Zobrazeno 1 - 10
of 247
pro vyhledávání: '"Stephen F. Previs"'
Autor:
Margaret Wu, Ester Carballo-Jane, Haihong Zhou, Peter Zafian, Ge Dai, Mindy Liu, Julie Lao, Terri Kelly, Dan Shao, Judith Gorski, Dmitri Pissarnitski, Ahmet Kekec, Ying Chen, Stephen F. Previs, Giovanna Scapin, Yacob Gomez-Llorente, Scott A. Hollingsworth, Lin Yan, Danqing Feng, Pei Huo, Geoffrey Walford, Mark D. Erion, David E. Kelley, Songnian Lin, James Mu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/d6d3fdb3039843b9b530ac94e6eb34d2
Autor:
Margaret Wu, Ester Carballo-Jane, Haihong Zhou, Peter Zafian, Ge Dai, Mindy Liu, Julie Lao, Terri Kelly, Dan Shao, Judith Gorski, Dmitri Pissarnitski, Ahmet Kekec, Ying Chen, Stephen F. Previs, Giovanna Scapin, Yacob Gomez-Llorente, Scott A. Hollingsworth, Lin Yan, Danqing Feng, Pei Huo, Geoffrey Walford, Mark D. Erion, David E. Kelley, Songnian Lin, James Mu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Abstract Insulin analogs have been developed to treat diabetes with focus primarily on improving the time action profile without affecting ligand-receptor interaction or functional selectivity. As a result, inherent liabilities (e.g. hypoglycemia) of
Externí odkaz:
https://doaj.org/article/12bfc20a079d44f5b507280558359df6
Autor:
Santhosh Satapati, Daniel P. Downes, Daniel Metzger, Harish Shankaran, Saswata Talukdar, Yingjiang Zhou, Zhao Ren, Michelle Chen, Yeon-Hee Lim, Nathan G. Hatcher, Xiujuan Wen, Payal R. Sheth, David G. McLaren, Stephen F. Previs
Publikováno v:
SLAS Discovery, Vol 27, Iss 1, Pp 20-28 (2022)
Screening campaigns, especially those aimed at modulating enzyme activity, often rely on measuring substrate→product conversions. Unfortunately, the presence of endogenous substrates and/or products can limit one's ability to measure conversions. A
Externí odkaz:
https://doaj.org/article/103ba40a3e5a45859c5af8ed7bf87a21
Autor:
Ji Zhang, Eric S. Muise, Seongah Han, Peter S. Kutchukian, Philippe Costet, Yonghua Zhu, Yanqing Kan, Haihong Zhou, Vinit Shah, Yongcheng Huang, Ashmita Saigal, Taro E. Akiyama, Xiao-Lan Shen, Tian-Quan Cai, Kashmira Shah, Ester Carballo-Jane, Emanuel Zycband, Lan Yi, Ye Tian, Ying Chen, Jason Imbriglio, Elizabeth Smith, Kristine Devito, James Conway, Li-Jun Ma, Maarten Hoek, Iyassu K. Sebhat, Andrea M. Peier, Saswata Talukdar, David G. McLaren, Stephen F. Previs, Kristian K. Jensen, Shirly Pinto
Publikováno v:
Cell Reports Medicine, Vol 1, Iss 4, Pp 100056- (2020)
Summary: Fibrosis, or the accumulation of extracellular matrix, is a common feature of many chronic diseases. To interrogate core molecular pathways underlying fibrosis, we cross-examine human primary cells from various tissues treated with TGF-β, a
Externí odkaz:
https://doaj.org/article/063a70c64d8f4793abcfad76e4a93d9a
Autor:
Santhosh Satapati, Ying Qian, Margaret S. Wu, Aleksandr Petrov, Ge Dai, Sheng-ping Wang, Yonghua Zhu, Xiaolan Shen, Eric S. Muise, Ying Chen, Emanuel Zycband, Adam Weinglass, Jerry Di Salvo, John S. Debenham, Jason M. Cox, Ping Lan, Vinit Shah, Stephen F. Previs, Mark Erion, David E. Kelley, Liangsu Wang, Andrew D. Howard, Jin Shang
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 8, Pp 1561-1578 (2017)
GPR40 and GPR120 are fatty acid sensors that play important roles in glucose and energy homeostasis. GPR40 potentiates glucose-dependent insulin secretion and demonstrated in clinical studies robust glucose lowering in type 2 diabetes. GPR120 improve
Externí odkaz:
https://doaj.org/article/1d5d6bb81f4b48f7aa3c095bb5ab4e88
Autor:
Eric S Muise, Hong-Ping Guan, Jinqi Liu, Andrea R Nawrocki, Xiaodong Yang, Chuanlin Wang, Carlos G Rodríguez, Dan Zhou, Judith N Gorski, Marc M Kurtz, Danqing Feng, Kenneth J Leavitt, Lan Wei, Robert R Wilkening, James M Apgar, Shiyao Xu, Ku Lu, Wen Feng, Ying Li, Huaibing He, Stephen F Previs, Xiaolan Shen, Margaret van Heek, Sandra C Souza, Mark J Rosenbach, Tesfaye Biftu, Mark D Erion, David E Kelley, Daniel M Kemp, Robert W Myers, Iyassu K Sebhat
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0211568 (2019)
Physical activity promotes metabolic and cardiovascular health benefits that derive in part from the transcriptional responses to exercise that occur within skeletal muscle and other organs. There is interest in discovering a pharmacologic exercise m
Externí odkaz:
https://doaj.org/article/f28b2c263a184739b47d79a0d7b9272a
Autor:
Graeme F. Mason, Gerard Sanacora, Ying Chen, Douglas L. Rothman, Liza Gantert, Kenneth D. Anderson, Stephen F. Previs, Corin O. Miller, Justina M. Thomas, Jason M. Uslaner
Publikováno v:
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 7:598-606
Background The development of treatments for cognitive deficits associated with central nervous system disorders is currently a significant medical need. Despite the great need for such therapeutics, a significant challenge in the drug development pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f35e6664236c9b7a418102a2157076e5
https://doi.org/10.1016/j.bpsc.2020.09.014
https://doi.org/10.1016/j.bpsc.2020.09.014
Autor:
Kristian K. Jensen, Marija Tadin-Strapps, Sheng-ping Wang, James Hubert, Yanqing Kan, Yong Ma, David G. McLaren, Stephen F. Previs, Kithsiri B. Herath, Ablatt Mahsut, Andy Liaw, Shubing Wang, Steven J. Stout, CarolAnn Keohan, Gail Forrest, David Coelho, Satya Yendluri, Stephanie Williams, Martin Koser, Steven Bartz, Karen O. Akinsanya, Shirly Pinto
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 12, Pp 2150-2162 (2016)
SREBP cleavage-activating protein (SCAP) is a key protein in the regulation of lipid metabolism and a potential target for treatment of dyslipidemia. SCAP is required for activation of the transcription factors SREBP-1 and -2. SREBPs regulate the exp
Externí odkaz:
https://doaj.org/article/bd0a1abbb701431196775362cf9f8457
Autor:
David G. McLaren, Stephen F. Previs, Robert D. Phair, Steven J. Stout, Dan Xie, Ying Chen, Gino M. Salituro, Suoyu S. Xu, Jose M. Castro-Perez, Gregory J. Opiteck, Karen O. Akinsanya, Michele A. Cleary, Hayes M. Dansky, Douglas G. Johns, Thomas P. Roddy
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 3, Pp 398-409 (2016)
Studies in lipoprotein kinetics almost exclusively rely on steady-state approaches to modeling. Herein, we have used a non-steady-state experimental design to examine the role of cholesteryl ester transfer protein (CETP) in mediating HDL-TG flux in v
Externí odkaz:
https://doaj.org/article/5fbca9dec0944cbaae6bb25b8975fe09
Autor:
Richard Johnstone, Zhao Ren, Myung K. Shin, Maarten Hoek, Haihong Zhou, Anthony Kreamer, Mary-Jo Wildey, Jason E. Imbriglio, Stephen F. Previs, Xi Ai, Andrea M. Peier, Steve Cifelli, Lufei Hu, Ashmita Saigal, Josephine Johnson, Richard Visconti, Yanqing Kan, Lin-Lin Shiao, William T. McElroy, Jonathan W. Choy, Adam B. Weinglass, Ying Lei, Robert Ramos, Andy Liaw, Michelle Chen
Publikováno v:
SLAS Discovery. 26:1225-1237
High-throughput phenotypic screening is a key driver for the identification of novel chemical matter in drug discovery for challenging targets, especially for those with an unclear mechanism of pathology. For toxic or gain-of-function proteins, small
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d4441c7993243e64c0eaf4458d6e4f2
https://doi.org/10.1177/24725552211026245
https://doi.org/10.1177/24725552211026245