Výsledky vyhledávání - "Stephen F. Yates"

The new immunosuppression: intervention at the dendritic cell-T-cell interface

Autor: Kathleen F. Nolan, Stephen F. Yates, Herman Waldmann, Alison M. Paterson

Dendritic cells (DCs) play an important role in initiating and directing T-cells towards immunity or tolerance. An important aim of emerging immunosuppressive strategies is to ensure that antigen is perceived in a 'tolerogenic context'. This would ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33244c1e20e48b73c1a8c44460061616
https://doi.org/10.2174/156800805774912935

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Immune privilege induced by regulatory T cells in transplantation tolerance

Autor: Kathleen F. Nolan, Herman Waldmann, Paul J. Fairchild, Elizabeth Adams, Stephen F. Yates, Stephen P. Cobbold, Nathan J. Robertson, Alison M. Paterson, Stephen R. Daley, Luis Graca

Publikováno v: Immunological Reviews. 213:239-255

Immune privilege was originally believed to be associated with particular organs, such as the testes, brain, the anterior chamber of the eye, and the placenta, which need to be protected from any excessive inflammatory activity. It is now becoming cl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::838cbf58fa4efc19c04a2e0f624d0839
https://doi.org/10.1111/j.1600-065x.2006.00428.x

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Tolerogenicity is not an absolute property of a dendritic cell

Autor: Stephen F. Yates, Claire A. Farquhar, Paul J. Fairchild, Nigel J. Saunders, Elizabeth Adams, Kathleen F. Nolan, Hugo Garcia Rueda, Alison M. Paterson, Stephen P. Cobbold, Herman Waldmann

Publikováno v: European journal of immunology. 40(6)

Pharmacological modulation is known to temper the immune capacity of DC, enhancing the notion that modulated Ag-bearing DC might be used therapeutically to induce tolerance. We have investigated phenotypic features shared by such DC, and queried thei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b474c6b0907d7a16595758cf6f079628
http://ora.ox.ac.uk/objects/uuid:ad583f7f-c44d-4ce3-8a40-be16294cd677

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Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells

Autor: Stephen F. Yates, Elizabeth Adams, Masahide Tone, Mark Frewin, Yukiko Tone, Herman Waldmann, Stephen P. Cobbold

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 100(25)

Recently, agonist antibodies to glucocorticoid-induced tumor necrosis factor receptor (GITR) (tumor necrosis factor receptor superfamily 18) have been shown to neutralize the suppressive activity of CD4+CD25+regulatory T cells. It was anticipated tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::703975e35249ce1ab9c73cdc16436e0a
http://ora.ox.ac.uk/objects/uuid:f7fa0fc8-0d86-42a3-985a-d5b8858322c0

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Regulatory T cells and dendritic cells in transplantation tolerance: molecular markers and mechanisms

Autor: Stephen F. Yates, Mark Frewin, Raquel Castejon, Kathleen F. Nolan, Paul J. Fairchild, Herman Waldmann, Stephen P. Cobbold, Elizabeth Adams, Luis Graca, Susan Humm, Diana Zelenika, Alison M. Paterson, Sara A. J. Thompson, Alain Le Moine

Publikováno v: Immunological reviews. 196

Transplantation tolerance can be induced in adult rodents using monoclonal antibodies against coreceptor or costimulation molecules on the surface of T cells. There are currently two well-characterized populations of T cells, demonstrating regulatory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4db951b8d32fd4414a23e2fe311a8d4b
https://pubmed.ncbi.nlm.nih.gov/14617201

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