Zobrazeno 1 - 10
of 178
pro vyhledávání: '"Stephen G. Holt"'
Publikováno v:
Kidney International Reports, Vol 5, Iss 9, Pp 1432-1447 (2020)
Introduction: Calciprotein particles (CPPs) are potentially modifiable mediators of phosphate toxicity in patients with kidney disease. We compared the effects of calcium carbonate (CC) and the non–calcium-based phosphate binder sevelamer on CPP le
Externí odkaz:
https://doaj.org/article/e094b24163e14763bd5938c8d7c26e1c
Autor:
Adam L. Flavell, Robert O. Fullinfaw, Edward R. Smith, Stephen G. Holt, Moira J. Finlay, Thomas D. Barbour
Publikováno v:
BMC Nephrology, Vol 21, Iss 1, Pp 1-7 (2020)
Abstract Background Cryoglobulins are cold-precipitable immunoglobulins that may cause systemic vasculitis including cryoglobulinaemic glomerulonephritis (CGN). Type 1 cryoglobulins consist of isolated monoclonal immunoglobulin (mIg), whereas mixed c
Externí odkaz:
https://doaj.org/article/a651ff7f152649aaa17ad711cb7ecf7c
Autor:
Irene Ruderman, Tim D. Hewitson, Edward R. Smith, Stephen G. Holt, Belinda Wigg, Nigel D. Toussaint
Publikováno v:
BMC Nephrology, Vol 21, Iss 1, Pp 1-10 (2020)
Abstract Background Vascular calcification (VC) is well described in large- and medium-sized vessels in patients with chronic kidney disease (CKD), especially in those with end-stage kidney disease (ESKD) on dialysis. Medial calcification is particul
Externí odkaz:
https://doaj.org/article/3641f2a27c5e4245bcda62cae4b8fd41
Publikováno v:
BMC Nephrology, Vol 19, Iss 1, Pp 1-12 (2018)
Abstract Background The calcimimetic agent cinacalcet is effective for the management of secondary hyperparathyroidism (SHPT) in dialysis patients. Changes to reimbursement of cinacalcet in Australia provided an opportunity to assess effects of medic
Externí odkaz:
https://doaj.org/article/677d8c90f8b6425c873cc0285daae812
Autor:
Edward R. Smith, Tim D. Hewitson, Michael M. X. Cai, Parisa Aghagolzadeh, Matthias Bachtler, Andreas Pasch, Stephen G. Holt
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)
Abstract Calciprotein particles, nanoscale aggregates of insoluble mineral and binding proteins, have emerged as potential mediators of phosphate toxicity in patients with Chronic Kidney Disease. Although existing immunochemical methods for their det
Externí odkaz:
https://doaj.org/article/4660db06f2274211a15dd40111002799
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract In kidney disease, higher circulating levels of the mineral-regulating hormone fibroblast growth factor (FGF)-23 are predictive of disease progression but direct pathogenic effects on the kidney are unknown. We sought evidence of local renal
Externí odkaz:
https://doaj.org/article/aa93e77520674b35bece2d357cb8d726
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Although the kidney has capacity to repair after mild injury, ongoing or severe damage results in scarring (fibrosis) and an associated progressive loss of kidney function. However, despite its universal significance, evidence highlights a population
Externí odkaz:
https://doaj.org/article/00d6a88a4cd04dfcbaaa30146c8ea0bd
Autor:
Timothy D. Hewitson, Stephen G. Holt, Sven-Jean Tan, Belinda Wigg, Chrishan S. Samuel, Edward R. Smith
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Introduction: Epigenetic regulation of fibrogenesis through post-translational histone modifications (marks) may be a key determinant of progression in renal disease. In this study, we examined the distribution and acquisition of histone 3 Lysine 9 (
Externí odkaz:
https://doaj.org/article/f3e387d9a988453aa37574fcdcee8015
Publikováno v:
Saudi Journal of Kidney Diseases and Transplantation, Vol 33, Iss 3, Pp 413-417 (2022)
Some epidemiological data have implicated blood groups in susceptibility to coronavirus disease 2019 (COVID-19) infection. We were interested to see if there was any apparent effect of different ABO blood groups on susceptibility to COVID-19 infectio
Externí odkaz:
https://doaj.org/article/a3b2828cc2684b24ba7791f9ef0d5cfd
Autor:
Ursula Thiem, Tim D Hewitson, Nigel D Toussaint, Stephen G Holt, Maria C Haller, Andreas Pasch, Daniel Cejka, Edward R Smith
Publikováno v:
Nephrology Dialysis Transplantation. 38:1282-1296
Background Calciprotein particles (CPPs), colloidal mineral-protein nanoparticles, have emerged as potential mediators of phosphate toxicity in dialysis patients, with putative links to vascular calcification, endothelial dysfunction and inflammation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9995193d6cd763d57a772a4b8fa09df1
https://doi.org/10.1093/ndt/gfac271
https://doi.org/10.1093/ndt/gfac271