Insights into Polyether Biosynthesis from Analysis of the Nigericin Biosynthetic Gene Cluster in Streptomyces sp. DSM4137

Autor: Yuhui Sun, Tatiana Mironenko, Kira J. Weissman, Peter F. Leadlay, Zixin Deng, Stephen F. Haydock, Barbara M. Harvey, Hui Hong

Publikováno v: Chemistry & Biology. 14(6):703-714

SummaryNigericin was among the first polyether ionophores to be discovered, but its biosynthesis remains obscure. The biosynthetic gene cluster for nigericin has been serendipitously cloned from Streptomyces sp. DSM4137, and deletion of this gene clu

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Effect of overexpressed adenylyl cyclase VI onβ1- andβ2-adrenoceptor responses in adult rat ventricular myocytes

Autor: Roger Foo, Stephen F. Haydock, Morris J. Brown, Joalice C C Stark, Sian E. Harding

Publikováno v: British Journal of Pharmacology. 143:465-476

1. Adenylyl cyclase VI (ACVI) is one of the most abundantly expressed beta adrenergic receptor (betaAR)-coupled cyclases responsible for cyclic AMP (cAMP) production within the mammalian myocardium. We investigated the role of ACVI in the regulation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e8c01169d7e098a1d4f649a1c5959038
https://doi.org/10.1038/sj.bjp.0705976

Biosynthetic Gene Cluster of the Glycopeptide Antibiotic Teicoplanin

Autor: Peter F. Leadlay, Fanglu Huang, Stephen F. Haydock, Tsung-Lin Li, Jonathan B. Spencer, Tatiana Mironenko

Publikováno v: Chemistry & Biology. 11:107-119

The gene cluster encoding biosynthesis of the clinically important glycopeptide antibiotic teicoplanin has been cloned from Actinoplanes teichomyceticus . Forty-nine putative open reading frames (ORFs) were identified within an 89 kbp genetic locus a

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https://doi.org/10.1016/j.chembiol.2004.01.001

The admission of older patients to a dedicated short stay medical unit: learning from experience

Autor: Tadbir Kaur Bariana, Simi Rosy Pereira, Gavin S. Chu, Matthew R. Hayman, Taeko Becque, Stephen F Haydock

Publikováno v: Acute Medicine Journal. 6:121-123

The admission of older patients with acute medical problems to short stay medical units (SSMUs) is controversial in light of their longer expected length of in-patient stay (LoS), coupled with the greater resources required by such a department. We u

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https://doi.org/10.52964/amja.0177

Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: Analysis of the enzymatic domains in the modular polyketide synthase

Autor: Ariane König, James Staunton, Jesús F. Aparicio, Lake Ee Khaw, Stephen F. Haydock, Peter F. Leadlay, Torsten Schwecke, István Molnár

Publikováno v: Aparicio, J F, Molnár, I, Schwecke, T, König, A, Haydock, S F, Khaw, L E, Staunton, J & Leadlay, P F 1996, ' Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus : Analysis of the enzymatic domains in the modular polyketide synthase ', Gene, vol. 169, no. 1, pp. 9-16 . https://doi.org/10.1016/0378-1119(95)00800-4

The three giant multifunctional polypeptides of the rapamycin (Rp)-producing polyketide synthase (RAPS1, RAPS2 and RAPS3) have recently been shown to contain 14 separate sets, or modules, of enzyme activities, each module catalysing a specific round

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06cf7d603ad01719c228d7204b108f5a
https://doi.org/10.1016/0378-1119(95)00800-4