Zobrazeno 1 - 10
of 332
pro vyhledávání: '"Stephen Franks"'
Autor:
Niamh S. Sayers, Priyanka Anujan, Henry N. Yu, Stephen S. Palmer, Jaya Nautiyal, Stephen Franks, Aylin C. Hanyaloglu
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2022)
Follicle-stimulating hormone (FSH) and its G protein-coupled receptor, FSHR, represents a paradigm for receptor signaling systems that activate multiple and complex pathways. Classically, FSHR activates Gαs to increase intracellular levels of cAMP,
Externí odkaz:
https://doaj.org/article/68b2b6b7698f46bb95b942fa91ee3022
Autor:
Adithya Gopinath, Phillip M. Mackie, Leah T. Phan, Rosa Mirabel, Aidan R. Smith, Emily Miller, Stephen Franks, Ohee Syed, Tabish Riaz, Brian K. Law, Nikhil Urs, Habibeh Khoshbouei
Publikováno v:
Cells, Vol 12, Iss 2, p 269 (2023)
The dopamine transporter (DAT) regulates the dimension and duration of dopamine transmission. DAT expression, its trafficking, protein–protein interactions, and its activity are conventionally studied in the CNS and within the context of neurologic
Externí odkaz:
https://doaj.org/article/756b7b44ef334c3081b7b75242c0ed5f
Autor:
Katarzyna Siemienowicz, Michael T. Rae, Fiona Howells, Chloe Anderson, Linda M. Nicol, Stephen Franks, William C. Duncan
Publikováno v:
iScience, Vol 23, Iss 6, Pp 101164- (2020)
Summary: Women with polycystic ovary syndrome (PCOS) are more likely to be obese and have difficulty in losing weight. They demonstrate an obesity-independent deficit in adaptive energy expenditure. We used a clinically realistic preclinical model to
Externí odkaz:
https://doaj.org/article/65b07f3771c544dbb4583db245f77b9c
Obesity and Polycystic Ovary Syndrome: Implications for Pathogenesis and Novel Management Strategies
Publikováno v:
Clinical Medicine Insights: Reproductive Health, Vol 13 (2019)
Polycystic ovary syndrome (PCOS) is a common female condition typified by reproductive, hyperandrogenic, and metabolic features. Polycystic ovary syndrome is a genetic condition, exacerbated by obesity. There is a close link between obesity and PCOS
Externí odkaz:
https://doaj.org/article/0f7d8319a43544168ab71df47efaaef5
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 1, p 243 (2020)
Polycystic ovary syndrome (PCOS) is a common endocrinopathy that is associated with an adverse metabolic profile including reduced postprandial thermogenesis. Although abnormalities in adipose tissue function have been widely reported in women with P
Externí odkaz:
https://doaj.org/article/9f7fad9a12154c94bd2e666a6371371b
Autor:
M. Geoffrey Hayes, Margrit Urbanek, David A. Ehrmann, Loren L. Armstrong, Ji Young Lee, Ryan Sisk, Tugce Karaderi, Thomas M. Barber, Mark I. McCarthy, Stephen Franks, Cecilia M. Lindgren, Corrine K. Welt, Evanthia Diamanti-Kandarakis, Dimitrios Panidis, Mark O. Goodarzi, Ricardo Azziz, Yi Zhang, Roland G. James, Michael Olivier, Ahmed H. Kissebah, Reproductive Medicine Network, Elisabet Stener-Victorin, Richard S. Legro, Andrea Dunaif
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/393f16795f94454595f713a5d9530c29
Autor:
Stephen Franks, Kate Hardy
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2018)
Androgen production by the ovary is an essential requirement for normal cyclical secretion of estradiol but its physiological role extends to important actions on both preantral and antral follicle development, including promotion of granulosa cell p
Externí odkaz:
https://doaj.org/article/c2e4691491ff4482b0562f388f3aa4ec
Autor:
Yvonne V Louwers, Nigel W Rayner, Blanca M Herrera, Lisette Stolk, Christopher J Groves, Thomas M Barber, Andre G Uitterlinden, Stephen Franks, Joop S E Laven, Mark I McCarthy
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87335 (2014)
Polycystic Ovary Syndrome (PCOS) has a strong genetic background and the majority of patients with PCOS have elevated BMI levels. The aim of this study was to determine to which extent BMI-increasing alleles contribute to risk of PCOS when contempora
Externí odkaz:
https://doaj.org/article/a5756eaf1a1d4ee0ba5d8a703de4b54e
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80416 (2013)
Polycystic ovary syndrome (PCOS), characterized by ovarian androgen excess, is the commonest endocrine disorder in women. Obesity increases androgen synthesis, a phenomenon attributed to the accompanying hyperinsulinemia. Our hypothesis was that adip
Externí odkaz:
https://doaj.org/article/c55c704495884acb94b612a0a465e01d
Autor:
M. Geoffrey Hayes, Margrit Urbanek, David A. Ehrmann, Loren L. Armstrong, Ji Young Lee, Ryan Sisk, Tugce Karaderi, Thomas M. Barber, Mark I. McCarthy, Stephen Franks, Cecilia M. Lindgren, Corrine K. Welt, Evanthia Diamanti-Kandarakis, Dimitrios Panidis, Mark O. Goodarzi, Ricardo Azziz, Yi Zhang, Roland G. James, Michael Olivier, Ahmed H. Kissebah, Reproductive Medicine Network, Elisabet Stener-Victorin, Richard S. Legro, Andrea Dunaif
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-1 (2016)
Nature Communications 6: Article number: 7502 (2015); Published: 18 August 2015; Updated: 12 February 2016 In the original version of this Article the genetic locus 8p23.1 was incorrectly referred to as 8p32.1 throughout. For example, in the Abstract
Externí odkaz:
https://doaj.org/article/7b91269778df4eacb9ba97a24129d177