Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Stephen J, Headey"'
Autor:
Mahta Mansouri, Shawn Rumrill, Shane Dawson, Adam Johnson, Jo-Anne Pinson, Menachem J. Gunzburg, Catherine F. Latham, Nicholas Barlow, George W. Mbogo, Paula Ellenberg, Stephen J. Headey, Nicolas Sluis-Cremer, David Tyssen, Joseph D. Bauman, Francesc X. Ruiz, Eddy Arnold, David K. Chalmers, Gilda Tachedjian
Publikováno v:
Molecules, Vol 28, Iss 7, p 3103 (2023)
Human immunodeficiency virus type I (HIV-1) is a retrovirus that infects cells of the host’s immune system leading to acquired immunodeficiency syndrome and potentially death. Although treatments are available to prevent its progression, HIV-1 rema
Externí odkaz:
https://doaj.org/article/c7cd4c19945d4662b4ccbad1fae4b33e
Autor:
Luke A. Adams, Lorna E. Wilkinson-White, Menachem J. Gunzburg, Stephen J. Headey, Biswaranjan Mohanty, Martin J. Scanlon, Ben Capuano, Joel P. Mackay, Bradley C. Doak
Publikováno v:
Journal of Medicinal Chemistry. 66:5859-5872
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de010768ec5512cd1a8a32538465d72f
https://doi.org/10.1021/acs.jmedchem.3c00137
https://doi.org/10.1021/acs.jmedchem.3c00137
Autor:
Adam J. Vogrin, Neil I. Bower, Menachem J. Gunzburg, Sally Roufail, Kazuhide S. Okuda, Scott Paterson, Stephen J. Headey, Steven A. Stacker, Benjamin M. Hogan, Marc G. Achen
Publikováno v:
Cell Reports, Vol 28, Iss 8, Pp 2023-2036.e4 (2019)
Summary: Lymphatic vascular development establishes embryonic and adult tissue fluid balance and is integral in disease. In diverse vertebrate organs, lymphatic vessels display organotypic function and develop in an organ-specific manner. In all sett
Externí odkaz:
https://doaj.org/article/4ff63854e2ad428099b435bfa53eb1db
Autor:
Biswaranjan Mohanty, Kieran Rimmer, Róisín M McMahon, Stephen J Headey, Mansha Vazirani, Stephen R Shouldice, Mathieu Coinçon, Stephanie Tay, Craig J Morton, Jamie S Simpson, Jennifer L Martin, Martin J Scanlon
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173436 (2017)
At a time when the antibiotic drug discovery pipeline has stalled, antibiotic resistance is accelerating with catastrophic implications for our ability to treat bacterial infections. Globally we face the prospect of a future when common infections ca
Externí odkaz:
https://doaj.org/article/622b291cbc23439dad3506ecbeaf3d70
Autor:
Zorik Chilingaryan, Stephen J. Headey, Allen T. Y. Lo, Zhi-Qiang Xu, Gottfried Otting, Nicholas E. Dixon, Martin J. Scanlon, Aaron J. Oakley
Publikováno v:
Antibiotics, Vol 7, Iss 1, p 14 (2018)
In bacteria, the DnaG primase is responsible for synthesis of short RNA primers used to initiate chain extension by replicative DNA polymerase(s) during chromosomal replication. Among the proteins with which Escherichia coli DnaG interacts is the sin
Externí odkaz:
https://doaj.org/article/9c5e2099c6f7403fa551c8523a04181d
Autor:
Martin J. Scanlon, Ben Capuano, Lorna Wilkinson-White, Bradley C. Doak, Stephen J. Headey, Menachem J. Gunzburg, Joel P. Mackay, Luke A. Adams
The development of low-affinity fragment hits into higher affinity leads is a major hurdle in fragment-based drug design. Here we demonstrate an approach for the Rapid Elaboration of Fragments into Leads (REFiL) applying an integrated workflow that p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ea2d21a7e1661748dc4e9d99108608f
https://doi.org/10.26434/chemrxiv.12026952.v1
https://doi.org/10.26434/chemrxiv.12026952.v1
Autor:
Maite Amado, Tzong-Hsien Lee, Martin J. Scanlon, Jennifer R. Deuis, Brian A. Baldo, Dianne Alewood, Alysha G. Elliott, Zoltan Dekan, Paul F. Alewood, Stephen J. Headey, Marie-Isabel Aguilar, Irina Vetter, Mark E. Cooper
Publikováno v:
Angewandte Chemie International Edition. 56:8495-8499
Delta-Myrtoxin-Mp1a (Mp1a), a 49-residue heterodimeric peptide from the venom of Myrmecia pilosula, comprises a 26-mer A chain and a 23-mer B chain connected by two disulfide bonds in an antiparallel arrangement. Combination of the individual synthet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf555a321d69b7f9ccf615130877e28b
https://doi.org/10.1002/anie.201703360
https://doi.org/10.1002/anie.201703360
Autor:
Hassan Benameur, Christopher J.H. Porter, David K. Chalmers, Woldeamanuel A. Birru, Dallas B. Warren, Stephen J. Headey, Colin W. Pouton
Publikováno v:
Molecular Pharmaceutics. 14:566-579
Improved models of the gastrointestinal environment have great potential to assist the complex process of drug formulation. Molecular dynamics (MD) is a powerful method for investigating phase behavior at a molecular level. In this study we use multi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df6b1cd5c554fefb1482459e0eb40062
https://doi.org/10.1021/acs.molpharmaceut.6b00888
https://doi.org/10.1021/acs.molpharmaceut.6b00888
Autor:
Richard J. Weaver, Biswaranjan Mohanty, Michelle L. Halls, Patrick Genissel, Craig Steven Clements, Laurent Vuillard, Christopher J.H. Porter, Indu R. Chandrashekaran, Rahul Chandrakant Patil, Bradley C. Doak, Martin Williams, Stephen J. Headey, O.V. Ilyichova, Bonan Liu, Martin J. Scanlon
Peroxisome proliferator–activated receptor α (PPARα) is a transcriptional regulator of lipid metabolism. GW7647 is a potent PPARα agonist that must reach the nucleus to activate this receptor. In cells expressing human fatty acid–binding prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6d0cd4ce2d9bfc97952bae843ac2ca7
https://europepmc.org/articles/PMC6416440/
https://europepmc.org/articles/PMC6416440/
Autor:
Martin J. Scanlon, Stephen J. Headey, Stephen P. Bottomley, Amy L. Robertson, Robert N. Pike, Lakshmi C. Wijeyewickrema, Natasha M. Ng
Publikováno v:
Biochimie. 122:227-234
Proteolysis has a critical role in transmitting information within a biological system and therefore an important element of biology is to determine the subset of proteins amenable to proteolysis. Until recently, it has been thought that proteases cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::042be4f00d636de725929a7416228594
https://doi.org/10.1016/j.biochi.2015.09.021
https://doi.org/10.1016/j.biochi.2015.09.021