Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Stephen G. Farmer"'
Autor:
Roland Buhl, Stephen G. Farmer
Publikováno v:
Proceedings of the American Thoracic Society. 2:83-93
Current therapy for chronic obstructive pulmonary disease (COPD) fails to alter its relentless progression. This remains a significant challenge and unmet need. A recent advance is the demonstration that treatment with a fixed dose of an inhaled cort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::140bd7e0643a0b654bfddee2d61f41e1
https://doi.org/10.1513/pats.200411-054sf
https://doi.org/10.1513/pats.200411-054sf
Autor:
Stephen G. Farmer, Stephen I. Rennard
Publikováno v:
Proceedings of the American Thoracic Society. 1:88-92
Exacerbations, characterized by an increase in patients' symptoms above baseline, are characteristic of both chronic obstructive pulmonary disease (COPD) and asthma. Prevention of exacerbations and their expedient treatment are major goals for reduci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4359ed7730e83bd5a84c2f51213ac45
https://doi.org/10.1513/pats.2306026
https://doi.org/10.1513/pats.2306026
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 166:954-960
To test whether a serine elastase inhibitor could prevent or reduce emphysema, we exposed guinea pigs to cigarette smoke acutely, or daily for 6 months, and treated some animals with the neutrophil elastase inhibitor ZD0892. Acute smoke exposure incr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fc16047800adbe16331adcf23ccbe6e
https://doi.org/10.1164/rccm.200202-098oc
https://doi.org/10.1164/rccm.200202-098oc
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 73:805-811
A series of competitive, nonpeptide bradykinin receptor antagonists based on an α-amino acid scaffold have been developed and biologically characterized. The lead compound in the series, WIN 64338, demonstrates competitive inhibition of bradykinin-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce413a213753e54317d87ab812be3c06
https://doi.org/10.1139/y95-109
https://doi.org/10.1139/y95-109
Autor:
Mark A. DeSiato, Stephen G. Farmer
Publikováno v:
British Journal of Pharmacology. 112:461-464
1. We examined the effects of phosphonium, [[4-[[2- [[bis(cyclohexylamino)methylene]amino]-3-(2-naphthalenyl) 1-oxopropyl]amino]-phenyl]-tributyl, chloride, monohydrochloride (WIN 64338), a novel, nonpeptide bradykinin B2 receptor antagonist, on brad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e894e64d217070fe7a5d6865ff2e53c
https://doi.org/10.1111/j.1476-5381.1994.tb13095.x
https://doi.org/10.1111/j.1476-5381.1994.tb13095.x
Autor:
Stephen G. Farmer, Stephen I. Rennard
Publikováno v:
Chest. 121:113S-115S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3d850a5d6554fa39831626ee80ba07d
https://doi.org/10.1378/chest.121.5_suppl.113s
https://doi.org/10.1378/chest.121.5_suppl.113s
Autor:
Stephen G. Farmer
Publikováno v:
Pharmacology & Toxicology. 72:3-10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c58cf00303ff75c6dc3ec953ead00f4
https://doi.org/10.1111/j.1600-0773.1993.tb01691.x
https://doi.org/10.1111/j.1600-0773.1993.tb01691.x
Publikováno v:
British Journal of Pharmacology. 107:653-659
1 We examined effects of bradykinin (BK) receptor antagonists on airway hyperresponsiveness and eosinophilia in sensitized guinea-pigs that had been administered single, as well as repeated (chronic) challenges with inhaled ovalbumin. In addition, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::197314be8b5261e3322df08f3e0d4726
https://doi.org/10.1111/j.1476-5381.1992.tb14502.x
https://doi.org/10.1111/j.1476-5381.1992.tb14502.x
Autor:
Ronald M. Burch, Stephen G. Farmer
Publikováno v:
Annual Review of Pharmacology and Toxicology. 32:511-536
Bradykinin (BK; Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg) is a potent in flammatory peptide whose generation in tissues and body fluids elicits numer ous responses including vasodilation, edema, smooth muscle spasm, as well as pain and hyperalgesia vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a523057c18398a143959d423579ce99
https://doi.org/10.1146/annurev.pa.32.040192.002455
https://doi.org/10.1146/annurev.pa.32.040192.002455
Autor:
Ashfaq Ahmed, William M. Abraham, Ronald M. Burch, Stephen G. Farmer, Alejandro Cortes, M. W. Sielczak
Publikováno v:
American Review of Respiratory Disease. 143:787-796
We assessed the role of bradykinin (BK) in allergen-induced early and late bronchial responses, airway inflammation, mediator release, and antigen-induced airway hyperresponsiveness in allergic sheep by studying the effects of the BK B2 receptor anta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6dd370663a805cec1fa7ce0e6c461b9
https://doi.org/10.1164/ajrccm/143.4_pt_1.787
https://doi.org/10.1164/ajrccm/143.4_pt_1.787