A kinase inhibitor screen identifies signaling pathways regulating mucosal growth during otitis media.

Autor: Julia Noel, Keigo Suzukawa, Eduardo Chavez, Kwang Pak, Stephen I Wasserman, Arwa Kurabi, Allen F Ryan

Publikováno v: PLoS ONE, Vol 15, Iss 8, p e0235634 (2020)

Otitis media, the most common disease of childhood, is characterized by extensive changes in the morphology of the middle ear cavity. This includes hyperplasia of the mucosa that lines the tympanic cavity, from a simple monolayer of squamous epitheli

Externí odkaz: https://doaj.org/article/0ed6d12e61884325bcca9647cca1ff00

A mouse model of otitis media identifies HB-EGF as a mediator of inflammation-induced mucosal proliferation.

Autor: Keigo Suzukawa, Julia Tomlin, Kwang Pak, Eduardo Chavez, Arwa Kurabi, Andrew Baird, Stephen I Wasserman, Allen F Ryan

Publikováno v: PLoS ONE, Vol 9, Iss 7, p e102739 (2014)

Otitis media is one of the most common pediatric infections. While it is usually treated without difficulty, up to 20% of children may progress to long-term complications that include hearing loss, impaired speech and language development, academic u

Externí odkaz: https://doaj.org/article/7bb68e8b005d4da6b36bf22786dc603c

Obesity's effect on asthma extends to diagnostic criteria

Autor: Siyun Yang, Mario Castro, Kevin J. Anstrom, Stephen C. Lazarus, Tonya S. King, Homer A. Boushey, Richard J. Martin, Cynthia L. Green, Siyi Zhang, William J. Calhoun, Susan J. Kunselman, Run Zhou, Stephen I. Wasserman, Nikolina Icitovic, Njira L Lugogo, Elliot Israel, Susanne Meghdadpour, Vernon M. Chinchilli, Robert F. Lemanske, Stephen P. Peters, Noah Agada, Monica Kraft, Emily DiMango

Publikováno v: The Journal of allergy and clinical immunology, vol 141, iss 3

BackgroundThe use of inflammatory biomarkers to delineate the type of lung inflammation present in asthmatic subjects is increasingly common. However, the effect of obesity on these markers is unknown.ObjectivesWe aimed to determine the effect of obe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21d656bba73308e6faa22962768fa44a
https://doi.org/10.1016/j.jaci.2017.04.047

Test Performance Characteristics of the AIR, GAD-7, and HADS-Anxiety Screening Questionnaires for Anxiety in Chronic Obstructive Pulmonary Disease

Autor: Anna M. Baker, Janet T. Holbrook, Abebaw M. Yohannes, Michelle N. Eakin, Elizabeth A. Sugar, Robert J. Henderson, Anne S. Casper, David A. Kaminsky, Alexis L. Rea, Anne M. Mathews, Loretta G. Que, Joe W. Ramsdell, Lynn B. Gerald, Robert A. Wise, Nicola A. Hanania, Nicola Hanania, Marianna Sockrider, Laura Bertrand, Mustafa Atik, Blanca A. Lopez, Joan Reibman, Emily DiMango, Linda Rogers, Karen Carapetyan, Kristina Rivera, Melissa Scheuerman, Elizabeth Fiorino, Newel Bryce-Robinson, Deanna Green, Robert Noveck, Catherine Foss, Jessica Ghidorzi, Zongyao Wang, Elise Pangborn, V. Susan Robertson, Nicholas Eberlein, Jane Stiles, Michael Land, Brian Vickery, Eveline Wu, Denise Jaggers, Stephanie Allen, Sabrena Mervin-Blake, Lewis Smith, Ravi Kalhan, James Moy, Edward Naureckas, Jenny Hixon, Zenobia Gonsalves, Virginia Zagaja, Jennifer Kustwin, Ben Xu, Thomas Matthews, Lucius Robinson, Noopur Singh, Kyle Happel, Marie C. Sandi, Jennifer M. Graham, Katelyn Sullivan, Elizabeth Poretta, Rohit Katial, Flavia Hoyte, Maria Rojas, Mario Castro, Leonard B. Bacharier, Kaharu Sumino, Roger D. Yusen, Jaime J. Tarsi, Brenda Patterson, Terri Montgomery, Michael Busk, Debra Weiss, Kimberly Sundblad, Charles Irvin, Anne E. Dixon, Charlotte Teneback, Jothi Kanagalingam, Stephanie M. Burns, Kathleen Dwinell, James L. Goodwin, Mark A. Brown, Tara F. Carr, Cristine E. Berry, Christian Bime, Mark A. Goforth, Elizabeth A. Ryan, Jesus A. Wences, Silvia L. Lopez, Janette C. Priefert, Natalie S. Provencio-Dean, Destinee R. Ogas, Valerie R. Bloss, Stephen I. Wasserman, Xavier T. Soler, Katie H. Kinninger, Amber J. Martineau, Tonya Greene, Samang Ung, Adam Wanner, Richard Lockey, Thomas B. Casale, Andreas Schmid, Michael Campos, Monroe King, Eliana S. Mendes, Catherine Renee Smith, Jeaneen Ahmad, Patricia D. Rebolledo, Johana Arana, Lilian Cadet, Shawna Atha, Rebecca McCrery, Sarah M. Croker, Gary Salzman, Asem Abdeljalil, Abid Bhat, Ashraf Gohar, Mary Reed, W. Gerald Teague, Larry Borish, Kristin W Wavell, Theresa A. Altherr, Donna Wolf, Shahleen Ahmed, William C. Bailey, Robert Wise, Janet Holbrook, Alexis Rea, Joy Saams, Bethany Grove, Adante Hart, Andrea Lears, Deborah Nowakowski, David Shade, Elizabeth Sugar, Anne Shanklin Casper, Lea T. Drye, Vernon M. Chinchilli, Paul N. Lanken, Donald P. Tashkin, Alexandra Sierra, Norman H. Edelman, Susan Rappaport, Elizabeth Lancet

Publikováno v: Ann Am Thorac Soc

Rationale: Anxiety is a common comorbidity of chronic obstructive pulmonary disease (COPD) that is associated with higher morbidity and mortality. We evaluated three anxiety screening questionnaires: the Generalized Anxiety Disorder 7-Item Scale (GAD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e46ad5c4a925b6b6c4ad6c76218e71f
https://pubmed.ncbi.nlm.nih.gov/29986152

Lipoxin Generation Is Related to Soluble Epoxide Hydrolase Activity in Severe Asthma

Autor: Emiko, Ono, Stefanie, Dutile, Shamsah, Kazani, Michael E, Wechsler, Jun, Yang, Bruce D, Hammock, David Nobuhiro, Douda, Yacine, Tabet, Rayan, Khaddaj-Mallat, Marco, Sirois, Chantal, Sirois, Edmond, Rizcallah, Eric, Rousseau, Richard, Martin, E Rand, Sutherland, Mario, Castro, Nizar N, Jarjour, Elliot, Israel, Bruce D, Levy, Stephen I, Wasserman

Publikováno v: American Journal of Respiratory and Critical Care Medicine. 190:886-897

Rationale: Severe asthma is characterized by airway inflammatory responses associated with aberrant metabolism of arachidonic acid. Lipoxins (LX) are arachidonate-derived pro-resolving mediators that are decreased in severe asthma, yet mechanisms for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d30ec9e60082553c615b73ada8bfa97
https://doi.org/10.1164/rccm.201403-0544oc