Zobrazeno 1 - 10
of 771
pro vyhledávání: '"Stephen G Davies"'
Autor:
Areej Abuhammad, Elizabeth Fullam, Edward D Lowe, David Staunton, Akane Kawamura, Isaac M Westwood, Sanjib Bhakta, Alun Christopher Garner, David L Wilson, Peter T Seden, Stephen G Davies, Angela J Russell, Elspeth F Garman, Edith Sim
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52790 (2012)
Latent M. tuberculosis infection presents one of the major obstacles in the global eradication of tuberculosis (TB). Cholesterol plays a critical role in the persistence of M. tuberculosis within the macrophage during latent infection. Catabolism of
Externí odkaz:
https://doaj.org/article/98aa6a8b02cc47b2b32db13289c90ae5
Autor:
Laia Josa-Culleré, Thomas J. Cogswell, Irene Georgiou, Morgan Jay-Smith, Thomas R. Jackson, Carole J. R. Bataille, Stephen G. Davies, Paresh Vyas, Thomas A. Milne, Graham M. Wynne, Angela J. Russell
Publikováno v:
Molecules, Vol 26, Iss 21, p 6648 (2021)
Acute myeloid leukemia (AML) is the most aggressive type of blood cancer, and there is a continued need for new treatments that are well tolerated and improve long-term survival rates in patients. Induction of differentiation has emerged as a promisi
Externí odkaz:
https://doaj.org/article/371c3b38b9e44be49d8dc114324e28ce
Publikováno v:
Journal of Natural Products. 85:306-312
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::791a46d1b8046afba5d4d624282935bd
https://doi.org/10.1021/acs.jnatprod.1c00847
https://doi.org/10.1021/acs.jnatprod.1c00847
Autor:
David Reza, Rosalino Balo, Jose M. Otero, Ai M. Fletcher, Rebeca García-Fandino, Victor M. Sanchez-Pedregal, Stephen G. Davies, Ramon J. Estevez, Juan C. Estevez
We describe the synthesis of trihydroxylated cyclohexane β-amino acids from (–)-shikimic acid, in their cis and trans configuration, and the incorporation of the trans isomer into a trans-2-aminocyclohexanecarboxylic acid peptide chain. Subsequent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::325ef2db0e5f65058856a31c77d0ff75
https://doi.org/10.26434/chemrxiv-2022-zdb5j
https://doi.org/10.26434/chemrxiv-2022-zdb5j
Autor:
Thomas A. Milne, Graham Trevitt, Stephen G. Davies, Douzi Zhang, Thomas R. Jackson, Angela J. Russell, Katrina S. Madden, Laia Josa-Culleré, Paresh Vyas, Graham Michael Wynne, Tom S. Carter, Thomas J. Cogswell
Publikováno v:
Journal of Medicinal Chemistry. 64:15608-15628
Induction of differentiation is a promising therapeutic strategy against acute myeloid leukemia. However, current differentiation therapies are effective only to specific patient populations. To identify novel differentiation agents with wider effica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::203e8ec83667a61e34f8c6a1755a1032
https://doi.org/10.1021/acs.jmedchem.1c00574
https://doi.org/10.1021/acs.jmedchem.1c00574
Publikováno v:
Journal of natural products. 85(7)
The first asymmetric synthesis of microgrewiapine C, a piperidine alkaloid isolated from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a1c364d00a8d9c9b926519232ea4876
https://pubmed.ncbi.nlm.nih.gov/35771599
https://pubmed.ncbi.nlm.nih.gov/35771599
Autor:
Laia Josa-Culleré, Sébastien R.G. Galan, Thomas J. Cogswell, Thomas R. Jackson, Morgan Jay-Smith, Laura Mola, Christopher R. Greaves, Tom S. Carter, Katrina S. Madden, Sophie Trott, Douzi Zhang, Carole J.R. Bataille, Stephen G. Davies, Paresh Vyas, Thomas A. Milne, Alan Naylor, Graham M. Wynne, Angela J. Russell
Publikováno v:
European Journal of Medicinal Chemistry. :115509
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a62f3e71596eecfc453f94d9f831f19
https://doi.org/10.1016/j.ejmech.2023.115509
https://doi.org/10.1016/j.ejmech.2023.115509
Autor:
Thomas R. Jackson, Aini Vuorinen, Laia Josa-Culleré, Katrina S. Madden, Daniel Conole, Thomas J. Cogswell, Isabel V.L. Wilkinson, Laura M. Kettyle, Douzi Zhang, Alison O’Mahony, Deanne Gracias, Lorna McCall, Robert Westwood, Georg C. Terstappen, Stephen G. Davies, Edward W. Tate, Graham M. Wynne, Paresh Vyas, Angela J. Russell, Thomas A. Milne
Publikováno v:
iScience. 25(8)
Despite much progress in developing better drugs, many patients with acute myeloid leukemia (AML) still die within a year of diagnosis. This is partly because it is difficult to identify therapeutic targets that are effective across multiple AML subt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24feb867bcac4431cb50a113b7ed3e9c
https://pubmed.ncbi.nlm.nih.gov/35992086
https://pubmed.ncbi.nlm.nih.gov/35992086
Autor:
Maria Chatzopoulou, Daniel Conole, Enrico Emer, Jessica A. Rowley, Nicky J. Willis, Sarah E. Squire, Becky Gill, Steve Brough, Francis X. Wilson, Graham M. Wynne, Stephen G. Davies, Kay E. Davies, Angela J. Russell
Publikováno v:
Bioorganicmedicinal chemistry. 69
A therapeutic approach that holds the potential to treat all Duchenne muscular dystrophy (DMD) patient populations is utrophin modulation. Ezutromid, a first generation utrophin modulator which was later found to act via antagonism of the arylhydroca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d099ddf0f405ad71cc7e68625a6c6ce4
https://pubmed.ncbi.nlm.nih.gov/35772287
https://pubmed.ncbi.nlm.nih.gov/35772287
Autor:
Stephen G. Davies, Angela J. Russell, Enrico Emer, Sarah E. Squire, Maria Chatzopoulou, Francis Xavier Wilson, Lee Moir, Anne-Sophie Casagrande, Kay E. Davies, Jessica A. Rowley, Graham Michael Wynne, Cristina Lecci, Shawn Harriman
Publikováno v:
ACS Med Chem Lett
[Image: see text] Utrophin modulation is a disease-modifying therapeutic strategy for Duchenne muscular dystrophy that would be applicable to all patient populations. To improve the suboptimal profile of ezutromid, the first-in-class clinical candida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f034da3591b87b632ce8c2271cfa3f61
https://doi.org/10.1021/acsmedchemlett.0c00405
https://doi.org/10.1021/acsmedchemlett.0c00405