Zobrazeno 1 - 10
of 754
pro vyhledávání: '"Stephen Hanessian"'
Autor:
Vaishali Jayashankar, Elizabeth Selwan, Sarah E Hancock, Amandine Verlande, Maggie O Goodson, Kazumi H Eckenstein, Giedre Milinkeviciute, Brianna M Hoover, Bin Chen, Angela G Fleischman, Karina S Cramer, Stephen Hanessian, Selma Masri, Nigel Turner, Aimee L Edinger
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 8, Pp 1-23 (2021)
Abstract Ceramide‐induced mitochondrial fission drives high‐fat diet (HFD)‐induced obesity. However, molecules targeting mitochondrial dynamics have shown limited benefits in murine obesity models. Here, we reveal that these compounds are eithe
Externí odkaz:
https://doaj.org/article/4361e064774c4ea893db97027a608704
Publikováno v:
ACS Omega, Vol 5, Iss 42, Pp 27591-27606 (2020)
Externí odkaz:
https://doaj.org/article/2236469ca48441e6a2f6f5ef289bfa52
Autor:
Thilo Focken, Stephen Hanessian
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 10, Iss 1, Pp 1848-1877 (2014)
A review of the synthesis of natural products and bioactive compounds adopting phosphonamide anion technology is presented highlighting the utility of phosphonamide reagents in stereocontrolled bond-forming reactions. Methodologies utilizing phosphon
Externí odkaz:
https://doaj.org/article/4a90e1b3a4444103b6c380b25feec321
Publikováno v:
The Journal of Organic Chemistry. 88:4675-4686
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f6919b836d1a48ee346652223ca91ae
https://doi.org/10.1021/acs.joc.3c00169
https://doi.org/10.1021/acs.joc.3c00169
Autor:
Tamilselvan Rajasekaran, Graeme C. Freestone, Rodrigo Galindo-Murillo, Barbara Lugato, Hans Gaus, Michael T. Migawa, Eric. E. Swayze, Thomas E. Cheatham, Punit P. Seth, Stephen Hanessian
Publikováno v:
The Journal of Organic Chemistry. 88:3599-3614
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34b43ee8621b506c8e97b1ef94a57433
https://doi.org/10.1021/acs.joc.2c02796
https://doi.org/10.1021/acs.joc.2c02796
Autor:
Brendan T Finicle, Kazumi H Eckenstein, Alexey S Revenko, Brooke A Anderson, W Brad Wan, Alison N McCracken, Daniel Gil, David A Fruman, Stephen Hanessian, Punit P Seth, Aimee L Edinger
Publikováno v:
Nucleic Acids Research. 51:1583-1599
Inefficient endosomal escape remains the primary barrier to the broad application of oligonucleotide therapeutics. Liver uptake after systemic administration is sufficiently robust that a therapeutic effect can be achieved but targeting extrahepatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fde1b5fd23940ce7c0ce0235ad04603
https://doi.org/10.1093/nar/gkad023
https://doi.org/10.1093/nar/gkad023
Autor:
Jean-Baptiste Garsi, Balázs Komjáti, Gregorio Cullia, Imre Fejes, Melinda Sipos, Zoltán Sipos, Eszter Fördős, Piroska Markacz, Barbara Balázs, Nathalie Lancelot, Sylvie Berger, Eric Raimbaud, David Brown, Laurent-Michel Vuillard, Laure Haberkorn, Cyprian Cukier, Zoltán Szlávik, Stephen Hanessian
Publikováno v:
ACS medicinal chemistry letters, vol 13, iss 6
ACS Med Chem Lett
ACS Med Chem Lett
[Image: see text] On the basis of the knowledge that the proline-rich hot spot PPPRPP region of P(151)PSNPPPRPP(160), an oligopeptide derived from the cytosolic portion of p22(phox) (p22), binds to the single functional bis-SH3 domain of the regulato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa70b14a5bdfbbdfe94d8e9fe7ef2af
https://doi.org/10.1021/acsmedchemlett.2c00094
https://doi.org/10.1021/acsmedchemlett.2c00094
Autor:
Tamilselvan Rajasekaran, Graeme C. Freestone, Rodrigo Galindo-Murillo, Barbara Lugato, Lorena Rico, Juan C. Salinas, Hans Gaus, Michael T. Migawa, Eric E. Swayze, Thomas E. Cheatham, Stephen Hanessian, Punit P. Seth
Publikováno v:
J Am Chem Soc
Journal of the American Chemical Society, vol 144, iss 4
Journal of the American Chemical Society, vol 144, iss 4
The binding affinity of therapeutic oligonucleotides (ONs) for their cognate RNA is determined by the rates of association (ka) and dissociation (kd). Single-stranded ONs are highly flexible and can adopt multiple conformations in solution, some of w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd9b42e50480f4d847f71a556cb14fdc
https://doi.org/10.1021/jacs.1c12323
https://doi.org/10.1021/jacs.1c12323
Publikováno v:
Organic Chemistry Frontiers. 9:649-659
The catalysis of the Hajos–Parrish reaction bycis- andtrans-4,5-ethano-proline was explored experimentally and computationally with DFT (ωB97X-D and MN15) and DLPNO-CCSD(T).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2c48a94efc70ba76a56d5debb2f83d5
https://doi.org/10.1039/d1qo01688a
https://doi.org/10.1039/d1qo01688a
Publikováno v:
The Journal of Organic Chemistry. 86:17955-17964
We report a computational investigation of two reaction cascades occurring following the Claisen rearrangements of aryl propargyl ethers to the alternate ortho positions in unsymmetrical reactants. Our computations explain how substituents influence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1704811278385006961430fdf2da8989
https://doi.org/10.1021/acs.joc.1c02296
https://doi.org/10.1021/acs.joc.1c02296