Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Stephen Fesik"'
Autor:
Gregory Caleb Howard, Jing Wang, Kristie L Rose, Camden Jones, Purvi Patel, Tina Tsui, Andrea C Florian, Logan Vlach, Shelly L Lorey, Brian C Grieb, Brianna N Smith, Macey J Slota, Elizabeth M Reynolds, Soumita Goswami, Michael R Savona, Frank M Mason, Taekyu Lee, Stephen Fesik, Qi Liu, William P Tansey
Publikováno v:
eLife, Vol 12 (2024)
The chromatin-associated protein WD Repeat Domain 5 (WDR5) is a promising target for cancer drug discovery, with most efforts blocking an arginine-binding cavity on the protein called the ‘WIN’ site that tethers WDR5 to chromatin. WIN site inhibi
Externí odkaz:
https://doaj.org/article/843d9e309e8c4e569cdd20374b77da61
Autor:
Steven W. Elmore, Saul H. Rosenberg, Stephen Fesik, Haichao Zhang, Xiufen Yang, Yu Xiao, Stephen K. Tahir, Lisa Roberts, Paul Nimmer, Michael J. Mitten, Kennan C. Marsh, Eric F. Johnson, Sha Jin, Jun Chen, Mark G. Anderson, Jessica Adickes, Alexander R. Shoemaker, Christin Tse
Supplementary Methods, Figures 1-7, Tables 1-2 from ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a5748135d4c615e9a225fa111035fc4
https://doi.org/10.1158/0008-5472.22376333
https://doi.org/10.1158/0008-5472.22376333
Autor:
Steven W. Elmore, Saul H. Rosenberg, Stephen Fesik, Haichao Zhang, Xiufen Yang, Yu Xiao, Stephen K. Tahir, Lisa Roberts, Paul Nimmer, Michael J. Mitten, Kennan C. Marsh, Eric F. Johnson, Sha Jin, Jun Chen, Mark G. Anderson, Jessica Adickes, Alexander R. Shoemaker, Christin Tse
Overexpression of the prosurvival Bcl-2 family members (Bcl-2, Bcl-xL, and Mcl-1) is commonly associated with tumor maintenance, progression, and chemoresistance. We previously reported the discovery of ABT-737, a potent, small-molecule Bcl-2 family
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6fdfedbecd630fa4945075cd99754bf
https://doi.org/10.1158/0008-5472.c.6498161
https://doi.org/10.1158/0008-5472.c.6498161
Autor:
Evan Perry, Jonathan J. Mills, Bin Zhao, Feng Wang, Qi Sun, Plamen P. Christov, James C. Tarr, Tyson A. Rietz, Edward T. Olejniczak, Taekyu Lee, Stephen Fesik
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:786-790
The PD-1 immune checkpoint pathway is a highly validated target for cancer immunotherapy. Despite the potential ad-vantages of small molecule inhibitors over antibodies, the discovery of small molecule checkpoint inhibitors has lagged behind. To disc