Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Stephen H. Clarke"'
Publikováno v:
Journal of Extracellular Vesicles, Vol 8, Iss 1 (2019)
Extracellular vesicles (EVs) have great potential as a source for clinically relevant biomarkers since they can be readily isolated from biofluids and carry microRNA (miRNA), mRNA, and proteins that can reflect disease status. However, the biological
Externí odkaz:
https://doaj.org/article/3df6fdf85a7049a0899e8dc041aa3fd6
Autor:
Xiangdong Lu, Chi-Shuen Chu, Terry Fang, Violeta Rayon-Estrada, Fang Fang, Alina Patke, Ye Qian, Stephen H. Clarke, Ari M. Melnick, Yi Zhang, F. Nina Papavasiliou, Robert G. Roeder
Publikováno v:
Cell Reports, Vol 28, Iss 2, Pp 472-485.e5 (2019)
Summary: The NuRD complex contains both chromatin remodeling and histone deacetylase activities. Mice lacking the MTA2 subunit of NuRD show developmental defects in pro-B, pre-B, immature B, and marginal zone B cells, and abnormal germinal center B c
Externí odkaz:
https://doaj.org/article/717fe5138aec4299ab71faf0f9b1d0a2
Autor:
Amanda B. Keener, Sun Ah Kang, Lance T. Thurlow, Kenji M. Cunnion, Roland Tisch, Nicholas A. Spidale, Anthony R. Richardson, Stephen H. Clarke, Barbara J. Vilen
Publikováno v:
The Journal of Immunology. 198:1263-1273
Infection with Staphylococcus aureus does not induce long-lived protective immunity for reasons that are not completely understood. Human and murine vaccine studies support a role for Abs in protecting against recurring infections, but S. aureus modu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1280b3e0b497537828482ae3d4934fc
https://doi.org/10.4049/jimmunol.1600093
https://doi.org/10.4049/jimmunol.1600093
Publikováno v:
Journal of Extracellular Vesicles
Journal of Extracellular Vesicles, Vol 8, Iss 1 (2019)
Journal of Extracellular Vesicles, Vol 8, Iss 1 (2019)
Extracellular vesicles (EVs) have great potential as a source for clinically relevant biomarkers since they can be readily isolated from biofluids and carry microRNA (miRNA), mRNA, and proteins that can reflect disease status. However, the biological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ffd3cfa30aa9dde7cba4adf15c51de1
http://europepmc.org/articles/PMC6844434
http://europepmc.org/articles/PMC6844434
Autor:
M. Mozaffari, Céline Mamie, L Wang, Stephen H. Clarke, Martin Hausmann, Bruce Weder, Bradford L. McRae, Luc Biedermann, C. L. Graff, Anja Moncsek, Gerhard Rogler, Pedro A. Ruiz
Summary In inflammatory bowel disease (IBD), inflammation is sustained by an exaggerated response of lymphocytes. This results from enhanced expression of anti-apoptotic B cell lymphoma (BCL-2) and BCL-XL associated with a diminished turnover. Azathi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a011318881ca4ca5ce3cc4dda3713f7e
https://www.zora.uzh.ch/id/eprint/158503/
https://www.zora.uzh.ch/id/eprint/158503/
Autor:
Robert G. Roeder, Alina Patke, Ye Qian, Terry Fang, Chi-Shuen Chu, Xiangdong Lu, Stephen H. Clarke, Fang Fang, Ari Melnick, Yi Zhang, F. Nina Papavasiliou, Violeta Rayon-Estrada
Publikováno v:
Cell reports
Cell Reports, Vol 28, Iss 2, Pp 472-485.e5 (2019)
Cell Reports, Vol 28, Iss 2, Pp 472-485.e5 (2019)
SUMMARY The NuRD complex contains both chromatin remodeling and histone deacetylase activities. Mice lacking the MTA2 subunit of NuRD show developmental defects in pro-B, pre-B, immature B, and marginal zone B cells, and abnormal germinal center B ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8a88efe2a5b70c3712297fca1562cc5
https://pubmed.ncbi.nlm.nih.gov/31291582
https://pubmed.ncbi.nlm.nih.gov/31291582
Autor:
Céline Mamie, Bradford L. McRae, Gerhard Rogler, Pedro A. Ruiz, Stephen H. Clarke, Martin Hausmann, Bruce Weder
Publikováno v:
Web of Science
Background Fibrosis in patients with Crohn's disease (CD) results from an imbalance toward excessive fibrous tissue formation driven by fibroblasts. Activation of fibroblasts is linked to the B-cell lymphoma 2 (BCL2) family, which is involved in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2338fa3d7180bda1d160234ecde379ca
https://pubmed.ncbi.nlm.nih.gov/29796658
https://pubmed.ncbi.nlm.nih.gov/29796658
Autor:
Yuri Fedoriw, Stephen H. Clarke, Barbara J. Vilen, John L. Schmitz, Jennifer L. Rogers, SunAh Kang, Andrew J. Monteith, Marilyn Diaz, Chuancang Jiang, Young K. Truong, Teresa K. Tarrant
Apoptotic debris, autoantibody, and IgG–immune complexes (ICs) have long been implicated in the inflammation associated with systemic lupus erythematosus (SLE); however, it remains unclear whether they initiate immune-mediated events that promote d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50d5188d0e261aeb90fa30ec9ccb4621
Autor:
Stephen H. Clarke
Publikováno v:
Immunologic Research. 41:203-216
Autoimmunity is a serious health problem and understanding the maintenance and loss of tolerance to self-antigens are key issues in developing new therapeutic strategies to treat these diseases. Despite considerable progress toward understanding B ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c148bcc0e9ed62b5baa85da346a48ec
https://doi.org/10.1007/s12026-008-8023-3
https://doi.org/10.1007/s12026-008-8023-3
Autor:
Jason K. Whitmire, Robert J. Benschop, Alfredo Caro-Maldonado, SunAh Kang, Barbara J. Vilen, Glenn K. Matsushima, Stephen H. Clarke, Jeffrey C. Rathmell, Shannon Z. Jones, Amanda B. Keener
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 196(1)
Memory B cell responses are vital for protection against infections but must also be regulated to prevent autoimmunity. Cognate T cell help, somatic hypermutation, and affinity maturation within germinal centers (GCs) are required for high-affinity m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d0a3df69b063aed46cca640e71dd236
https://pubmed.ncbi.nlm.nih.gov/26621863
https://pubmed.ncbi.nlm.nih.gov/26621863