Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Stephen G. Dann"'
Autor:
Shunqiang Li, Donald P. McDonnell, John D. Norris, Jin-Ping Lai, Robert Crowder, Jieya Shao, Elizabeth Griffin, Tina Primeau, Kim T. Arndt, Stephen G. Dann, Todd VanArsdale, Koleen Eisele, Holly M. Alley, Matthew J. Ellis, Suzanne E. Wardell
Supplemental figure 3: SERDs and palbociclib inhibit breast cancer cell proliferation by independent mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::913466b83847b02760d8832503645b8d
https://doi.org/10.1158/1078-0432.22454691.v1
https://doi.org/10.1158/1078-0432.22454691.v1
Autor:
Shunqiang Li, Donald P. McDonnell, John D. Norris, Jin-Ping Lai, Robert Crowder, Jieya Shao, Elizabeth Griffin, Tina Primeau, Kim T. Arndt, Stephen G. Dann, Todd VanArsdale, Koleen Eisele, Holly M. Alley, Matthew J. Ellis, Suzanne E. Wardell
Supplemental figure 4: Evaluation of pharmacodynamics endpoints confirms on target activity of SERDs and palbociclib, resulting in sustained inhibition of tumors receiving both treatments
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ee29c5e6c07b5a865bf126f1bef796e
https://doi.org/10.1158/1078-0432.22454688
https://doi.org/10.1158/1078-0432.22454688
Autor:
Shunqiang Li, Donald P. McDonnell, John D. Norris, Jin-Ping Lai, Robert Crowder, Jieya Shao, Elizabeth Griffin, Tina Primeau, Kim T. Arndt, Stephen G. Dann, Todd VanArsdale, Koleen Eisele, Holly M. Alley, Matthew J. Ellis, Suzanne E. Wardell
Supplemental figure 1: SERDs and SERMs differ in their ability to inhibit ER-dependent stimulation of breast cancer cell proliferation by growth factors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45421649f6c61cc430618d3b84ec6afd
https://doi.org/10.1158/1078-0432.22454700
https://doi.org/10.1158/1078-0432.22454700
Autor:
Shunqiang Li, Donald P. McDonnell, John D. Norris, Jin-Ping Lai, Robert Crowder, Jieya Shao, Elizabeth Griffin, Tina Primeau, Kim T. Arndt, Stephen G. Dann, Todd VanArsdale, Koleen Eisele, Holly M. Alley, Matthew J. Ellis, Suzanne E. Wardell
Supplemental figure 2: SERDs inhibit the constitutive activity of the clinically relevant Y537N,D538G ESR1 double mutant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53e5398bfcdac49fc14ce14291926781
https://doi.org/10.1158/1078-0432.22454697.v1
https://doi.org/10.1158/1078-0432.22454697.v1
Autor:
Shunqiang Li, Donald P. McDonnell, John D. Norris, Jin-Ping Lai, Robert Crowder, Jieya Shao, Elizabeth Griffin, Tina Primeau, Kim T. Arndt, Stephen G. Dann, Todd VanArsdale, Koleen Eisele, Holly M. Alley, Matthew J. Ellis, Suzanne E. Wardell
Supplemental figure 5: IHC analysis of treated PDX tumors indicated on-target activity of bazedoxifene and palbociclib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::741a8d0744eed5814f3385c071daffe5
https://doi.org/10.1158/1078-0432.22454685
https://doi.org/10.1158/1078-0432.22454685
Autor:
Daniel Muñoz‐Espín, Miguel Rovira, Irene Galiana, Cristina Giménez, Beatriz Lozano‐Torres, Marta Paez‐Ribes, Susana Llanos, Selim Chaib, Maribel Muñoz‐Martín, Alvaro C Ucero, Guillermo Garaulet, Francisca Mulero, Stephen G Dann, Todd VanArsdale, David J Shields, Andrea Bernardos, José Ramón Murguía, Ramón Martínez‐Máñez, Manuel Serrano
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 9, Pp n/a-n/a (2018)
Abstract Senescent cells accumulate in multiple aging‐associated diseases, and eliminating these cells has recently emerged as a promising therapeutic approach. Here, we take advantage of the high lysosomal β‐galactosidase activity of senescent
Externí odkaz:
https://doaj.org/article/d67df62499c14123a2c81e830cc433e4
Autor:
George Thomas, Stephen G. Dann
Publikováno v:
FEBS Letters. 580:2821-2829
The target of rapamycin (TOR) is an ancient effector of cell growth that integrates signals from growth factors and nutrients. Two downstream effectors of mammalian TOR, the translational components S6K1 and 4EBP1, are commonly used as reporters of m
Degeneration and regeneration of ultraviolet cone photoreceptors during development in rainbow trout
Publikováno v:
The Journal of Comparative Neurology. 499:702-715
Ultraviolet-sensitive (UVS) cones disappear from the retina of salmonid fishes during a metamorphosis that prepares them for deeper/marine waters. UVS cones subsequently reappear in the retina near sexual maturation and the return migration to natal
Autor:
Manel Joaquin, So Young Kim, Marta Roccio, Jonathan M. Backer, Fried J. T. Zwartkruis, Francois Natt, Johannes L. Bos, Takahiro Nobukuni, George Thomas, Stephen G. Dann, Pawan Gulati, Maya P. Byfield
Publikováno v:
Proceedings of the National Academy of Sciences. 102:14238-14243
During the evolution of metazoans and the rise of systemic hormonal regulation, the insulin-controlled class 1 phosphatidylinositol 3OH-kinase (PI3K) pathway was merged with the primordial amino acid-driven mammalian target of rapamycin (mTOR) pathwa
Publikováno v:
Trends in molecular medicine. 13(6)
Recent studies demonstrate that the mammalian target of rapamycin (mTOR) and its effector, S6 kinase 1 (S6K1), lie at the crossroads of a nutrient–hormonal signaling network that is involved in specific pathological responses, including obesity, di