Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Stephen F. Carr"'
Autor:
Hailong Guo, Bomsoo Cho, Paul R. Hinton, Sijia He, Yongjun Yu, Ashwin Kumar Ramesh, Jwala Priyadarsini Sivaccumar, Zhiqiang Ku, Kristen Campo, Sarah Holland, Sameer Sachdeva, Christopher Mensch, Mohamed Dawod, Annalis Whitaker, Philip Eisenhauer, Allison Falcone, Rebekah Honce, Jason W. Botten, Stephen F. Carroll, Bruce A. Keyt, Andrew W. Womack, William R. Strohl, Kai Xu, Ningyan Zhang, Zhiqiang An, Sha Ha, John W. Shiver, Tong-Ming Fu
Publikováno v:
Emerging Microbes and Infections, Vol 12, Iss 2 (2023)
The capacity of SARS-CoV-2 to evolve poses challenges to conventional prevention and treatment options such as vaccination and monoclonal antibodies, as they rely on viral receptor binding domain (RBD) sequences from previous strains. Additionally, a
Externí odkaz:
https://doaj.org/article/b32daa709614466280c100d037969216
Autor:
Kevin C. Hart, Daniel Santos, Deepal Pandya, Rong Deng, Keyu LI, Yinghui Guan, Genevive Hernandez, Thomas Manley, Maya K. Leabman, Paul R. Hinton, Liqin Liu, Angus M. Sinclair, Albert F. Candia, Stephen F. Carroll, Bruce A. Keyt, Maya F. Kotturi
Publikováno v:
HemaSphere, Vol 7, p e630565c (2023)
Externí odkaz:
https://doaj.org/article/eec65130efac469185c57723fcdf2227
Autor:
Krystyna Lesiak, Stephen F. Carr, Marek Sochacki, Alokes Majumdar, Krzysztof W. Pankiewicz, Kyoichi A. Watanabe, Barry M. Goldstein, Andrzej Zatorski, Michael M. Seidman
Publikováno v:
Journal of Medicinal Chemistry. 40:1287-1291
beta-Methylene-BAD (8), a nonhydrolyzable analogue of benzamide adenine dinucleotide (BAD), was synthesized as potential inhibitor of human inosine monophosphate dehydrogenase (IMPDH). Treatment of 2',3'-O-isopropylideneadenosine 5'-methylenebisphosp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c550e790bd07c95eb636f323258c5138
https://doi.org/10.1021/jm960641y
https://doi.org/10.1021/jm960641y
Autor:
Han-Zhong Zhang, Eva Papp, John C. Wu, Kotesvar Rao, Kenneth Straub, Stephen F. Carr, Josef Fried
Publikováno v:
Journal of Medicinal Chemistry. 40:4-8
Functionalized 2-alkyl derivatives of inosinic acid have been synthesized to serve as reversible as well as irreversible inhibitors of the human type II enzyme inosine monophosphate dehydrogenase. These compounds were designed to react with Cys-331 o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1142fc797851bb6553231b017bc89806
https://doi.org/10.1021/jm960732v
https://doi.org/10.1021/jm960732v
Autor:
Carlos Gonzalez, Stephen F. Carr, Elsie M. Eugui, Rebecca A. Stephenson, Fidencio Franco, Peter H. Nelson, Ann-Marie Waltos, Eric Brian Sjogren, Sussan Rouhafza, Francisco Xavier Talamas, Ronald Charles Hawley, Devens Bruce H, David G. Loughhead, Robert James Weikert, Patterson John W, Eva Papp, David J. Milan, John C. Wu, David Bernard Smith
Publikováno v:
Journal of Medicinal Chemistry. 39:4181-4196
Structure-activity relationships in the region of the phthalide ring of the inosine monophosphate dehydrogenase inhibitor mycophenolic acid have been explored. Replacement of the lactone ring with other cyclic moieties resulted in loss of potency, es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ff036a2797b977cf77932866612aa31
https://doi.org/10.1021/jm9603633
https://doi.org/10.1021/jm9603633
Autor:
Denes Medzihradszky, Ming S. Chen, Stephen F. Carr, Daniel V. Santit, John C. Wu, Kurt Jarnagin, Jim W. Barnett, Hardy W. Chan, Donald Yamashiro, Steven Kirsher, Joan Chow
Publikováno v:
Archives of Biochemistry and Biophysics. 277:306-311
A 99-amino acid protein having the deduced sequence of the protease from human immunodeficiency virus type 2 (HIV-2) was synthesized by the solid phase method and tested for specificity. The folded peptide catalyzes specific processing of a recombina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd5f369c181562e3dc406dd7f1be9c7f
https://doi.org/10.1016/0003-9861(90)90584-l
https://doi.org/10.1016/0003-9861(90)90584-l
Autor:
Barry M. Goldstein, Krzysztof W. Pankiewicz, Stephen F. Carr, Andrzej Zatorski, Kyoichi A. Watanabe
Publikováno v:
Journal of medicinal chemistry. 39(12)
Treatment of 3-(2,3-O-isopropylidene-beta-D-ribofuranosyl)benzamide (6) with POCl3 in (EtO)3-PO afforded only little phosphorylation product (8, 5%), but the major product was 5'-chlorobenzamide riboside (7, 85%). Reaction of 6 with 2-cyanoethyl N,N-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07f164be3e5ae26b37e2f171dacf8b1c
https://pubmed.ncbi.nlm.nih.gov/8691436
https://pubmed.ncbi.nlm.nih.gov/8691436
Autor:
Stephen F. Carr, Yutaka Natsumeda
Publikováno v:
Annals of the New York Academy of Sciences. 696
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0203c3332c6fa613bbf4af84d2037e23
https://pubmed.ncbi.nlm.nih.gov/7906497
https://pubmed.ncbi.nlm.nih.gov/7906497
Autor:
Seung-Uon Shin, Hyun-Mi Cho, Rathin Das, Hava Gil-Henn, Sundaram Ramakrishnan, Ahmed Al Bayati, Stephen F. Carroll, Yu Zhang, Ankita P. Sankar, Christian Elledge, Augustin Pimentel, Marzenna Blonska, Joseph D. Rosenblatt
Publikováno v:
Cells, Vol 10, Iss 11, p 2904 (2021)
Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype with limited therapeutic options. Metastasis is the major cause of TNBC mortality. Angiogenesis facilitates TNBC metastases. Many TNBCs also form vascular channels lined by t
Externí odkaz:
https://doaj.org/article/d368352d13854fed8120ade6326d597c
Publikováno v:
Antibodies, Vol 9, Iss 4, p 53 (2020)
Natural immunoglobulin M (IgM) antibodies are pentameric or hexameric macro-immunoglobulins and have been highly conserved during evolution. IgMs are initially expressed during B cell ontogeny and are the first antibodies secreted following exposure
Externí odkaz:
https://doaj.org/article/07d7cd4f3fa94a508c39b3bdd6743fd8