Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Stephen F. Flaim"'
Autor:
Viktor V. Obraztsov, Gerald G. Neslund, Stephen F. Flaim, Elisabeth S. Kornbrust, Catherine M. Woods
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 278:L1018-L1024
Preclinical studies comparing perflubron partial liquid ventilation with conventional mechanical ventilation have indicated that perflubron partial liquid ventilation may exert some anti-inflammatory effects. To assess whether these effects were rela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdfaa9bec2594479d4e2a7e0265aba72
https://doi.org/10.1152/ajplung.2000.278.5.l1018
https://doi.org/10.1152/ajplung.2000.278.5.l1018
Publikováno v:
Journal of Cardiovascular Pharmacology. 16:546-556
The purpose of this study was to evaluate the cardiac electrophysiological effects of McN-5691, a new calcium-channel blocking antihypertensive drug. In anesthetized dogs, the primary electrophysiological effect of McN-5691 was dose-related prolongat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b05d2ff88084a2cfe2945f6614841688
https://doi.org/10.1097/00005344-199010000-00005
https://doi.org/10.1097/00005344-199010000-00005
Publikováno v:
Journal of Cardiovascular Pharmacology. 15:780-790
The purpose of this study was to characterize the cardiocirculatory effects of the novel calcium channel blocker, McN-6186 (McN), normal, conscious rats. Animals were instrumented under halothane anesthesia for right atrial, left ventricular, arteria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c31991e1e92909dca516114ddfba7d56
https://doi.org/10.1097/00005344-199005000-00014
https://doi.org/10.1097/00005344-199005000-00014
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 278(5)
Infiltration of activated neutrophils into the lung appears to be a key element in the severe lung injury that develops in animal models of acute lung injury. Partial liquid ventilation with perflubron has been shown to ameliorate tissue damage compa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::973c9caf4a3b67811d581e4e1658b2ee
https://pubmed.ncbi.nlm.nih.gov/10781432
https://pubmed.ncbi.nlm.nih.gov/10781432
Autor:
Stephen F. Flaim
Publikováno v:
Advances in Blood Substitutes ISBN: 9781461273639
The data summarized in this chapter constitutes the preclinical efficacy experience with perflubron-based emulsion. These data support the conclusion that IV perflubron-based emulsion improves tissue oxygenation in critical tissues such as heart and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f30b0f1c87cbd8493fe8406b087ae7e4
https://doi.org/10.1007/978-1-4612-1976-7_6
https://doi.org/10.1007/978-1-4612-1976-7_6
Autor:
Stephen F. Flaim
Publikováno v:
Artificial cells, blood substitutes, and immobilization biotechnology. 22(4)
Perfluorochemicals are fluorine-saturated carbon-based molecules which demonstrate utility in the areas of imaging and oxygen delivery. In general, these molecules are biologically inert and, therefore, do not pose toxicologic risk from metabolic deg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a7c52efab1179b8b1a7cd13a7ebaecf
https://pubmed.ncbi.nlm.nih.gov/7849908
https://pubmed.ncbi.nlm.nih.gov/7849908
Publikováno v:
The American journal of cardiology. 69(11)
Bepridil is an antianginal agent with multiple therapeutic actions. It decreases calcium influx through potential-dependent and receptor-operated sarcolemmic calcium channels and acts intracellularly as a calmodulin antagonist and calcium sensitizer.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97cbbb930074d29e038826b09f34d470
https://pubmed.ncbi.nlm.nih.gov/1372785
https://pubmed.ncbi.nlm.nih.gov/1372785
Publikováno v:
The American Journal of Cardiology. 49:511-518
One of the major mechanisms of action of the drugs called calcium channel blocking agents in vascular smooth muscle is the inhibition of the influx of calcium ion across the sarcolemmal membrane during cellular activation. However, a growing body of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c8a836ded88bb2ac7400246f4a5be92
https://doi.org/10.1016/s0002-9149(82)80004-0
https://doi.org/10.1016/s0002-9149(82)80004-0
Autor:
William P. Graham, Stephen H. Nellis, Stephen F. Flaim, Thomas S. Davis, Thomas J. Kennedy, David C. Buck, Stephen H. Miller
Publikováno v:
Annals of Surgery. 193:255-263
A canine model was developed to simulate use of a pneumatic tourniquet in the clinical setting in order to study the acute and delayed effects of transient ischemia on limb and tissue blood flow, using radioactive microspheres and electromagnetic flo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a3ab2c8ad2ec3ea8b771b8d61ece15d
https://doi.org/10.1097/00000658-198103000-00001
https://doi.org/10.1097/00000658-198103000-00001