Zobrazeno 1 - 10
of 174
pro vyhledávání: '"Stephen F Previs"'
Autor:
Eric S Muise, Hong-Ping Guan, Jinqi Liu, Andrea R Nawrocki, Xiaodong Yang, Chuanlin Wang, Carlos G Rodríguez, Dan Zhou, Judith N Gorski, Marc M Kurtz, Danqing Feng, Kenneth J Leavitt, Lan Wei, Robert R Wilkening, James M Apgar, Shiyao Xu, Ku Lu, Wen Feng, Ying Li, Huaibing He, Stephen F Previs, Xiaolan Shen, Margaret van Heek, Sandra C Souza, Mark J Rosenbach, Tesfaye Biftu, Mark D Erion, David E Kelley, Daniel M Kemp, Robert W Myers, Iyassu K Sebhat
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0211568 (2019)
Physical activity promotes metabolic and cardiovascular health benefits that derive in part from the transcriptional responses to exercise that occur within skeletal muscle and other organs. There is interest in discovering a pharmacologic exercise m
Externí odkaz:
https://doaj.org/article/f28b2c263a184739b47d79a0d7b9272a
Autor:
Margaret Wu, Ester Carballo-Jane, Haihong Zhou, Peter Zafian, Ge Dai, Mindy Liu, Julie Lao, Terri Kelly, Dan Shao, Judith Gorski, Dmitri Pissarnitski, Ahmet Kekec, Ying Chen, Stephen F. Previs, Giovanna Scapin, Yacob Gomez-Llorente, Scott A. Hollingsworth, Lin Yan, Danqing Feng, Pei Huo, Geoffrey Walford, Mark D. Erion, David E. Kelley, Songnian Lin, James Mu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/d6d3fdb3039843b9b530ac94e6eb34d2
Autor:
Santhosh Satapati, Daniel P. Downes, Daniel Metzger, Harish Shankaran, Saswata Talukdar, Yingjiang Zhou, Zhao Ren, Michelle Chen, Yeon-Hee Lim, Nathan G. Hatcher, Xiujuan Wen, Payal R. Sheth, David G. McLaren, Stephen F. Previs
Publikováno v:
SLAS Discovery, Vol 27, Iss 1, Pp 20-28 (2022)
Screening campaigns, especially those aimed at modulating enzyme activity, often rely on measuring substrate→product conversions. Unfortunately, the presence of endogenous substrates and/or products can limit one's ability to measure conversions. A
Externí odkaz:
https://doaj.org/article/103ba40a3e5a45859c5af8ed7bf87a21
Autor:
Ji Zhang, Eric S. Muise, Seongah Han, Peter S. Kutchukian, Philippe Costet, Yonghua Zhu, Yanqing Kan, Haihong Zhou, Vinit Shah, Yongcheng Huang, Ashmita Saigal, Taro E. Akiyama, Xiao-Lan Shen, Tian-Quan Cai, Kashmira Shah, Ester Carballo-Jane, Emanuel Zycband, Lan Yi, Ye Tian, Ying Chen, Jason Imbriglio, Elizabeth Smith, Kristine Devito, James Conway, Li-Jun Ma, Maarten Hoek, Iyassu K. Sebhat, Andrea M. Peier, Saswata Talukdar, David G. McLaren, Stephen F. Previs, Kristian K. Jensen, Shirly Pinto
Publikováno v:
Cell Reports Medicine, Vol 1, Iss 4, Pp 100056- (2020)
Summary: Fibrosis, or the accumulation of extracellular matrix, is a common feature of many chronic diseases. To interrogate core molecular pathways underlying fibrosis, we cross-examine human primary cells from various tissues treated with TGF-β, a
Externí odkaz:
https://doaj.org/article/063a70c64d8f4793abcfad76e4a93d9a
Autor:
Graeme F. Mason, Gerard Sanacora, Ying Chen, Douglas L. Rothman, Liza Gantert, Kenneth D. Anderson, Stephen F. Previs, Corin O. Miller, Justina M. Thomas, Jason M. Uslaner
Publikováno v:
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 7:598-606
Background The development of treatments for cognitive deficits associated with central nervous system disorders is currently a significant medical need. Despite the great need for such therapeutics, a significant challenge in the drug development pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f35e6664236c9b7a418102a2157076e5
https://doi.org/10.1016/j.bpsc.2020.09.014
https://doi.org/10.1016/j.bpsc.2020.09.014
Autor:
Richard Johnstone, Zhao Ren, Myung K. Shin, Maarten Hoek, Haihong Zhou, Anthony Kreamer, Mary-Jo Wildey, Jason E. Imbriglio, Stephen F. Previs, Xi Ai, Andrea M. Peier, Steve Cifelli, Lufei Hu, Ashmita Saigal, Josephine Johnson, Richard Visconti, Yanqing Kan, Lin-Lin Shiao, William T. McElroy, Jonathan W. Choy, Adam B. Weinglass, Ying Lei, Robert Ramos, Andy Liaw, Michelle Chen
Publikováno v:
SLAS Discovery. 26:1225-1237
High-throughput phenotypic screening is a key driver for the identification of novel chemical matter in drug discovery for challenging targets, especially for those with an unclear mechanism of pathology. For toxic or gain-of-function proteins, small
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d4441c7993243e64c0eaf4458d6e4f2
https://doi.org/10.1177/24725552211026245
https://doi.org/10.1177/24725552211026245
Autor:
Kithsiri Herath, Athula B. Attygalle, Sheo B. Singh, Olga Genilloud, Thomas P. Roddy, Stephen F. Previs, Ignacio González
Publikováno v:
Journal of Natural Products. 84:814-823
Natural product congeners serve a useful role in the understanding of natural product biosynthesis and structure-activity relationships. A minor congener with superior activity, selectivity, and modifiable functional groups could serve as a more effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e12a7e9798a8198be4b1ea09ccc8b86
https://doi.org/10.1021/acs.jnatprod.0c01190
https://doi.org/10.1021/acs.jnatprod.0c01190
Autor:
Wendy Zhong, David G. McLaren, Daniel Metzger, Ji Zhang, Daniel P. Downes, Payal R. Sheth, Saswata Talukdar, Julie Lao, Guillermo Godinez, Santhosh Satapati, Stephen F. Previs, Bingming Chen
Publikováno v:
Journal of the American Society for Mass Spectrometry. 31:2421-2425
Spatial characterization of triglyceride metabolism is an area of significant interest which can be enabled by mass spectrometry imaging via recent advances in neutral lipid laser desorption analytical approaches. Here, we extend recent advancements
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e430a07c92e09419f91d3322277c78f
https://doi.org/10.1021/jasms.0c00199
https://doi.org/10.1021/jasms.0c00199
Autor:
Margaret Wu, Ester Carballo-Jane, Haihong Zhou, Peter Zafian, Ge Dai, Mindy Liu, Julie Lao, Terri Kelly, Dan Shao, Judith Gorski, Dmitri Pissarnitski, Ahmet Kekec, Ying Chen, Stephen F. Previs, Giovanna Scapin, Yacob Gomez Llorente, Scott A. Hollingsworth, Lin Yan, Danqing Feng, Pei Huo, Geoffrey Walford, Mark D. Erion, David E. Kelley, Songnian Lin, James Mu
Publikováno v:
Nature communications. 13(1)
Insulin analogs have been developed to treat diabetes with focus primarily on improving the time action profile without affecting ligand-receptor interaction or functional selectivity. As a result, inherent liabilities (e.g. hypoglycemia) of injectab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad1b1ab72351f303daeb431c6316f1a1
https://pubmed.ncbi.nlm.nih.gov/35177603
https://pubmed.ncbi.nlm.nih.gov/35177603
Autor:
Bao Jen Shyong, David G. McLaren, Maria Webb, Joel Mane, Stephen F. Previs, Haihong Zhou, David E. Kelley, Carlos G. Rodriguez, Kevin P. Bateman, Yichen Wang, Daniel P. Downes, Natalie A. Daurio, George H. Addona, Andrea K. Houghton, Ying Chen, Peter Zafian, Ester Carballo-Jane, Rena Zhang
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 316:E1105-E1117
The regulation of nutrient homeostasis, i.e., the ability to transition between fasted and fed states, is fundamental in maintaining health. Since food is typically consumed over limited (anabolic) periods, dietary components must be processed and st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::859551c265999db7b7b6deaead504442
https://doi.org/10.1152/ajpendo.00459.2018
https://doi.org/10.1152/ajpendo.00459.2018