Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Stephen Fienberg"'
Autor:
Vinayak Singh, Anna E. Grzegorzewicz, Stephen Fienberg, Rudolf Müller, Lutete Peguy Khonde, Olalla Sanz, Salvatore Alfonso, Beatriz Urones, Gerard Drewes, Marcus Bantscheff, Sonja Ghidelli-Disse, Thomas R. Ioerger, Bhanupriya Angala, Jiuyu Liu, Richard E. Lee, James C. Sacchettini, Inna V. Krieger, Mary Jackson, Kelly Chibale, Sandeep R. Ghorpade
Publikováno v:
ACS Infectious Diseases. 8:2315-2326
Autor:
Preshendren Govender, Rudolf Müller, Kawaljit Singh, Virsinha Reddy, Charles J. Eyermann, Stephen Fienberg, Sandeep R. Ghorpade, Lizbé Koekemoer, Alissa Myrick, Dirk Schnappinger, Curtis Engelhart, Jaclynn Meshanni, Jo Ann W. Byl, Neil Osheroff, Vinayak Singh, Kelly Chibale, Gregory S. Basarab
Publikováno v:
J Med Chem
This is the accepted manuscript version of the work published in its final form as Govender, P., Müller, R., Singh, K., Reddy, V., Eyermann, C. J., Fienberg, S., Ghorpade, S. R., Koekemoer, L., Myrick, A., Schnappinger, D., Engelhart, C., Meshanni,
Autor:
Vinayak, Singh, Anna E, Grzegorzewicz, Stephen, Fienberg, Rudolf, Müller, Lutete Peguy, Khonde, Olalla, Sanz, Salvatore, Alfonso, Beatriz, Urones, Gerard, Drewes, Marcus, Bantscheff, Sonja, Ghidelli-Disse, Thomas R, Ioerger, Bhanupriya, Angala, Jiuyu, Liu, Richard E, Lee, James C, Sacchettini, Inna V, Krieger, Mary, Jackson, Kelly, Chibale, Sandeep R, Ghorpade
Publikováno v:
ACS infectious diseases. 8(11)
Alternative mode-of-inhibition of clinically validated targets is an effective strategy for circumventing existing clinical drug resistance. Herein, we report 1,3-diarylpyrazolyl-acylsulfonamides as potent inhibitors of HadAB/BC, a 3-hydroxyl-ACP deh
Autor:
Stephen Fienberg, Gregory S. Basarab, Anne J. Lenaerts, Virsinha Reddy, Sandeep R. Ghorpade, Mathew Njoroge, Grant A. Boyle, Charles J. Eyermann, Clifton E. Barry, Timothy G. Myers, Efrem Abay, Nina Lawrence, Alissa Myrick, Helena I. Boshoff, Vinayak Singh, Lutete Peguy Khonde, Lisa M. Massoudi, Paul D. van Helden, Frederick A. Sirgel, Gregory T. Robertson, Rudolf Müller, Kelly Chibale, Aloysius T. Nchinda, Qin Su
Publikováno v:
Journal of Medicinal Chemistry. 64:12790-12807
Phenotypic whole cell high-throughput screening of a ∼150,000 diverse set of compounds against Mycobacterium tuberculosis (Mtb) in cholesterol-containing media identified 1,3-diarylpyrazolyl-acylsulfonamide 1 as a moderately active hit. Structure-a
Autor:
Lauren B. Arendse, James M. Murithi, Tarrick Qahash, Charisse Flerida A. Pasaje, Luiz C. Godoy, Sumanta Dey, Liezl Gibhard, Sonja Ghidelli-Disse, Gerard Drewes, Marcus Bantscheff, Maria J. Lafuente-Monasterio, Stephen Fienberg, Lynn Wambua, Samuel Gachuhi, Dina Coertzen, Mariëtte van der Watt, Janette Reader, Ayesha S. Aswat, Erica Erlank, Nelius Venter, Nimisha Mittal, Madeline R. Luth, Sabine Ottilie, Elizabeth A. Winzeler, Lizette L. Koekemoer, Lyn-Marie Birkholtz, Jacquin C. Niles, Manuel Llinás, David A. Fidock, Kelly Chibale
Publikováno v:
Science Translational Medicine. 14
Compounds acting on multiple targets are critical to combating antimalarial drug resistance. Here, we report that the human “mammalian target of rapamycin” (mTOR) inhibitor sapanisertib has potent prophylactic liver stage activity, in vitro and i
Autor:
Lauren B, Arendse, James M, Murithi, Tarrick, Qahash, Charisse Flerida A, Pasaje, Luiz C, Godoy, Sumanta, Dey, Liezl, Gibhard, Sonja, Ghidelli-Disse, Gerard, Drewes, Marcus, Bantscheff, Maria J, Lafuente-Monasterio, Stephen, Fienberg, Lynn, Wambua, Samuel, Gachuhi, Dina, Coertzen, Mariëtte, van der Watt, Janette, Reader, Ayesha S, Aswat, Erica, Erlank, Nelius, Venter, Nimisha, Mittal, Madeline R, Luth, Sabine, Ottilie, Elizabeth A, Winzeler, Lizette L, Koekemoer, Lyn-Marie, Birkholtz, Jacquin C, Niles, Manuel, Llinás, David A, Fidock, Kelly, Chibale
Publikováno v:
Science translational medicine. 14(667)
Compounds acting on multiple targets are critical to combating antimalarial drug resistance. Here, we report that the human "mammalian target of rapamycin" (mTOR) inhibitor sapanisertib has potent prophylactic liver stage activity, in vitro and in vi
Autor:
Sergio Wittlin, Lynn Wambua, Luyanda Centani, Lauren B. Arendse, Lyn-Marie Birkholtz, Dale Taylor, Kelly Chibale, Janette Reader, Dina Coertzen, Nina Lawrence, Malkeet Kumar, Shoneeze S Renga, Peter Mubanga Cheuka, Stephen Fienberg, Godwin Akpeko Dziwornu, Mariëtte van der Watt
Publikováno v:
ACS Infectious Diseases. 7:34-46
Recent studies on 3,6-diphenylated imidazopyridazines have demonstrated impressive in vitro activity and in vivo efficacy in mouse models of malaria infection. Herein, we report the synthesis and antiplasmodium evaluation of a new series of amidated
Autor:
John E. Burke, Jacob A. McPhail, Charles J. Eyermann, Kelly Chibale, Stephen Fienberg, Gregory S. Basarab, Lauren B. Arendse
Publikováno v:
ACS Infectious Diseases. 6:3048-3063
Plasmodium falciparum phosphatidylinositol 4-kinase (PfPI4K) has emerged as a promising new drug target for novel antimalarial therapeutics. In the absence of a reliable high-resolution three-dimensional structure, a homology model of PfPI4K was buil
Autor:
Lutete Peguy, Khonde, Rudolf, Müller, Grant A, Boyle, Virsinha, Reddy, Aloysius T, Nchinda, Charles J, Eyermann, Stephen, Fienberg, Vinayak, Singh, Alissa, Myrick, Efrem, Abay, Mathew, Njoroge, Nina, Lawrence, Qin, Su, Timothy G, Myers, Helena I M, Boshoff, Clifton E, Barry, Frederick A, Sirgel, Paul D, van Helden, Lisa M, Massoudi, Gregory T, Robertson, Anne J, Lenaerts, Gregory S, Basarab, Sandeep R, Ghorpade, Kelly, Chibale
Publikováno v:
Journal of medicinal chemistry. 64(17)
Phenotypic whole cell high-throughput screening of a ∼150,000 diverse set of compounds against
Autor:
Peter Mubanga, Cheuka, Luyanda, Centani, Lauren B, Arendse, Stephen, Fienberg, Lynn, Wambua, Shoneeze S, Renga, Godwin Akpeko, Dziwornu, Malkeet, Kumar, Nina, Lawrence, Dale, Taylor, Sergio, Wittlin, Dina, Coertzen, Janette, Reader, Mariette, van der Watt, Lyn-Marie, Birkholtz, Kelly, Chibale
Publikováno v:
ACS infectious diseases. 7(1)
Recent studies on 3,6-diphenylated imidazopyridazines have demonstrated impressive