Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Stephen G. Zimmer"'
Autor:
Stephen G. Zimmer
Publikováno v:
The Review of Austrian Economics.
What role does education play in economic growth? Conventional wisdom and macroeconomic theories posit that as a nation becomes more educated, they become wealthier. The basic argument says a more educated populace is more productive (i.e. the qualit
Autor:
Amy L. Cooper, Pamela S. Lancaster, Stephen G. Zimmer, John R. van Nagell, Susan C. Modesitt, Victoria L. Greenberg
Publikováno v:
Gynecologic Oncology. 104:596-601
Objective. To determine effects of suberoylanilide hydroxamic acid (SAHA) with and without paclitaxel in ovarian cancer cells and a nude mouse model. Methods. Cell viability and apoptosis of ovarian cancer cells (2774) were measured following exposur
Autor:
J. R. Graff, Connie Zimmer, Stephen G. Zimmer, D. L. Tudor, Erwin R. Boghaert, A. De Benedetti, Shung Kai Chan
Publikováno v:
International Journal of Cancer. 60:255-263
Expression of the T24ras oncogene induces malignancy (tumor growth, invasion and metastasis) in cloned rat embryo fibroblasts (CREF T24). In CREF T24, the rate of phosphorylation of eukaryotic translation initiation factor 4E (eIF-4E) is increased, r
Publikováno v:
Oncogene. 24:4851-4860
Initial chemotherapeutic treatment triggers a stress-related response, which can lead to an increase in the expression of survival proteins. In this study we examine whether paclitaxel (PTX) alters the expression and/or phosphorylation of the transla
Autor:
Jeffrey S. Shenberger, Jennifer L. Myers, Aaron Barchowsky, Stephen G. Zimmer, Richard J. Powell
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 288:L442-L449
Hyperoxia is cytotoxic and depresses many cellular metabolic functions including protein synthesis. Translational control is exerted primarily during initiation by two mechanisms: 1) through inhibition of translation initiation complex formation via
Autor:
Jeremy R. Graff, Stephen G. Zimmer
Publikováno v:
Clinical and Experimental Metastasis. 20:265-273
To form metastases, tumors must break from the primary tumor site, invade surrounding tissues, enter and survive within the circulation and ultimately colonize a distal tissue. Each of these steps requires the cooperative function of numerous protein
Publikováno v:
Bioorganic & Medicinal Chemistry. 10:103-110
The synthesis of a novel E-ring modified keto ether analogue of camptothecin and homocamptothecin by the cascade radical annulation route is reported. The analogue, Du1441, is an isomer of homocamptothecin, but includes the alpha-hydroxy carbonyl fun
Autor:
Bin Liu, David M. Kaetzel, Nancy G. Pedigo, Stephen G. Zimmer, Zhenlan Xing, Zengliang Bai, Edith H. Postel, Deqin Ma
Publikováno v:
Journal of Biological Chemistry. 277:1560-1567
The platelet-derived growth factor (PDGF)-A promoter is regulated by a number of GC-rich regulatory elements that possess non-B-form DNA structures. Screening of a HeLa cDNA expression library with the C-rich strand of a PDGF-A silencer sequence (5'-
Autor:
Joseph R, McCorkle, Mary K, Leonard, Susan D, Kraner, Eric M, Blalock, Deqin, Ma, Stephen G, Zimmer, David M, Kaetzel
Publikováno v:
Cancer genomicsproteomics. 11(4)
NME1 is a well-documented metastasis suppressor gene, with suppressor activity demonstrated across a wide spectrum of human cancers including melanoma and carcinomas of the breast, stomach and thyroid. A primary aim of the current study was to identi
Autor:
David Bom, Thomas G. Burke, Robert L. Bevins, J. N. Howe, Stefan Kruszewski, Lori J. Latus, Stephen G. Zimmer, AL Bingcang, Junhong Zhang, Dennis P. Curran
Publikováno v:
Journal of Controlled Release. 74:325-333
The novel silatecan 7-t-butyldimethylsilyl-10-hydroxycamptothecin (DB-67) is 25- to 50-times more lipophilic than camptothecin and readily incorporates into lipid bilayers. Using the method of fluorescence anisotropy titration, we determined that DB-