Výsledky vyhledávání - "Stephen F Fitzgerald"

Akademický článek

Shiga toxin sub-type 2a increases the efficiency of Escherichia coli O157 transmission between animals and restricts epithelial regeneration in bovine enteroids.

Autor: Stephen F Fitzgerald, Amy E Beckett, Javier Palarea-Albaladejo, Sean McAteer, Sharif Shaaban, Jason Morgan, Nur Indah Ahmad, Rachel Young, Neil A Mabbott, Liam Morrison, James L Bono, David L Gally, Tom N McNeilly

Publikováno v: PLoS Pathogens, Vol 15, Iss 10, p e1008003 (2019)

Specific Escherichia coli isolates lysogenised with prophages that express Shiga toxin (Stx) can be a threat to human health, with cattle being an important natural reservoir. In many countries the most severe pathology is associated with enterohaemo

Externí odkaz: https://doaj.org/article/ad10677444214439b98e2647c5326521

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Akademický článek

Genome-wide epitope mapping across multiple host species reveals significant diversity in antibody responses to Coxiella burnetii vaccination and infection

Autor: Emil Bach, Stephen F. Fitzgerald, Sarah E. Williams-MacDonald, Mairi Mitchell, William T. Golde, David Longbottom, Alasdair J. Nisbet, Annemieke Dinkla, Eric Sullivan, Richard S. Pinapati, John C. Tan, Leo A. B. Joosten, Hendrik-Jan Roest, Thomas Østerbye, Ad P. Koets, Søren Buus, Tom N. McNeilly

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Coxiella burnetii is an important zoonotic bacterial pathogen of global importance, causing the disease Q fever in a wide range of animal hosts. Ruminant livestock, in particular sheep and goats, are considered the main reservoir of human infection.

Externí odkaz: https://doaj.org/article/55700a5c8dce43b49b05a921f1048029

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Akademický článek

Prevalence of Shiga Toxin-Producing Escherichia coli O157 in Wild Scottish Deer with High Human Pathogenic Potential

Autor: Stephen F. Fitzgerald, Mairi C. Mitchell, Anne Holmes, Lesley Allison, Margo Chase-Topping, Nadejda Lupolova, Beth Wells, David L. Gally, Tom N. McNeilly

Publikováno v: Animals, Vol 13, Iss 17, p 2795 (2023)

Shiga toxin-producing E. coli (STEC) infections associated with wildlife are increasing globally, highlighting many ‘spillover’ species as important reservoirs for these zoonotic pathogens. A human outbreak of STEC serogroup O157 in 2015 in Scotl

Externí odkaz: https://doaj.org/article/baae74794d504346a7589463fc82fae1

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Akademický článek

Efficacy of Phase I and Phase II Coxiella burnetii Bacterin Vaccines in a Pregnant Ewe Challenge Model

Autor: Sarah E. Williams-Macdonald, Mairi Mitchell, David Frew, Javier Palarea-Albaladejo, David Ewing, William T. Golde, David Longbottom, Alasdair J. Nisbet, Morag Livingstone, Clare M. Hamilton, Stephen F. Fitzgerald, Søren Buus, Emil Bach, Annemieke Dinkla, Hendrik-Jan Roest, Ad P. Koets, Tom N. McNeilly

Publikováno v: Vaccines, Vol 11, Iss 3, p 511 (2023)

The bacterium Coxiella burnetii can cause the disease Q-fever in a wide range of animal hosts. Ruminants, including sheep, are thought to play a pivotal role in the transmission of C. burnetii to humans; however, the only existing livestock vaccine,

Externí odkaz: https://doaj.org/article/aa3c2c8447b9405e9658bda2802a97a5

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A mutation in the putative CRP binding site of the dctA promoter of Salmonella enterica serovar Typhimurium enables growth with low orotate concentrations

Autor: Mohammad R. Amin, Lisa Korchinski, Joshua K. Yoneda, Rishi Thakkar, Carla L.A. Sanson, Stephen F. Fitzgerald, Rod A. Kelln, Andrew D.S. Cameron

Publikováno v: Canadian Journal of Microbiology. 68:615-621

Salmonella enterica and Escherichia coli use the inner membrane transporter DctA to import the pyrimidine biosynthetic pathway intermediate orotate from the environment. To study the regulation of dctA expression, we used an S. enterica serovar Typhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::34d7b496e78307c55d4c510da3ffaac9
https://doi.org/10.1139/cjm-2022-0120

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Redefining the H-NS protein family: a diversity of specialized core and accessory forms exhibit hierarchical transcriptional network integration

Autor: Daniel M. Stoebel, Stefani C. Kary, Andrew D. S. Cameron, Tzu-Chiao Chao, Ebtihal Y Alshabib, Stephen F. Fitzgerald, Keith D. MacKenzie

Publikováno v: Fitzgerald, S, Kary, S C, Alshbib, E Y, Mackenzie, K D, Stoebel, D M, Chao, T-C & Cameron, A D S 2020, ' Redefining the H-NS protein family: a diversity of specialized core and accessory forms exhibit hierarchical transcriptional network integration ', Nucleic Acids Research . https://doi.org/10.1093/nar/gkaa709
Nucleic Acids Research

H-NS is a nucleoid structuring protein and global repressor of virulence and horizontally-acquired genes in bacteria. H-NS can interact with itself or with homologous proteins, but protein family diversity and regulatory network overlap remain poorly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc47b6df31342cf811a513685a654327
https://doi.org/10.1093/nar/gkaa709

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Site specific relationships between COVID-19 cases and SARS-CoV-2 viral load in wastewater treatment plant influent

Autor: Gianluigi Rossi, Davey L. Jones, Brian O'Keefe, Stephen F. Fitzgerald, Graeme J Cameron, Peter Pollard, Alexander Corbishley, Andrew C. Singer, Sean P. McAteer, Rowland R. Kao, David W. Graham, David Findlay, Alison S. Low, David L. Gally, Christine Tait-Burkard, Peter T. R. Singleton, Marcos Quintela-Baluja, George Ponton, Kata Farkas

Publikováno v: Fitzgerald, S, Rossi, G, Low, A, McAteer, S, O’Keefe, B, Findlay, D, Cameron, G J, Pollard, P, Singleton, P T R, Ponton, G, Singer, A C, Farkas, K, Jones, D, Graham, D W, Quintela-Baluja, M, Tait-Burkard, C, Gally, D, Kao, R & Corbishley, A 2021, ' Site specific relationships between COVID-19 cases and SARS-CoV-2 viral load in wastewater treatment plant influent ', Environmental Science and Technology . https://doi.org/10.1021/acs.est.1c05029
Environmental Science & Technology

Wastewater based epidemiology (WBE) has become an important tool during the COVID-19 pandemic, however the relationship between SARS-CoV-2 RNA in wastewater treatment plant influent (WWTP) and cases in the community is not well-defined. We report her

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb95e61f3c9bdf5fc4656df71f1e9963

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Genome structural variation in

Autor: Stephen F, Fitzgerald, Nadejda, Lupolova, Sharif, Shaaban, Timothy J, Dallman, David, Greig, Lesley, Allison, Sue C, Tongue, Judith, Evans, Madeleine K, Henry, Tom N, McNeilly, James L, Bono, David L, Gally

Publikováno v: Microbial Genomics

The human zoonotic pathogen Escherichia coli O157:H7 is defined by its extensive prophage repertoire including those that encode Shiga toxin, the factor responsible for inducing life-threatening pathology in humans. As well as introducing genes that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::08ac60a812a084a913ed3b4918ea4cd5
https://pubmed.ncbi.nlm.nih.gov/34751643

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Prophage-dependent recombination drives genome structural variation and phenotypic heterogeneity in Escherichia coli O157:H7

Autor: Sue C. Tongue, James L. Bono, Stephen F. Fitzgerald, Nadejda Lupolova, Timothy J. Dallman, Sharif Shaaban, Lesley Allison, David R. Greig, David L. Gally, MK Henry, J Evans, Tom N. McNeilly

The human zoonotic pathogen Escherichia coli O157 is defined by its extensive prophage repertoire including those that encode Shiga toxin, the factor responsible for inducing life-threatening pathology in humans. As well as introducing genes that can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0addce6738441e1a48f597d0353cc933
https://doi.org/10.1101/2020.12.02.407981

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