Zobrazeno 1 - 10
of 238
pro vyhledávání: '"Stephen J, Kron"'
Autor:
Weihan Liu, Jeffrey L. Kurkewich, Angela Stoddart, Saira Khan, Dhivyaa Anandan, Alexandre N. Gaubil, Donald J. Wolfgeher, Lia Jueng, Stephen J. Kron, Megan E. McNerney
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114227- (2024)
Summary: CUX1 is a homeodomain-containing transcription factor that is essential for the development and differentiation of multiple tissues. CUX1 is recurrently mutated or deleted in cancer, particularly in myeloid malignancies. However, the mechani
Externí odkaz:
https://doaj.org/article/9e644aaf832c44c3980cb9a37d45679f
Publikováno v:
Cells, Vol 13, Iss 15, p 1281 (2024)
Cellular senescence has been increasingly recognized as a hallmark of cancer, reflecting its association with aging and inflammation, its role as a response to deregulated proliferation and oncogenic stress, and its induction by cancer therapies. Whi
Externí odkaz:
https://doaj.org/article/06ccceb37f73490cb5ad60b3085a700a
Autor:
Yue Liu, Stephen J. Kron
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102677- (2023)
Summary: Therapy-induced senescence (TIS) may contribute to therapy resistance; however, evidence also suggests that senescent cells (SnCs) may promote anti-tumor immunity. Here, we present a protocol for examining the capability of TIS to stimulate
Externí odkaz:
https://doaj.org/article/d6ba489e1b794b32a907982a63a8b417
Autor:
Manisha Krishnan, Madhavi D. Senagolage, Jeremy T. Baeten, Donald J. Wolfgeher, Saira Khan, Stephen J. Kron, Megan E. McNerney
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract CUX1, encoding a homeodomain-containing transcription factor, is recurrently deleted or mutated in multiple tumor types. In myeloid neoplasms, CUX1 deletion or mutation carries a poor prognosis. We have previously established that CUX1 funct
Externí odkaz:
https://doaj.org/article/e22a817114af4516b40e2afc16f9f015
Autor:
Yue Liu, Joanna Pagacz, Donald J Wolfgeher, Kenneth D Bromerg, Jacob V Gorman, Stephen J Kron
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 2 (2023)
Background Immune tolerance contributes to resistance to conventional cancer therapies such as radiation. Radiotherapy induces immunogenic cell death, releasing a burst of tumor antigens, but this appears insufficient to stimulate an effective antitu
Externí odkaz:
https://doaj.org/article/850cfcfd9d5b4e68a8f837ab9763b19e
Autor:
Bàrbara Samper-Martín, Ana Sarrias, Blanca Lázaro, Marta Pérez-Montero, Rosalía Rodríguez-Rodríguez, Mariana P.C. Ribeiro, Aitor Bañón, Don Wolfgeher, Henning J. Jessen, Berta Alsina, Josep Clotet, Stephen J. Kron, Adolfo Saiardi, Javier Jiménez, Samuel Bru
Publikováno v:
Cell Reports, Vol 37, Iss 7, Pp 110004- (2021)
Summary: Polyphosphate (polyP) is a polymer of hundreds of phosphate residues present in all organisms. In mammals, polyP is involved in crucial physiological processes, including coagulation, inflammation, and stress response. However, after decades
Externí odkaz:
https://doaj.org/article/90c4e621b4e446d2a23899e2baa3a8aa
Autor:
Joanna Jeleńska, Jiyoung Lee, Andrew J. Manning, Donald J. Wolfgeher, Youngjoo Ahn, George Walters-Marrah, Ivan E. Lopez, Lissette Garcia, Sheri A. McClerklin, Richard W. Michelmore, Stephen J. Kron, Jean T. Greenberg
Publikováno v:
PLoS Pathogens, Vol 17, Iss 11 (2021)
The plant pathogen Pseudomonas syringae secretes multiple effectors that modulate plant defenses. Some effectors trigger defenses due to specific recognition by plant immune complexes, whereas others can suppress the resulting immune responses. The H
Externí odkaz:
https://doaj.org/article/8e60f569af984f688b61cb246ca9c90b
Autor:
Natalia Ricco, Amy Flor, Don Wolfgeher, Elena V. Efimova, Aishwarya Ramamurthy, Oliver K. Appelbe, Jacqueline Brinkman, Andrew W. Truman, Michael T. Spiotto, Stephen J. Kron
Publikováno v:
Molecular Oncology, Vol 13, Iss 9, Pp 1927-1943 (2019)
Radioresistance is a major hurdle in the treatment of head and neck squamous cell carcinoma (HNSCC). Here, we report that concomitant treatment of HNSCCs with radiotherapy and mevalonate pathway inhibitors (statins) may overcome resistance. Proteomic
Externí odkaz:
https://doaj.org/article/c9b43aab1c114bd4b7546f87f2756ce4
Autor:
Sara Hernández-Ortega, Abril Sánchez-Botet, Eva Quandt, Núria Masip, Laura Gasa, Gaetano Verde, Javier Jiménez, Rebecca S. Levin, Florentine U. Rutaganira, Alma L. Burlingame, Don Wolfgeher, Mariana P. C. Ribeiro, Stephen J. Kron, Kevan M. Shokat, Josep Clotet
Publikováno v:
Experimental and Molecular Medicine, Vol 51, Iss 4, Pp 1-17 (2019)
Cancer: Proteins that work together could reveal drug targets Studying the activity of proteins that work together to control cell division is revealing several that might be suitable targets for new drugs to fight cancer. Researchers led by Josep Cl
Externí odkaz:
https://doaj.org/article/1dcd687f68334e9fa27d9b82540c2994
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-12 (2019)
Abstract Background Diverse stresses including genotoxic therapy can induce proliferating cancer cells to undergo cellular senescence and take on the characteristic phenotypes of replicative cellular aging. This accelerated or therapy-induced senesce
Externí odkaz:
https://doaj.org/article/abc5cb6b49da43c2943bd053ecb3c93e