Zobrazeno 1 - 10
of 211
pro vyhledávání: '"Stephen J, Kennel"'
Autor:
Stephen J Kennel, Joseph W Jackson, Alan Stuckey, Tina Richey, James S Foster, Jonathan S Wall
Publikováno v:
PLoS ONE, Vol 19, Iss 4, p e0301756 (2024)
IntroductionAmyloid deposition is a cause of restrictive cardiomyopathy. Patients who present with cardiac disease can be evaluated for transthyretin (TTR)-associated cardiac amyloidosis using nuclear imaging with 99mTc-labeled pyrophosphate (PYP); h
Externí odkaz:
https://doaj.org/article/ae00333921e540a68f07fb68eada90da
Autor:
James S. Foster, Manasi Balachandran, Trevor J. Hancock, Emily B. Martin, Sallie Macy, Craig Wooliver, Tina Richey, Alan Stuckey, Angela D. Williams, Joseph W. Jackson, Stephen J. Kennel, Jonathan S. Wall
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionSystemic amyloidosis is a progressive disorder characterized by the extracellular deposition of amyloid fibrils and accessory proteins in visceral organs and tissues. Amyloid accumulation causes organ dysfunction and is not generally clea
Externí odkaz:
https://doaj.org/article/3ce636148a204e3aafd0f0efaec0fd54
Autor:
Emily B. Martin, Alan Stuckey, Dustin Powell, Ronald Lands, Bryan Whittle, Craig Wooliver, Sallie Macy, James S. Foster, Spencer Guthrie, Stephen J. Kennel, Jonathan S. Wall
Publikováno v:
Pharmaceuticals, Vol 16, Iss 4, p 629 (2023)
There are at least 20 distinct types of systemic amyloidosis, all of which result in the organ-compromising accumulation of extracellular amyloid deposits. Amyloidosis is challenging to diagnose due to the heterogeneity of the clinical presentation,
Externí odkaz:
https://doaj.org/article/0c7a66e5b85e4db4a58eeeaf99099fad
Autor:
Joseph W. Jackson, James S. Foster, Emily B. Martin, Sallie Macy, Craig Wooliver, Manasi Balachandran, Tina Richey, R. Eric Heidel, Angela D. Williams, Stephen J. Kennel, Jonathan S. Wall
Publikováno v:
Amyloid. :1-12
Autor:
Emily B. Martin, Angela Williams, Tina Richey, Craig Wooliver, Alan Stuckey, James S. Foster, Stephen J. Kennel, Jonathan S. Wall
Publikováno v:
Journal of Translational Medicine, Vol 15, Iss 1, Pp 1-11 (2017)
Abstract Background Systemic amyloidoses comprise diseases characterized by the deposition of proteinaceous material known as amyloid. Currently, without performing multiple biopsies, there is no way to ascertain the extent of amyloid deposition in p
Externí odkaz:
https://doaj.org/article/557423129c224980958d264ad5096d06
Autor:
Dennis W. Piehl, Luis M. Blancas-Mejía, Jonathan S. Wall, Stephen J. Kennel, Marina Ramirez-Alvarado, Chad M. Rienstra
Publikováno v:
ACS Omega, Vol 2, Iss 2, Pp 712-720 (2017)
Externí odkaz:
https://doaj.org/article/b72ab429b8c844548d24d58e86e070cf
Autor:
Joseph W. Jackson, Trevor J. Hancock, Pranay Dogra, Ravi Patel, Ravit Arav-Boger, Angela D. Williams, Stephen J. Kennel, Jonathan S. Wall, Tim E. Sparer
Publikováno v:
mSphere, Vol 4, Iss 1 (2019)
ABSTRACT Human cytomegalovirus (HCMV) is a ubiquitous betaherpesvirus that can cause severe disease following in utero exposure, during primary infection, or latent virus reactivation in immunocompromised populations. These complications lead to a 1-
Externí odkaz:
https://doaj.org/article/bfe1c8b9badd479a977a7cc7b9f954e9
Autor:
Ronald H. Lands, Michael G. Stabin, Dustin Powell, Bryan Whittle, Aaron Endsley, Alan Stuckey, Ryan R. Julian, Tyler R. Lambeth, Emily B. Martin, Stephen J. Kennel, Angela Williams, Jonathan S. Wall, Sarah Hall
Publikováno v:
Molecular Imaging and Biology. 24:479-488
Purpose Accurate diagnosis of amyloidosis remains a significant clinical challenge and unmet need for patients. The amyloid-reactive peptide p5+14 radiolabeled with iodine-124 has been developed for the detection of amyloid by PET/CT imaging. In a fi
Autor:
Jonathan S. Wall, Emily B. Martin, Tina Richey, Alan C. Stuckey, Sallie Macy, Craig Wooliver, Angela Williams, James S. Foster, Penney McWilliams-Koeppen, Ed Uberbacher, Xiaolin Cheng, Stephen J. Kennel
Publikováno v:
Molecules, Vol 20, Iss 5, Pp 7657-7682 (2015)
Amyloid is a complex pathologic matrix comprised principally of paracrystalline protein fibrils and heparan sulfate proteoglycans. Systemic amyloid diseases are rare, thus, routine diagnosis is often challenging. The glycosaminoglycans ubiquitously p
Externí odkaz:
https://doaj.org/article/599fcb02977e46dc8ccd340512015f8d
Autor:
Emily B. Martin, Alan Stuckey, Tina Richey, Robert L. Donnell, Stephen J. Kennel, Jonathan S. Wall
Publikováno v:
Biochem Biophys Res Commun
Peptide p5R is a synthetic, polybasic, heparin-binding peptide that preferentially reacts with amyloid deposits in vivo and in tissue sections. Basic fibroblast growth factor (bFGF1) similarly interacts with heparin-like molecules, notably heparan su