Zobrazeno 1 - 10
of 136
pro vyhledávání: '"Stephen Henderson"'
Autor:
Ankur Chakravarthy, Ian Reddin, Stephen Henderson, Cindy Dong, Nerissa Kirkwood, Maxmilan Jeyakumar, Daniela Rothschild Rodriguez, Natalia Gonzalez Martinez, Jacqueline McDermott, Xiaoping Su, Nagayasau Egawa, Christina S. Fjeldbo, Vilde Eide Skingen, Heidi Lyng, Mari Kyllesø Halle, Camilla Krakstad, Afschin Soleiman, Susanne Sprung, Matt Lechner, Peter J. I. Ellis, Mark Wass, Martin Michaelis, Heidi Fiegl, Helga Salvesen, Gareth J. Thomas, John Doorbar, Kerry Chester, Andrew Feber, Tim R. Fenton
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Human papillomavirus (HPV) is a known cause of cervical cancer. Here, the authors perform a multi-omic analysis using published cervical squamous cell carcinoma cohorts from the USA, Europe, and SubSaharan Africa and identify two cervical squamous ce
Externí odkaz:
https://doaj.org/article/9a5c4607e718467ca9be497358a18ce0
Autor:
Heather C. West, James Davies, Stephen Henderson, Oluyori K. Adegun, Sophie Ward, Ivana R. Ferrer, Chanidapa A. Tye, Andres F. Vallejo, Laura Jardine, Matthew Collin, Marta E. Polak, Clare L. Bennett
Publikováno v:
Cell Reports, Vol 39, Iss 7, Pp 110819- (2022)
Summary: T cell pathology in the skin leads to monocyte influx, but we have little understanding of the fate of recruited cells within the diseased niche, or the long-term impact on cutaneous immune homeostasis. By combining a murine model of acute g
Externí odkaz:
https://doaj.org/article/960eba7bb8e8431f8c5a9ff4e7e81b08
Autor:
Anne E Roehrig, Kristina Klupsch, Juan A Oses-Prieto, Selim Chaib, Stephen Henderson, Warren Emmett, Lucy C Young, Silvia Surinova, Andreas Blees, Anett Pfeiffer, Maha Tijani, Fabian Brunk, Nicole Hartig, Marta Muñoz-Alegre, Alexander Hergovich, Barbara H Jennings, Alma L Burlingame, Pablo Rodriguez-Viciana
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0254697 (2021)
The PAF complex (PAFC) coordinates transcription elongation and mRNA processing and its CDC73/parafibromin subunit functions as a tumour suppressor. The NF2/Merlin tumour suppressor functions both at the cell cortex and nucleus and is a key mediator
Externí odkaz:
https://doaj.org/article/060b7e02b03d49888281c2e401c2133d
Autor:
Matteo Vietri Rudan, Christopher Barrington, Stephen Henderson, Christina Ernst, Duncan T. Odom, Amos Tanay, Suzana Hadjur
Publikováno v:
Cell Reports, Vol 10, Iss 8, Pp 1297-1309 (2015)
Topological domains are key architectural building blocks of chromosomes, but their functional importance and evolutionary dynamics are not well defined. We performed comparative high-throughput chromosome conformation capture (Hi-C) in four mammals
Externí odkaz:
https://doaj.org/article/cc59aeeb53de47679cf94e6a2d71441c
Autor:
Ohad Yogev, Stephen Henderson, Matthew John Hayes, Sara Sofia Marelli, Yifat Ofir-Birin, Neta Regev-Rudzki, Javier Herrero, Tariq Enver
Publikováno v:
PLoS Pathogens, Vol 13, Iss 8, p e1006524 (2017)
Metabolic changes within the cell and its niche affect cell fate and are involved in many diseases and disorders including cancer and viral infections. Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi's sarcoma (KS).
Externí odkaz:
https://doaj.org/article/977bd5e63b2b41e98d99c37db8322f20
Autor:
Katrina Soderquest, Arnulf Hertweck, Claudia Giambartolomei, Stephen Henderson, Rami Mohamed, Rimma Goldberg, Esperanza Perucha, Lude Franke, Javier Herrero, Vincent Plagnol, Richard G Jenner, Graham M Lord
Publikováno v:
PLoS Genetics, Vol 13, Iss 2, p e1006587 (2017)
The polarization of CD4+ T cells into distinct T helper cell lineages is essential for protective immunity against infection, but aberrant T cell polarization can cause autoimmunity. The transcription factor T-bet (TBX21) specifies the Th1 lineage an
Externí odkaz:
https://doaj.org/article/1b047c1f9aaf46738e2b7b4684f706e9
Publikováno v:
Cell Reports, Vol 7, Iss 6, Pp 1833-1841 (2014)
APOBEC3B cytosine deaminase activity has recently emerged as a significant mutagenic factor in human cancer. APOBEC activity is induced in virally infected cells, and APOBEC signature mutations occur at high frequency in cervical cancers (CESC), over
Externí odkaz:
https://doaj.org/article/f206e1c685524a278c6bf04162cb2729
Autor:
Rebecca C Robey, Dimitrios Lagos, Fiona Gratrix, Stephen Henderson, Nick C Matthews, Richard J Vart, Mark Bower, Chris Boshoff, Frances M Gotch
Publikováno v:
PLoS ONE, Vol 4, Iss 6, p e5890 (2009)
Kaposi's sarcoma-associated herpesvirus (KSHV) is causally related to Kaposi's sarcoma (KS), the most common malignancy in untreated individuals with HIV/AIDS. The adaptive T-cell immune response against KSHV has not been fully characterized. To achi
Externí odkaz:
https://doaj.org/article/7634a9f174c849208c374355c5b934b4
Autor:
Lucia Cottone, Lorena Ligammari, Hang-Mao Lee, Helen J. Knowles, Stephen Henderson, Sara Bianco, Christopher Davies, Sandra Strauss, Fernanda Amary, Ana Paula Leite, Roberto Tirabosco, Kristian Haendler, Joachim L. Schultze, Javier Herrero, Paul O’Donnell, Agamemnon E. Grigoriadis, Paolo Salomoni, Adrienne M. Flanagan
Publikováno v:
Cell death and differentiation 29(12), 2459-2471 (2022). doi:10.1038/s41418-022-01031-x
Oncohistones represent compelling evidence for a causative role of epigenetic perturbations in cancer. Giant cell tumours of bone (GCTs) are characterised by a mutated histone H3.3 as the sole genetic driver present in bone-forming osteoprogenitor ce
Autor:
Marc R. Mansour, Robertus A.M. de Bruin, David C. Linch, Javier Herrero, Stephen Henderson, Elisabeth P. Nacheva, Rajeev Gupta, José Afonso Guerra-Assunção, Sara Ahrabi, Simon E. Richardson, Nadine Farah, Brian Philip, Michael Magnussen, Sunniyat Rahman, Cosetta Bertoli, Tanya Rapoz-D'Silva, Theresa E. León
Loss-of-function mutations of EZH2, the enzymatic component of PRC2, have been associated with poor outcome and chemotherapy resistance in T-cell acute lymphoblastic leukemia (T-ALL). Using isogenic T-ALL cells, with and without CRISPR/Cas9–induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4089bdc0a61ebcf86d1dc460a116dd79
https://doi.org/10.1158/2159-8290.c.6547820.v1
https://doi.org/10.1158/2159-8290.c.6547820.v1