Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Stephen H Pasternak"'
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0161445 (2016)
The amyloid hypothesis posits that the production of β-amyloid (Aβ) aggregates leads to neurodegeneration and cognitive decline associated with AD. Aβ is produced by sequential cleavage of the amyloid precursor protein (APP) by β- and γ-secretas
Externí odkaz:
https://doaj.org/article/9e36832fd9184f6c873e5c3e673f2c6c
Autor:
Fabiana A Caetano, Brennan S Dirk, Joshua H K Tam, P Craig Cavanagh, Maria Goiko, Stephen S G Ferguson, Stephen H Pasternak, Jimmy D Dikeakos, John R de Bruyn, Bryan Heit
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 12, p e1004634 (2015)
Our current understanding of the molecular mechanisms which regulate cellular processes such as vesicular trafficking has been enabled by conventional biochemical and microscopy techniques. However, these methods often obscure the heterogeneity of th
Externí odkaz:
https://doaj.org/article/4f80efcfac3d4cf9ba07173424149539
Autor:
Chloe A. Stewart, Derek G. V. Mitchell, Penny A. MacDonald, Stephen H. Pasternak, Paul F. Tremblay, Elizabeth C. Finger
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Guilt is a negative emotion elicited by realizing one has caused actual or perceived harm to another person. One of guilt’s primary functions is to signal that one is aware of the harm that was caused and regrets it, an indication that the
Externí odkaz:
https://doaj.org/article/f27f3b49f7e146d5ab10ba71bde3bfed
Publikováno v:
Heliyon, Vol 10, Iss 10, Pp e31077- (2024)
The overproduction of the toxic peptide amyloid-beta (Aβ) generated from the cleavage of amyloid precursor protein (APP) is proposed to be a critical event in the development of Alzheimer's disease. Evidence suggests that the cleavage of APP occurs
Externí odkaz:
https://doaj.org/article/f45a7b44a2e048a0844864d2608eaa77
Autor:
Allison A. Dilliott, Kristina K. Zhang, Jian Wang, Agessandro Abrahao, Malcolm A. Binns, Sandra E. Black, Michael Borrie, Dar Dowlatshahi, Elizabeth Finger, Corinne E. Fischer, Andrew Frank, Morris Freedman, David Grimes, Ayman Hassan, Mandar Jog, Sanjeev Kumar, Anthony E. Lang, Jennifer Mandzia, Mario Masellis, Stephen H. Pasternak, Bruce G. Pollock, Tarek K. Rajji, Ekaterina Rogaeva, Demetrios J. Sahlas, Gustavo Saposnik, Christine Sato, Dallas Seitz, Christen Shoesmith, Thomas D. L. Steeves, Richard H. Swartz, Brian Tan, David F. Tang‐Wai, Maria C. Tartaglia, John Turnbull, Lorne Zinman, ONDRI Investigators, Robert A. Hegele
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 10, Iss 8, Pp n/a-n/a (2022)
Abstract Background Although genetic factors are known to contribute to neurodegenerative disease susceptibility, there remains a large amount of heritability unaccounted for across the diagnoses. Copy number variants (CNVs) contribute to these pheno
Externí odkaz:
https://doaj.org/article/649dad53d67b47c99ebb458bbdb9833e
Autor:
Chloe A. Stewart, Derek G.V. Mitchell, Penny A. MacDonald, Stephen H. Pasternak, Paul F. Tremblay, Elizabeth Finger
Publikováno v:
Cognitive, Affective, & Behavioral Neuroscience.
Guilt is a negative emotion, elicited by realizing one has caused actual or perceived harm to another person. Anecdotally, guilt often is described as a visceral and physical experience. However, while the way that the body responds to and contribute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a5253abd8534484b0dd1759417859aa
https://doi.org/10.3758/s13415-023-01079-3
https://doi.org/10.3758/s13415-023-01079-3
Autor:
Kelly M, Sunderland, Derek, Beaton, Stephen R, Arnott, Peter, Kleinstiver, Donna, Kwan, Jane M, Lawrence-Dewar, Joel, Ramirez, Brian, Tan, Robert, Bartha, Sandra E, Black, Michael, Borrie, Donald, Brien, Leanne K, Casaubon, Brian C, Coe, Benjamin, Cornish, Allison A, Dilliott, Dar, Dowlatshahi, Elizabeth, Finger, Corinne, Fischer, Andrew, Frank, Julia, Fraser, Morris, Freedman, Barry, Greenberg, David A, Grimes, Ayman, Hassan, Wendy, Hatch, Robert A, Hegele, Christopher, Hudson, Mandar, Jog, Sanjeev, Kumar, Anthony, Lang, Brian, Levine, Wendy, Lou, Jennifer, Mandzia, Connie, Marras, William, McIlroy, Manuel, Montero-Odasso, David G, Munoz, Douglas P, Munoz, Joseph B, Orange, David S, Park, Stephen H, Pasternak, Frederico, Pieruccini-Faria, Tarek K, Rajji, Angela C, Roberts, John F, Robinson, Ekaterina, Rogaeva, Demetrios J, Sahlas, Gustavo, Saposnik, Christopher J M, Scott, Dallas, Seitz, Christen, Shoesmith, Thomas D L, Steeves, Michael J, Strong, Stephen C, Strother, Richard H, Swartz, Sean, Symons, David F, Tang-Wai, Maria Carmela, Tartaglia, Angela K, Troyer, John, Turnbull, Lorne, Zinman, Paula M, McLaughlin, Mario, Masellis, Malcolm A, Binns, Guangyong, Zou
Publikováno v:
Alzheimer's & Dementia. 19:226-243
Understanding synergies between neurodegenerative and cerebrovascular pathologies that modify dementia presentation represents an important knowledge gap.This multi-site, longitudinal, observational cohort study recruited participants across prevalen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b08e5d9a90df7418ec42065cd1f73856
https://doi.org/10.1002/alz.12632
https://doi.org/10.1002/alz.12632
Autor:
Lucas M Crawford‐Holland, Jennifer S. Rabin, Luis R Fornazzari, Tom A. Schweizer, Corinne E. Fischer, David G. Munoz, Sanjeev Kumar, Sandra E. Black, Morris Freedman, Michael Borrie, Andrew R Frank, Stephen H Pasternak, Bruce G. Pollock, Tarek K. Rajji, Dallas Seitz, David F. Tang‐Wai, Carmela Tartaglia, Donna Kwan, Brian Tan
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1669676744de4eb59fc1adc7f0ee4ac
https://doi.org/10.1002/alz.068722
https://doi.org/10.1002/alz.068722
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0f5271c68b1de13ca4ce9f8b7719e39
https://doi.org/10.1002/alz.067978
https://doi.org/10.1002/alz.067978