Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Stephen G. Thein"'
Autor:
John D. Hudson, Richard K. Bogan, Heike Benes, Dan Chen, Thomas Stern, Lawrence Lee, Stephen G. Thein, Morgan Bron, Jed Black, Terri E. Weaver, Christopher L. Drake, James Maynard, James M. Andry, Lawrence P. Carter
Publikováno v:
Annals of the American Thoracic Society
Rationale: Excessive daytime sleepiness in patients with obstructive sleep apnea is associated with substantial burden of illness. Objectives: To assess treatment effects of solriamfetol, a dopamine/norepinephrine reuptake inhibitor, on daily functio
Autor:
Stephen G. Thein, Gleb Filippov, Margaret Moline, Naoki Kubota, M. Kemethofer-Waliczky, N. Rabbee, Mohammad Bsharat, Shobha Dhadda
Publikováno v:
The Journal of Prevention of Alzheimer's Disease. :1-12
BACKGROUND: Irregular sleep-wake rhythm disorder (ISWRD) is a common sleep disorder in individuals with Alzheimer’s disease dementia (AD-D). OBJECTIVES: This exploratory phase 2 proof-of-concept and dose-finding clinical trial evaluated the effects
Autor:
Whitney Chao, Brian Beck, Katie Koborsi, Steven P. Braithwaite, Vicki Klutzaritz, Karoly Nikolich, Jonas Hannestad, Gary Kay, Ashok K. Patel, Stephen G. Thein, Tiffanie Duclos, James Scott, Jeffrey L. Cummings
Publikováno v:
Journal of Alzheimer's disease : JAD. 81(4)
Background: The plasma fraction GRF6019 shows multiple benefits on brain aging in mice, including enhanced cognition, neurogenesis, and synaptic density, as well as reduced neuroinflammation. Objective: To evaluate the safety, tolerability, and preli
Autor:
Mohammad Bsharat, Naoki Kubota, Margaret Moline, Manuel Kemethofer, Stephen G. Thein, Gleb Filippov
Publikováno v:
Alzheimer's & Dementia. 15
Autor:
Paula K. Schweitzer, Russell Rosenberg, Gary K. Zammit, Mark Gotfried, Dan Chen, Lawrence P. Carter, Hao Wang, Yuan Lu, Jed Black, Atul Malhotra, Kingman P. Strohl, Adam Blackman, Charles George, Colin Shapiro, Heike Benes, Ingo Fietze, Geert Mayer, Peter Young, Gert Jan Lammers, Mansoor Ahmed, Akinyemi Ajayi, James Andry, Roy Artal, Bijan Bastani, Richard Bogan, Bruce Corser, Christopher Drake, Helene Emsellem, Milton Erman, Neil Feldman, Nancy Foldvary, John Hudson, Lois Krahn, Daniel Lorch, James Maynard, Emmanuel Mignot, Michael Neeb, Joseph Ojile, Alvin Thomas Perkins, Asim Roy, Pradeep Sahota, R. Bart Sangal, Andrew Schreiber, Paula Schweitzer, Ralph Steele, Thomas Stern, Sarah Stolz, Kingman Strohl, Todd Swick, Todd J. Swick, Stephen G. Thein, Robert Thomas, Michael Thorpy, Terri Weaver, Kerri Wilks, David Winslow, Paul Wylie, Gary Zammit, Phyllis Zee
Publikováno v:
American Journal of Respiratory and Critical Care Medicine
Rationale: Primary treatment of obstructive sleep apnea can be accompanied by a persistence of excessive sleepiness despite adherence. Furthermore, effectiveness of sleep apnea treatment is limited by poor adherence. Currently available pharmacologic
Autor:
Ira J. Goodman, Sharon Cohen, Ian Cohen, Stephen G. Thein, Matthew Bubalo, Fadi Frankul, Sophia Marie Pagtakhan, Caroline C. Smith
Publikováno v:
Alzheimer's & Dementia. 13
Autor:
Clete A. Kushida, Douglas N. Greve, Andrew D. Krystal, Stephen G. Thein, Linda J. Larson-Prior, Sean P.A. Drummond, Michele T. Diaz, Stephen P. Duntley, Ronghua Yang, Robert Thomas
Publikováno v:
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, vol 10, iss 2
Study objectiveTo assess the effect of armodafinil on task-related prefrontal cortex activation using functional magnetic resonance imaging (fMRI) in patients with obstructive sleep apnea (OSA) and excessive sleepiness despite continuous positive air
Autor:
Ira J. Goodman, Mark I. Ryder, Stephen G. Thein, Ursula Haditsch, Mike Detke, Dave Hennings, Leslie J. Holsinger, Shirin Kapur, Steve Dominy, Casey C. Lynch, Florian Ermini, Debasish Raha
Publikováno v:
Alzheimer's & Dementia. 15:P1585-P1585
Autor:
Ronald W. Barrett, Philip M. Becker, Daniel M. Canafax, A. Thomas Perkins, Arthur S. Walters, Clete A. Kushida, Thomas Roth, Stephen G. Thein
Publikováno v:
Sleep. 32:159-168
TWO TO 3 PERCENT OF THE US POPULATION EXPERIENCE CLINICALLY RELEVANT SYMPTOMS OF PRIMARY RESTLESS LEGS SYNDROME (RLS) SEVERE enough to warrant treatment.1–3 Patients with RLS report difficulty falling asleep and exhibit abnormal sleep architecture,
Publikováno v:
Innovations in clinical neuroscience. 9(2)
First, parallels are drawn between the conduct of clinical trials and a few events in history that share a management style known as "top-down" management or a hierarchal decision-making process. The author suggests that this process isolates investi