Zobrazeno 1 - 10
of 277
pro vyhledávání: '"Stephen I. Alexander"'
Autor:
Qi Cao, Ruifeng Wang, Zhiguo Niu, Titi Chen, Farhana Azmi, Scott A. Read, Jianwei Chen, Vincent W.S. Lee, Chunze Zhou, Sohel Julovi, Qingsong Huang, Yuan Min Wang, Malcolm R. Starkey, Guoping Zheng, Stephen I. Alexander, Jacob George, Yiping Wang, David C.H. Harris
Publikováno v:
JHEP Reports, Vol 5, Iss 10, Pp 100837- (2023)
Background and Aims: Although type 2 innate lymphoid cells (ILC2s) were originally found to be liver-resident lymphocytes, the role and importance of ILC2 in liver injury remains poorly understood. In the current study, we sought to determine whether
Externí odkaz:
https://doaj.org/article/69039427e9784e949ef473beddbc32b2
Autor:
Anita van Zwieten, Elizabeth G. Ryan, Patrina Caldwell, Kirsten Howard, Allison Tong, Jonathan C. Craig, Stephen I. Alexander, Martin Howell, Armando Teixeira-Pinto, Carmel M. Hawley, Shilpanjali Jesudason, Amanda Walker, Fiona Mackie, Sean E. Kennedy, Steven McTaggart, Hugh J. McCarthy, Simon A. Carter, Siah Kim, Reginald Woodleigh, Anna Francis, Alistair R. Mallard, Amélie Bernier-Jean, David W. Johnson, Deirdre Hahn, Donna Reidlinger, Elaine Pascoe, Julie Varghese, Charani Kiriwandeniya, Liza Vergara, Nicholas Larkins, Luke Macauley, Michelle Irving, Rabia Khalid, Chandana Guha, Germaine Wong
Publikováno v:
Trials, Vol 23, Iss 1, Pp 1-4 (2022)
Abstract Background This update summarises key changes made to the protocol since the publication of the original protocol for the NAVKIDS2 trial of patient navigators for children with chronic kidney disease (CKD) experiencing social disadvantage an
Externí odkaz:
https://doaj.org/article/e9aefbd2b33b4ee98efbd4bb646dec48
Membranous nephropathy: Clearer pathology and mechanisms identify potential strategies for treatment
Autor:
Edmund Y. M. Chung, Yuan M. Wang, Karen Keung, Min Hu, Hugh McCarthy, Germaine Wong, Lukas Kairaitis, Bhadran Bose, David C. H. Harris, Stephen I. Alexander
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Primary membranous nephropathy (PMN) is one of the common causes of adult-onset nephrotic syndrome and is characterized by autoantibodies against podocyte antigens causing in situ immune complex deposition. Much of our understanding of the disease me
Externí odkaz:
https://doaj.org/article/63b3e0f3ce6647be968811c2b01df918
Autor:
Edmund Y. M. Chung, MD, Katrina Blazek, BMedSci, Armando Teixeira-Pinto, PhD, Ankit Sharma, PhD, Siah Kim, PhD, Yingxin Lin, PhD, Karen Keung, PhD, Bhadran Bose, MBBS, Lukas Kairaitis, PhD, Hugh McCarthy, PhD, Pierre Ronco, PhD, Stephen I. Alexander, MD, Germaine Wong, PhD
Publikováno v:
Transplantation Direct, Vol 8, Iss 9, p e1357 (2022)
Background. Recurrent membranous nephropathy (MN) posttransplantation affects 35% to 50% of kidney transplant recipients (KTRs) and accounts for 50% allograft loss 5 y after diagnosis. Predictive factors for recurrent MN may include HLA-D risk allele
Externí odkaz:
https://doaj.org/article/be8d4697ae2c4af78ad7b0e22122bbcc
Autor:
Hope A. Tanudisastro, Katherine Holman, Gladys Ho, Elizabeth Farnsworth, Katrina Fisk, Thet Gayagay, Emma Hackett, Gemma Jenkins, Rahul Krishnaraj, Tiffany Lai, Karen Wong, Chirag Patel, Amali Mallawaarachchi, Andrew J. Mallett, Bruce Bennetts, Stephen I. Alexander, Hugh J. McCarthy
Publikováno v:
npj Genomic Medicine, Vol 6, Iss 1, Pp 1-9 (2021)
Abstract Genetic testing in nephrology clinical practice has moved rapidly from a rare specialized test to routine practice both in pediatric and adult nephrology. However, clear information pertaining to the likely outcome of testing is still missin
Externí odkaz:
https://doaj.org/article/a7423469dafd4c0d913a4f96c90d30b8
Autor:
Edmund Y. M. Chung, Katie Trinh, Jennifer Li, Sebastian Hayden Hahn, Zoltan H. Endre, Natasha M. Rogers, Stephen I. Alexander
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Heart and kidney failure often co-exist and confer high morbidity and mortality. The complex bi-directional nature of heart and kidney dysfunction is referred to as cardiorenal syndrome, and can be induced by acute or chronic dysfunction of either or
Externí odkaz:
https://doaj.org/article/43499c857416413bb4cd0ac53dfb06a9
Autor:
Min Hu, Natasha M. Rogers, Jennifer Li, Geoff Y. Zhang, Yuan Min Wang, Karli Shaw, Philip J. O’Connell, Stephen I. Alexander
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Kidney transplantation is the most common solid organ transplant and the best current therapy for end-stage kidney failure. However, with standard immunosuppression, most transplants develop chronic dysfunction or fail, much of which is due to chroni
Externí odkaz:
https://doaj.org/article/ecb83d74e7f046119e2c13eb4a1ef329
Autor:
Rui Wang, Shi-Ting Wu, Xi Yang, Yude Qian, Jaesung P. Choi, Rui Gao, Siliang Song, Yixuan Wang, Tao Zhuang, Justin J.L. Wong, Yuzhen Zhang, Zhiming Han, Hua A. Lu, Stephen I. Alexander, Renjing Liu, Yin Xia, Xiangjian Zheng
Publikováno v:
JCI Insight, Vol 6, Iss 12 (2021)
PDCD10, also known as CCM3, is a gene found to be associated with the human disease cerebral cavernous malformations (CCMs). PDCD10 forms a complex with GCKIII kinases including STK24, STK25, and MST4. Studies in C. elegans and Drosophila have shown
Externí odkaz:
https://doaj.org/article/e5ed75a8f8f3429a87e0002ff0c594a2
Autor:
Titi Chen, Qi Cao, Ruifeng Wang, Guoping Zheng, Farhana Azmi, Jeffery Wang, Vincent W. Lee, Yuan Min Wang, Hong Yu, Manish Patel, Chow Heok P’ng, Stephen I. Alexander, Natasha M. Rogers, Yiping Wang, David C. H. Harris
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
BackgroundcDC1 is a subset of conventional DCs, whose most recognized function is cross-presentation to CD8+ T cells. We conducted this study to investigate the number and location of cDC1s in various human kidney diseases as well as their correlatio
Externí odkaz:
https://doaj.org/article/b7923b37c60845b1aba09162dd7a5244
Autor:
Simon H. Jiang, Vicki Athanasopoulos, Julia I. Ellyard, Aaron Chuah, Jean Cappello, Amelia Cook, Savit B. Prabhu, Jacob Cardenas, Jinghua Gu, Maurice Stanley, Jonathan A. Roco, Ilenia Papa, Mehmet Yabas, Giles D. Walters, Gaetan Burgio, Kathryn McKeon, James M. Byers, Charlotte Burrin, Anselm Enders, Lisa A. Miosge, Pablo F. Canete, Marija Jelusic, Velibor Tasic, Adrian C. Lungu, Stephen I. Alexander, Arthur R. Kitching, David A. Fulcher, Nan Shen, Todor Arsov, Paul A. Gatenby, Jeff J. Babon, Dominic F. Mallon, Carmen de Lucas Collantes, Eric A. Stone, Philip Wu, Matthew A. Field, Thomas D. Andrews, Eun Cho, Virginia Pascual, Matthew C. Cook, Carola G. Vinuesa
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Function-altering variants of immune-related genes cause rare autoimmune syndromes, whereas their contribution to common autoimmune diseases remains uncharacterized. Here the authors show that rare variants of lupus-associated genes are present in th
Externí odkaz:
https://doaj.org/article/78a180011b6f49c096a0159adcd221f4