Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Stephen H. Wrzesinski"'
Publikováno v:
Orbit (Amsterdam, Netherlands).
Recently, several new therapies have emerged to address locally advanced cutaneous basal cell and squamous cell carcinomas. Given the constraints of the ocular adnexa and orbit, this review was designed to discuss the role of these modalities in this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99860d1043909629a31e6ff70d0fdb81
https://pubmed.ncbi.nlm.nih.gov/36214105
https://pubmed.ncbi.nlm.nih.gov/36214105
Autor:
M. Andrew Monticelli, Raquel Izumi, Jeff P. Sharman, Joseph Roswarski, Jacob F. Collen, Jigar V. Desai, Louis M. Staudt, Michail S. Lionakis, Marissa A. Zarakas, Andre Goy, Michael Roshon, Ahmed Hamdy, Stephen H. Wrzesinski, José Baselga, George E. Wright, Keith M. Rose, Mark Roschewski, Wyndham H. Wilson, Kevin K. Chung
Publikováno v:
Science Immunology
Acalabrutinib targets activated BTK in macrophages and was associated with reduced inflammation and clinical improvement in COVID-19.
Patients with severe COVID-19 have a hyperinflammatory immune response suggestive of macrophage activation. Bru
Patients with severe COVID-19 have a hyperinflammatory immune response suggestive of macrophage activation. Bru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddda9f23da6c6c5a6e0980c7a4c57c62
Publikováno v:
Nature Reviews Immunology. 10:554-567
Transforming growth factor-beta (TGFbeta) is an immunosuppressive cytokine produced by tumour cells and immune cells that can polarize many components of the immune system. This Review covers the effects of TGFbeta on natural killer (NK) cells, dendr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f22168d15a924ce3a690b8b6b8e20bc
https://doi.org/10.1038/nri2808
https://doi.org/10.1038/nri2808
Publikováno v:
Clinical Cancer Research. 13:5262-5270
Immune homeostasis is a delicate balance between the immune defense against foreign pathogens and suppression of the immune system to maintain self-tolerance and prevent autoimmune disease. Maintenance of this balance involves several crucial network
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75cb71d6e6644dead7a65f1971587232
https://doi.org/10.1158/1078-0432.ccr-07-1157
https://doi.org/10.1158/1078-0432.ccr-07-1157
Autor:
Lorna K. Mayo, Konstantin H. Dragnev, Stephen H. Wrzesinski, Jonathan D. Marotti, Brent T. Harris
Publikováno v:
Journal of Neuro-Oncology. 76:277-281
A 59-year-old male was transferred to our facility after initial workup for left eye blindness revealed multiple brain lesions. The patient presented with scant pedunculated skin lesions on his neck and arms, axillary freckling and bilateral subcutan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96c3606a9ff538905ce1bde8788dd4c5
https://doi.org/10.1007/s11060-005-6588-4
https://doi.org/10.1007/s11060-005-6588-4
Publikováno v:
Experimental Hematology & Oncology
Among the dendritic cell (DC) subsets, plasmacytoid DC's (pDC) are thought to be important in the generation of both antiviral and antitumor responses. While pDC may be useful in developing dendritic cell-based tumor vaccines, the low frequency of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db14218060fe0b4a0b6eb670125b6592
https://doi.org/10.1186/2162-3619-2-8
https://doi.org/10.1186/2162-3619-2-8
Autor:
Michael Look, David Gonzalez, Ann Habermann, Tarek M. Fahmy, Jason Park, Steven M. Jay, Stacey L. Demento, Stephen H. Wrzesinski, Ragy Ragheb, Jason M. Criscione, Atu Agawu, Eric Stern, Richard A. Flavell, Paula Licona Limon, Anthony F. Ferrandino
The tumour microenvironment thwarts conventional immunotherapy through multiple immunologic mechanisms, such as the secretion of the transforming growth factor-β (TGF-β), which stunts local tumour immune responses. Therefore, high doses of interleu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::715a4ca45d5dcf38bfd5cbc634720230
https://europepmc.org/articles/PMC3601683/
https://europepmc.org/articles/PMC3601683/
Publikováno v:
Clinics in liver disease. 15(2)
Many potential systemic therapies are being investigated for the treatment of hepatocellular carcinoma (HCC). The incidence of this malignancy is rising sharply and the vast majority of patients present at advanced stages. Although the earlier dismal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0b0f65e18b251a8f00f0d59167377c9
https://pubmed.ncbi.nlm.nih.gov/21689622
https://pubmed.ncbi.nlm.nih.gov/21689622
Autor:
Mark Kneteman, Andrew Mason, Don Graham, Min Chen, Suzanna Gilady, Guangzhi Zhang, Richard A. Flavell, Michael Trauner, Shawn T. Wasilenko, Stephen H. Wrzesinski, Mark G. Swain, Chelsea McDougall, Lok Man J. Law, Benchamas Subsin
Publikováno v:
Journal of hepatology. 55(4)
Background & Aims A human betaretrovirus resembling the mouse mammary tumor virus (MMTV) has been characterized in primary biliary cirrhosis (PBC) and associated with aberrant pyruvate dehydrogenase complex (PDC)–E2-like expression. As MMTV is prev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::826ed71797596231ce8d1e8c9ce58d77
https://pubmed.ncbi.nlm.nih.gov/21334408
https://pubmed.ncbi.nlm.nih.gov/21334408
Autor:
Peter M. Rabinovich, Stephen H. Wrzesinski, Marina E. Komarovskaya, Alexander Karpikov, Jonathan Alderman, Nai-Kong Cheung, Erkut Bahceci, Hongfen Guo, Sherman M. Weissman, Tulin Budak-Alpdogan, Richard A. Flavell
Publikováno v:
Human gene therapy. 20(1)
mRNA transfection is a useful approach for temporal cell reprogramming with minimal risk of transgene-mediated mutagenesis. We applied this to redirect lymphocyte cytotoxicity toward malignant cells. Using the chimeric immune receptor (CIR) construct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56e6e95f70ba33b384ef8b1ea4271862
https://pubmed.ncbi.nlm.nih.gov/19025415
https://pubmed.ncbi.nlm.nih.gov/19025415