopsowitz, Shohreh Varmeh, Ömer H. Yilmaz, Stephen J. Lippard, H. Christian Reinhardt, Michael T. Hemann, Paula T. Hammond, Michael B. Yaffe
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Cell cycle checkpoint kinase, MK2, is in synthetic relationship with p53 in the DNA damage response to chemotherapeutic agents. Here, the authors report XPA as a third gene in which simultaneous targeting of MK2 and XPA further enhances sensitivity t
Externí odkaz:
https://doaj.org/article/968af14e7f93410d8098ad17f0bc993d
Autor:
Ali Barandov, Benjamin B. Bartelle, Catherine G. Williamson, Emily S. Loucks, Stephen J. Lippard, Alan Jasanoff
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
There are only few MRI-compatible calcium reporters and they are limited to measuring extracellular calcium levels. Here the authors develop and validate a cell-permeable, manganese-based paramagnetic MRI contrast agent that enables monitoring intrac
Externí odkaz:
https://doaj.org/article/e5faf82e358e48b88a58d6f635d5f18c
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Abstract Small-molecule fluorescent probes are powerful and ubiquitous tools for measuring the concentration and distribution of analytes in living cells. However, accurate characterization of these analytes requires rigorous evaluation of cell-to-ce
Externí odkaz:
https://doaj.org/article/852635636b5e4591bccbb61e1037cb31
Autor:
Stephen J. Lippard, Eric Raymond, Sandrine Faivre, Esteban Cvitkovic, Christian Gespach, Eugenio Erba, Massimo Broggini, Maurizio D'Incalci, Shahin Emami, Ivan Bieche, Maria Serova, Katherine S. Lovejoy
Pyriplatin, cis-diammine(pyridine)chloroplatinum(II), a platinum-based antitumor drug candidate, is a cationic compound with anticancer properties in mice and is a substrate for organic cation transporters that facilitate oxaliplatin uptake. Unlike c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40a7ec47b3e1bba4fab6a6c0775215cb
https://doi.org/10.1158/1535-7163.c.6535264
https://doi.org/10.1158/1535-7163.c.6535264
Autor:
Zdravka Medarova, Stephen J. Lippard, Anna Moore, Seok-Hyun Yun, Xiao-an Zhang, Pilhan Kim, Subrata K. Ghosh
Supplementary Movie 2 from A Novel Imaging Approach for Early Detection of Prostate Cancer Based on Endogenous Zinc Sensing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f946414cc9fe8ef91668f83a85bf28d
https://doi.org/10.1158/0008-5472.22381925
https://doi.org/10.1158/0008-5472.22381925
Autor:
Kathleen M. Giacomini, Stephen J. Lippard, Xin Chen, Joe W. Gray, Takafumi Komori, Ying Chen, Anna Lapuk, Yan Shu, Leah L. Lagpacan, James E. Shima, Katherine S. Lovejoy, Shuzhong Zhang
Although the platinum-based anticancer drugs cisplatin, carboplatin, and oxaliplatin have similar DNA-binding properties, only oxaliplatin is active against colorectal tumors. The mechanisms for this tumor specificity of platinum-based compounds are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc12a447e6712d143b4af76723b2a50d
https://doi.org/10.1158/0008-5472.c.6494126
https://doi.org/10.1158/0008-5472.c.6494126
Autor:
Zdravka Medarova, Stephen J. Lippard, Anna Moore, Seok-Hyun Yun, Xiao-an Zhang, Pilhan Kim, Subrata K. Ghosh
The early detection of prostate cancer is a life-saving event in patients harboring potentially aggressive disease. With the development of malignancy, there is a dramatic reduction in the zinc content of prostate tissue associated with the inability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5b955470c3fc58a79cbedf15b9e5c74
https://doi.org/10.1158/0008-5472.c.6500033.v1
https://doi.org/10.1158/0008-5472.c.6500033.v1
Autor:
Zdravka Medarova, Stephen J. Lippard, Anna Moore, Seok-Hyun Yun, Xiao-an Zhang, Pilhan Kim, Subrata K. Ghosh
Supplementary Materials, Figure Legends 1-3, Movie Legends 1-4 from A Novel Imaging Approach for Early Detection of Prostate Cancer Based on Endogenous Zinc Sensing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12c93d09f33196be311c4ca29eea686d
https://doi.org/10.1158/0008-5472.22381931.v1
https://doi.org/10.1158/0008-5472.22381931.v1
Autor:
Kathleen M. Giacomini, Stephen J. Lippard, Xin Chen, Joe W. Gray, Takafumi Komori, Ying Chen, Anna Lapuk, Yan Shu, Leah L. Lagpacan, James E. Shima, Katherine S. Lovejoy, Shuzhong Zhang
Supplementary Table 1 from Organic Cation Transporters Are Determinants of Oxaliplatin Cytotoxicity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05465810f312ba00278db2bf1329f602
https://doi.org/10.1158/0008-5472.22364303
https://doi.org/10.1158/0008-5472.22364303
PDF - 1937K, Supplementary Materials and Methods. Supplementary Figure 1: Sequences of the 21-mer/33-mer duplexes containing site-specific platinum lesions for the construction of 146-bp duplexes. Supplementary Figure 2: Autoradiograph of a small DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57e60ead8f0c202b159ef5c4c8d64351
https://doi.org/10.1158/0008-5472.22398227.v1
https://doi.org/10.1158/0008-5472.22398227.v1