Zobrazeno 1 - 10
of 273
pro vyhledávání: '"Stephen J, Blanksby"'
Autor:
Aurélie H. Benfield, Felicitas Vernen, Reuben S.E. Young, Ferran Nadal-Bufí, Henry Lamb, Heinz Hammerlindl, David J. Craik, Helmut Schaider, Nicole Lawrence, Stephen J. Blanksby, Sónia Troeira Henriques
Publikováno v:
Pharmacological Research, Vol 207, Iss , Pp 107298- (2024)
Acquired drug resistance is the major cause for disease recurrence in cancer patients, and this is particularly true for patients with metastatic melanoma that carry a BRAF V600E mutation. To address this problem, we investigated cyclic membrane-acti
Externí odkaz:
https://doaj.org/article/50785ac1b6184083804b7912b18f5e8f
Autor:
Jan Philipp Menzel, Reuben S. E. Young, Aurélie H. Benfield, Julia S. Scott, Puttandon Wongsomboon, Lukáš Cudlman, Josef Cvačka, Lisa M. Butler, Sónia T. Henriques, Berwyck L. J. Poad, Stephen J. Blanksby
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Fatty acid isomers are responsible for an under-reported lipidome diversity across all kingdoms of life. Isomers of unsaturated fatty acids are often masked in contemporary analysis by incomplete separation and the absence of sufficiently di
Externí odkaz:
https://doaj.org/article/b36684f72a654a7ba6e2ec40d5933f90
Autor:
Reuben S.E. Young, Andrew P. Bowman, Kaylyn D. Tousignant, Berwyck L.J. Poad, Jennifer H. Gunter, Lisa K. Philp, Colleen C. Nelson, Shane R. Ellis, Ron M.A. Heeren, Martin C. Sadowski, Stephen J. Blanksby
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 6, Pp 100223- (2022)
The cellular energy and biomass demands of cancer drive a complex dynamic between uptake of extracellular FAs and their de novo synthesis. Given that oxidation of de novo synthesized FAs for energy would result in net-energy loss, there is an implica
Externí odkaz:
https://doaj.org/article/fee2b5d060ce47b7a34577bf15b24534
Autor:
Lukáš Cudlman, Aleš Machara, Vladimír Vrkoslav, Miroslav Polášek, Zuzana Bosáková, Stephen J. Blanksby, Josef Cvačka
Publikováno v:
Biomolecules, Vol 13, Iss 3, p 475 (2023)
Triacylglycerol estolides (TG-EST) are biologically active lipids extensively studied for their anti-inflammatory and anti-diabetic properties. In this work, eight standards of TG-EST were synthesized and systematically investigated by nanoelectrospr
Externí odkaz:
https://doaj.org/article/4cc295303cfa422aa9cacf76b3f54d9a
Therapy-induced lipid uptake and remodeling underpin ferroptosis hypersensitivity in prostate cancer
Autor:
Kaylyn D. Tousignant, Anja Rockstroh, Berwyck L. J. Poad, Ali Talebi, Reuben S. E. Young, Atefeh Taherian Fard, Rajesh Gupta, Tuo Zang, Chenwei Wang, Melanie L. Lehman, Johan V. Swinnen, Stephen J. Blanksby, Colleen C. Nelson, Martin C. Sadowski
Publikováno v:
Cancer & Metabolism, Vol 8, Iss 1, Pp 1-21 (2020)
Abstract Background Metabolic reprograming, non-mutational epigenetic changes, increased cell plasticity, and multidrug tolerance are early hallmarks of therapy resistance in cancer. In this temporary, therapy-tolerant state, cancer cells are highly
Externí odkaz:
https://doaj.org/article/c6e2a3ea96274cda8079bc82f329c973
Autor:
Reuben S. E. Young, Britt S. R. Claes, Andrew P. Bowman, Elizabeth D. Williams, Benjamin Shepherd, Aurel Perren, Berwyck L. J. Poad, Shane R. Ellis, Ron M. A. Heeren, Martin C. Sadowski, Stephen J. Blanksby
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Prostate cancer is the fourth most common cancer worldwide with definitive diagnosis reliant on biopsy and human-graded histopathology. As with other pathologies, grading based on classical haematoxylin and eosin (H&E) staining of formalin fixed para
Externí odkaz:
https://doaj.org/article/1230b39ffff14ef29ef2632067fc8981
Autor:
Sarah E. Hancock, Berwyck L.J. Poad, Mark D.P. Willcox, Stephen J. Blanksby, Todd W. Mitchell
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 11, Pp 1968-1978 (2019)
Secretions from meibomian glands located within the eyelid (commonly known as meibum) are rich in nonpolar lipid classes incorporating very-long (22–30 carbons) and ultra-long (>30 carbons) acyl chains. The complex nature of the meibum lipidome and
Externí odkaz:
https://doaj.org/article/a4796cc143c346df9602efed9061c8ab
Autor:
Reuben S.E. Young, Andrew P. Bowman, Elizabeth D. Williams, Kaylyn D. Tousignant, Charles L. Bidgood, Venkateswara R. Narreddula, Rajesh Gupta, David L. Marshall, Berwyck L.J. Poad, Colleen C. Nelson, Shane R. Ellis, Ron M.A. Heeren, Martin C. Sadowski, Stephen J. Blanksby
Publikováno v:
Cell Reports, Vol 34, Iss 6, Pp 108738- (2021)
Summary: Canonical fatty acid metabolism describes specific enzyme-substrate interactions that result in products with well-defined chain lengths, degree(s), and positions of unsaturation. Deep profiling of lipids across a range of prostate cancer ce
Externí odkaz:
https://doaj.org/article/27b8a1a8bbb5417e805cadd5a720a7a8
Autor:
Tyler Fahrenhorst-Jones, David L. Marshall, Jed. M. Burns, Gregory K. Pierens, Robert E. Hormann, Allison M. Fisher, Paul V. Bernhardt, Stephen J. Blanksby, G. Paul Savage, Philip E. Eaton, Craig M. Williams
Publikováno v:
Chemical Science. 14:2821-2825
1-Azahomocubane has been prepared 56 years after the parent hydrocarbon. Introduction of a nitrogen atom into this constrained polycyclic environment resulted in minimal changes to the framework geometry, with s-character of the nitrogen lone pair in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca5fc35dd6725ef4ebb7fbf3ef4c62ec
https://doi.org/10.1039/d3sc00001j
https://doi.org/10.1039/d3sc00001j
Autor:
Fernando Martínez-Montañés, Albert Casanovas, Richard R. Sprenger, Magdalena Topolska, David L. Marshall, Marta Moreno-Torres, Berwyck L.J. Poad, Stephen J. Blanksby, Martin Hermansson, Ole N. Jensen, Christer S. Ejsing
Publikováno v:
Cell Reports, Vol 32, Iss 6, Pp 108024- (2020)
Summary: The ability to remodel lipid metabolism under changing conditions is pivotal for cellular functionality and homeostasis. Here, we characterize the regulatory landscape of phosphorylation-based signaling events across the life cycle of Saccha
Externí odkaz:
https://doaj.org/article/c5ea7ca592024eb0a1b9cd19cf2ab979