Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Stephen Falk"'
Autor:
Somnath Mukherjee, Christopher N. Hurt, Richard Adams, Andrew Bateman, Kevin M. Bradley, Sarah Bridges, Stephen Falk, Gareth Griffiths, Sarah Gwynne, Christopher M. Jones, Philip J. Markham, Tim Maughan, Lisette S. Nixon, Ganesh Radhakrishna, Rajarshi Roy, Simon Schoenbuchner, Hamid Sheikh, Emiliano Spezi, Maria Hawkins, Thomas D.L. Crosby
Publikováno v:
EClinicalMedicine, Vol 61, Iss , Pp 102059- (2023)
Summary: Background: The utility of early metabolic response assessment to guide selection of the systemic component of definitive chemoradiotherapy (dCRT) for oesophageal cancer is uncertain. Methods: In this multi-centre, randomised, open-label, ph
Externí odkaz:
https://doaj.org/article/138ca15545ee408b9e0a95d7b868e614
Autor:
Christopher M. Jones, Heather O'Connor, Maria O'Donovan, Daniel Hayward, Adrienn Blasko, Ruth Harman, Shalini Malhotra, Irene Debiram-Beecham, Bincy Alias, Adam Bailey, Andrew Bateman, Tom D.L. Crosby, Stephen Falk, Simon Gollins, Maria A. Hawkins, Sudarshan Kadri, Stephanie Levy, Ganesh Radhakrishna, Rajarshi Roy, Raj Sripadam, Rebecca C. Fitzgerald, Somnath Mukherjee
Publikováno v:
EClinicalMedicine, Vol 53, Iss , Pp 101664- (2022)
Summary: Background: Effective surveillance strategies are required for patients diagnosed with oesophageal squamous cell carcinoma (OSCC) or adenocarcinoma (OAC) for whom chemoradiotherapy (CRT) is used as a potentially-curative, organ-sparing, alte
Externí odkaz:
https://doaj.org/article/691654243a41434aa0d1850669448664
Autor:
Amanda Blatch-Jones, Jacqueline Nuttall, Abby Bull, Louise Worswick, Mark Mullee, Robert Peveler, Stephen Falk, Neil Tape, Jeremy Hinks, Athene J. Lane, Jeremy C. Wyatt, Gareth Griffiths
Publikováno v:
Trials, Vol 21, Iss 1, Pp 1-11 (2020)
Abstract Background Recruitment and retention of participants in randomised controlled trials (RCTs) is a key determinant of success but is challenging. Trialists and UK Clinical Research Collaboration (UKCRC) Clinical Trials Units (CTUs) are increas
Externí odkaz:
https://doaj.org/article/12aa37ec291b436c98861de96bc7c2f7
Autor:
Timothy Iveson, Kathleen A Boyd, Rachel S Kerr, Jose Robles-Zurita, Mark P Saunders, Andrew H Briggs, Jim Cassidy, Niels Henrik Hollander, Josep Tabernero, Andrew Haydon, Bengt Glimelius, Andrea Harkin, Karen Allan, John McQueen, Sarah Pearson, Ashita Waterston, Louise Medley, Charles Wilson, Richard Ellis, Sharadah Essapen, Amandeep S Dhadda, Mark Harrison, Stephen Falk, Sherif Raouf, Charlotte Rees, Rene K Olesen, David Propper, John Bridgewater, Ashraf Azzabi, David Farrugia, Andrew Webb, David Cunningham, Tamas Hickish, Andrew Weaver, Simon Gollins, Harpreet Wasan, James Paul
Publikováno v:
Health Technology Assessment, Vol 23, Iss 64 (2019)
Background: Oxaliplatin and fluoropyrimidine chemotherapy administered over 6 months is the standard adjuvant regimen for patients with high-risk stage II or III colorectal cancer. However, the regimen is associated with cumulative toxicity, characte
Externí odkaz:
https://doaj.org/article/4215111445164519a465163178fd46e0
Autor:
Chris Metcalfe, Kerry Avery, Richard Berrisford, Paul Barham, Sian M Noble, Aida Moure Fernandez, George Hanna, Robert Goldin, Jackie Elliott, Timothy Wheatley, Grant Sanders, Andrew Hollowood, Stephen Falk, Dan Titcomb, Christopher Streets, Jenny L Donovan, Jane M Blazeby
Publikováno v:
Health Technology Assessment, Vol 20, Iss 48 (2016)
Background: Localised oesophageal cancer can be curatively treated with surgery (oesophagectomy) but the procedure is complex with a risk of complications, negative effects on quality of life and a recovery period of 6–9 months. Minimal-access surg
Externí odkaz:
https://doaj.org/article/f84555b9772e4d3bb691f8c2351ea501
Autor:
Stephen Falk, Chris Williams
Lung cancer is the most common cancer affecting the industrialized world and affects the lives of thousands of people, including patients'friends and family, every year. The most common cause of lung cancer is long-term exposure to tobacco smoke. The
Autor:
Somnath Mukherjee, Christopher Nicholas Hurt, Richard A. Adams, Andrew Bateman, Kevin Bradley, Sarah Bridges, Stephen Falk, Gareth Griffiths, Sarah Gwynne, Christopher Jones, Philip Markham, Tim Maughan, Lisette Nixon, Ganesh Radhakrishna, Rajarshi Roy, Simon Schoenbuchner, Hamid Sheikh, Emiliano Spezi, Maria Hawkins, Tom Crosby
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ca8ed5984fa1dc6a837fdc8a8f3c067
https://doi.org/10.2139/ssrn.4380032
https://doi.org/10.2139/ssrn.4380032
Autor:
Janet Graham, Mahesh K. B. Parmar, Emma Yates, Tim Maughan, Jenny F. Seligmann, Louise Brown, David Fisher, Kai-Keen Shiu, Fiona Collinson, Ewan Brown, Philip Quirke, Stephen Falk, Richard H. Wilson, Susan D. Richman, Gary Middleton, Harpreet Wasan, Richard Kaplan, Richard Adams, Rachel Butler, Matthew T. Seymour, Leslie Samuel
Publikováno v:
Journal of Clinical Oncology. 39:3693-3704
PURPOSE Despite extensive randomized evidence supporting the use of treatment breaks in metastatic colorectal cancer (mCRC), they are not universally offered to patients despite improvements in quality of life without detriment to overall survival (O
Autor:
John V. Reynolds, Shaun R. Preston, Brian O'Neill, Maeve Aine Lowery, Lene Baeksgaard, Thomas Crosby, Moya Cunningham, Sinead Cuffe, Gareth Owen Griffiths, Rajarshi Roy, Stephen Falk, George Hanna, Frederick R. Bartlett, Imelda Parker, Alberto Alvarez-Iglesias, Magnus Nilsson, Guillaume Piessen, Signe Risum, Narayanasamy Ravi, Raymond S. McDermott
Publikováno v:
Journal of Clinical Oncology. 41:295-295
295 Background: The optimum combination curative approach to locally advanced adenocarcinoma of the esophagus and esophago-gastric junction (AEG) remains controversial, specifically whether multimodal therapy or perioperative chemotherapy is superior
Autor:
Benjamin R. Challoner, Andrew Woolston, David Lau, Marta Buzzetti, Caroline Fong, Louise J. Barber, Gayathri Anandappa, Richard Crux, Ioannis Assiotis, Kerry Fenwick, Ruwaida Begum, Dipa Begum, Tom Lund, Nanna Sivamanoharan, Harold B. Sansano, Melissa Domingo-Arada, Amina Tran, Bryony Eccles, Richard Ellis, Stephen Falk, Mark Hill, Daniel Krell, Nirupa Murugaesu, Luke Nolan, Vanessa Potter, Mark Saunders, Kai-Keen Shiu, Sebastian Guettler, James L. Alexander, Héctor Lázare-Iglesias, James Kinross, Jamie Murphy, Katharina von Loga, David Cunningham, Ian Chau, Naureen Starling, Juan Ruiz-Bañobre, Tony Dhillon, Marco Gerlinger
Mismatch repair deficient colorectal cancers have high mutation loads and many respond to immune checkpoint-inhibitors. We investigated how genetic and immune landscapes co-evolve in these tumors. All cases had high truncal mutation loads. Driver abe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b0034cbd8dbfa0674f6a03528d18c73
https://doi.org/10.1101/2022.02.16.479224
https://doi.org/10.1101/2022.02.16.479224