Zobrazeno 1 - 10
of 484
pro vyhledávání: '"Stephen J, Lewis"'
Autor:
James N. Bates, Santhosh M. Baby, Paulina M. Getsy, Gregory A. Coffee, Yee-Hsee Hsieh, Zackery T. Knauss, Albert Dahan, Jason A. Bubier, Peter M. MacFarlane, Devin Mueller, Stephen J. Lewis
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract N-acetyl-L-cysteine (L-NAC) is a proposed therapeutic for opioid use disorder. This study determined whether co-injections of L-NAC (500 μmol/kg, IV) or its highly cell-penetrant analogue, L-NAC methyl ester (L-NACme, 500 μmol/kg, IV), pre
Externí odkaz:
https://doaj.org/article/7cf134f1aa4b40f786d4d28221785b6e
Autor:
Luca Ambrosio, Gianluca Vadalà, Javad Tavakoli, Laura Scaramuzzo, Giovanni Barbanti Brodano, Stephen J. Lewis, So Kato, Samuel K. Cho, S. Tim Yoon, Ho-Joong Kim, Matthew F. Gary, Vincenzo Denaro
Publikováno v:
Neurospine, Vol 21, Iss 1, Pp 204-211 (2024)
Objective To evaluate the global practice pattern of wound dressing use after lumbar fusion for degenerative conditions. Methods A survey issued by AO Spine Knowledge Forums Deformity and Degenerative was sent out to AO Spine members. The type of pos
Externí odkaz:
https://doaj.org/article/d8dd989c6f7d46bf9a42ef609ef2bf96
Autor:
Jennifer McDonough, Naveen K. Singhal, Paulina M. Getsy, Katherine Knies, Zackery T. Knauss, Devin Mueller, James N. Bates, Derek S. Damron, Stephen J. Lewis
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
We have reported that D,L-thiol esters, including D-cysteine ethyl ester (D-CYSee), are effective at overcoming opioid-induced respiratory depression (OIRD) in rats. Our on-going studies reveal that co-injections of D-CYSee with multi-day morphine in
Externí odkaz:
https://doaj.org/article/b770ebd95e5f4062957719f54007718e
Autor:
Paulina M. Getsy, Gregory A. Coffee, James N. Bates, Theodore Parran, Lee Hoffer, Santhosh M. Baby, Peter M. MacFarlane, Zackery T. Knauss, Derek S. Damron, Yee-Hsee Hsieh, Jason A. Bubier, Devin Mueller, Stephen J. Lewis
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
The ability of morphine to decrease cysteine transport into neurons by inhibition of excitatory amino acid transporter 3 (EAA3) may be a key molecular mechanism underlying the acquisition of physical and psychological dependence to morphine. This stu
Externí odkaz:
https://doaj.org/article/25505fc3abd147f1bfb54bb923d7270b
Autor:
Paulina M. Getsy, Walter J. May, Alex P. Young, Santhosh M. Baby, Gregory A. Coffee, James N. Bates, Yee-Hsee Hsieh, Stephen J. Lewis
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Our lab is investigating the efficacy profiles of tropine analogs against opioid-induced respiratory depression. The companion manuscript reports that the cell-permeant tropeine, tropine ester (Ibutropin), produces a rapid and sustained reversal of t
Externí odkaz:
https://doaj.org/article/206aecfd4bd54baca01b5da85e16ff77
Autor:
Santhosh M. Baby, Walter J. May, Paulina M. Getsy, Gregory A. Coffee, Tej Nakashe, James N. Bates, Alan Levine, Stephen J. Lewis
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Fentanyl elicits profound disturbances in ventilatory control processes in humans and experimental animals. The traditional viewpoint with respect to fentanyl-induced respiratory depression is that once the effects on the frequency of breathing (Freq
Externí odkaz:
https://doaj.org/article/18e3f66e88b64ca59062ba0937b3b4e6
Autor:
James N. Bates, Paulina M. Getsy, Gregory A. Coffee, Santhosh M. Baby, Peter M. MacFarlane, Yee-Hsee Hsieh, Zackery T. Knauss, Jason A. Bubier, Devin Mueller, Stephen J. Lewis
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2024)
We examined whether co-injections of the cell-permeant D-cysteine analogues, D-cysteine ethyl ester (D-CYSee) and D-cysteine ethyl amide (D-CYSea), prevent acquisition of physical dependence induced by twice-daily injections of fentanyl, and reverse
Externí odkaz:
https://doaj.org/article/5ab96a619e0f445aae20d91926abf672
Autor:
Y. Raja Rampersaud, Kala Sundararajan, Shgufta Docter, Anthony V. Perruccio, Rajiv Gandhi, Diana Adams, Natasha Briggs, J. Rod Davey, Michael Fehlings, Stephen J. Lewis, Rosalie Magtoto, Eric Massicotte, Angela Sarro, Khalid Syed, Nizar N. Mahomed, Christian Veillette
Publikováno v:
BMC Health Services Research, Vol 23, Iss 1, Pp 1-15 (2023)
Abstract Background The incremental hospital cost and length of stay (LOS) associated with adverse events (AEs) has not been well characterized for planned and unplanned inpatient spine, hip, and knee surgeries. Methods Retrospective cohort study of
Externí odkaz:
https://doaj.org/article/e542eae0dccb456d8832c03f2640d75d
Publikováno v:
Frontiers in Physiology, Vol 14 (2024)
Histone deacetylase 6 (HDAC6) is a class II histone deacetylase that is predominantly localized in the cytoplasm of cells. HDAC6 associates with microtubules and regulates acetylation of tubulin and other proteins. The possibility that HDAC6 particip
Externí odkaz:
https://doaj.org/article/1a0ad43d74604fba86c7706aa02b3a31
Autor:
Santhosh M. Baby, Walter J. May, Alex P. Young, Christopher G. Wilson, Paulina M. Getsy, Gregory A. Coffee, Tristan H.J. Lewis, Yee-Hee Hsieh, James N. Bates, Stephen J. Lewis
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 171, Iss , Pp 116081- (2024)
L-cysteine ethylester (L-CYSee) is a membrane-permeable analogue of L-cysteine with a variety of pharmacological effects. The purpose of this study was to determine the effects of L-CYSee on morphine-induced changes in ventilation, arterial-blood gas
Externí odkaz:
https://doaj.org/article/700e8d74e6a44a1294fa6ee737f3d673