Three dimensional visualization and fractal analysis of mosaic patches in rat chimeras: cell assortment in liver, adrenal cortex and cornea.

Autor: Stephen Iannaccone, Yue Zhou, David Walterhouse, Greg Taborn, Gabriel Landini, Philip Iannaccone

Publikováno v: PLoS ONE, Vol 7, Iss 2, p e31609 (2012)

The production of organ parenchyma in a rapid and reproducible manner is critical to normal development. In chimeras produced by the combination of genetically distinguishable tissues, mosaic patterns of cells derived from the combined genotypes can

Externí odkaz: https://doaj.org/article/5885909b818945b18297946e4ad10cce

iPSC-derived progenitor stromal cells provide new insights into aberrant musculoskeletal development and resistance to cancer in down syndrome

Autor: Irina Elcheva, Mariana Perepitchka, Vasiliy Galat, Stephen Iannaccone, Philip M. Iannaccone, Yekaterina Galat

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports

Down syndrome (DS) is a congenital disorder caused by trisomy 21 (T21). It is associated with cognitive impairment, muscle hypotonia, heart defects, and other clinical anomalies. At the same time, individuals with Down syndrome have lower prevalence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32ab7681c65fd43d42756a30eecd823c
http://link.springer.com/article/10.1038/s41598-020-69418-9

Regulation of GLI1 by cis DNA elements and epigenetic marks

Autor: David J. Robbins, Robert L. Taylor, Kathrine B. Sylvestersen, Stephen Iannaccone, Ronnie Childs, King Fu Leong, Joon Won Yoon, David O. Walterhouse, Jun Long, Philip M. Iannaccone, Michael L. Nielsen

Publikováno v: Taylor, R, Long, J, Yoon, J W, Childs, R, Sylvestersen, K B, Nielsen, M L, Leong, K-F, Iannaccone, S, Walterhouse, D O, Robbins, D J & Iannaccone, P 2019, ' Regulation of GLI1 by cis DNA elements and epigenetic marks ', DNA Repair, vol. 79, pp. 10-21 . https://doi.org/10.1016/j.dnarep.2019.04.011
DNA repair

GLI1 is one of three transcription factors (GLI1, GLI2 and GLI3) that mediate the Hedgehog signal transduction pathway and play important roles in normal development. GLI1 and GLI2 form a positive-feedback loop and function as human oncogenes. The mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5f513f01ed19892e9a068d8432c2d4d
https://doi.org/10.1016/j.dnarep.2019.04.011

Developmental Potential of Rat Extraembryonic Stem Cells

Autor: Philip M. Iannaccone, Stephen Iannaccone, Bisrat G. Debeb, Bert Binas, Vasiliy Galat, Lynne-Marie Postovit

Publikováno v: Stem Cells and Development. 18:1309-1318

We have previously found that certain stem cells that are derived from rat blastocysts and named extraembryonic endoderm precursor (XEN-P) cells show a unique molecular signature sharing some of the characteristics of embryonic stem cells (ES), troph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95048a59f0a4cc3a51087e9271e61f44
https://doi.org/10.1089/scd.2009.0115

Defining a role for Sonic hedgehog pathway activation in desmoplastic medulloblastoma by identifying GLI1 target genes

Autor: Stephen Iannaccone, Philip M. Iannaccone, Richard J. Gilbertson, David O. Walterhouse, Joon Won Yoon

A subgroup of medulloblastomas shows constitutive activation of the Sonic hedgehog pathway with expression of GLI1. We identified the subset of GLI1 transforming target genes specifically expressed in medulloblastomas by comparing GLI1 targets in RK3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccf99d40f4707c6ab4b055a80df2c148
https://europepmc.org/articles/PMC3889649/