Computational identification of transcriptional regulators in human endotoxemia.

Autor: Tung T Nguyen, Panagiota T Foteinou, Steven E Calvano, Stephen F Lowry, Ioannis P Androulakis

Publikováno v: PLoS ONE, Vol 6, Iss 5, p e18889 (2011)

One of the great challenges in the post-genomic era is to decipher the underlying principles governing the dynamics of biological responses. As modulating gene expression levels is among the key regulatory responses of an organism to changes in its e

Externí odkaz: https://doaj.org/article/b66c903e877748feba47ff515477b107

In silico simulation of corticosteroids effect on an NFkB- dependent physicochemical model of systemic inflammation.

Autor: Panagiota T Foteinou, Steve E Calvano, Stephen F Lowry, Ioannis P Androulakis

Publikováno v: PLoS ONE, Vol 4, Iss 3, p e4706 (2009)

During the onset of an inflammatory response signaling pathways are activated for "translating" extracellular signals into intracellular responses converging to the activation of nuclear factor (NF)-kB, a central transcription factor in driving the i

Externí odkaz: https://doaj.org/article/86bc08dc5afe4354b4b5fb0c2368b904

Pretreatment with a 55-kDa Tumor Necrosis Factor Receptor-Immunoglobulin Fusion Protein Attenuates Activation of Coagulation, but not of Fibrinolysis, during Lethal Bacteremia in Baboons

Autor: Hansruedi Loetscher, Stephen F. Lowry, P. M. Jansen, Werner Lesslauer, Lyle L. Moldawer, Tom van der Poll, Hester S. A. Oldenburg, Kimberly J. Van Zee, C. Erik Hack

Publikováno v: van der Poll, T, Jansen, P G M, van Zee, K J, Hack, C E, Oldenburg, H A, Loetscher, H, Lesslauer, W, Lowry, S F & Moldawer, L L 1997, ' Pretreatment with a 55-kDa tumor necrosis factor receptor-immunoglobulin fusion protein attenuates activation of coagulation but not of fibrinolysis during lethal bacteremia in baboons ', Journal of Infectious Diseases, vol. 176, pp. 296-299 . https://doi.org/10.1086/514034
The Journal of Infectious Diseases, 176, 296-299. Oxford University Press
Journal of infectious diseases, 176(1), 296-299. Oxford University Press
Journal of Infectious Diseases, 176, 296-299. Oxford University Press

Baboons (Papio anubis) receiving a lethal intravenous infusion with live Escherichia coli were pretreated with either a 55-kDa tumor necrosis factor (TNF) receptor-IgG fusion protein (TNFR55:IgG) (n = 4, 4.6 mg/kg) or placebo (n = 4). Neutralization

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76a5d9cc73c980cec34d85aca3feb2f2
http://doc.rero.ch/record/301013/files/176-1-296.pdf

Genomic responses in mouse models poorly mimic human inflammatory diseases

Autor: Nicole S. Gibran, G. Cuenca Alex, Grace P. McDonald-Smith, Ernest E. Moore, Bernard H. Brownstein, Seok Junhee Seok, Paul E. Bankey, Philip H. Mason, Joseph P. Minei, Daniel R. Richards, Stephen F. Lowry, Carol L. Miller-Graziano, David N. Herndon, Ronald V. Maier, V. Baker Henry, Lyle L. Moldawer, Richard L. Gamelli, J. Perren Cobb, Jason L. Sperry, Shari Honari, Jeffrey L. Johnson, Steve E. Calvano, Wenzhong Xiao, Cecilia M Lopez, Michael West, Marc G. Jeschke, Celeste C. Finnerty, Joseph Cuschieri, Hong Gao, Shaw Warren, Ronald W. Davis, Timothy R. Billiar, Laura Hennessy, Matthew B. Klein, Avery B. Nathens, Ronald G. Tompkins, N. Mindrinos Michael, Laurence G. Rahme, Weihong Xu

Publikováno v: Proceedings of the National Academy of Sciences. 110:3507-3512

A cornerstone of modern biomedical research is the use of mouse models to explore basic pathophysiological mechanisms, evaluate new therapeutic approaches, and make go or no-go decisions to carry new drug candidates forward into clinical trials. Syst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::046276171995a665bec5d24d24c6dde6
https://doi.org/10.1073/pnas.1222878110

A genomic storm in critically injured humans

Autor: Michael West, S. Lowry, J. Sperry, Celeste C. Finnerty, J. Cuschieri, P. Mason, Daniel G. Remick, Shaw Warren, Michael N. Mindrinos, L. Moldawer, Henry V. Baker, Grace P. McDonald-Smith, Lily L. Altstein, B. Brownstein, Philip H. Mason, H. Baker, T. Billiar, R. Tompkins, M. Jeschke, Jeffrey L. Johnson, Ronald W. Davis, Mehmet Toner, Doug Hayden, Wing Hung Wong, Douglas L. Hayden, Richard L. Gamelli, David G. Camp, Yuping Zhang, Richard D. Smith, Nicole S. Gibran, D. Herndon, Roger J. Davis, John D. Storey, Alex G. Cuenca, Ronald V. Maier, David A. Schoenfeld, Jason L. Sperry, M. Lopez, A. Nathens, Joseph P. Minei, J. Seok, Ulysses J. Balis, J. P. Cobb, M. Klein, David N. Herndon, Wenzhong Xiao, G. McDonald-Smith, Paul E. Bankey, Joseph Cuschieri, Bruce A. McKinley, J. Minei, Marc G. Jeschke, N. Gibran, Bram Wispelwey, Steven E. Calvano, Timothy R. Billiar, Laura Hennessy, D. Schoenfeld, L. Hennessy, A. Cuenca, J. Storey, Junhee Seok, H. Shaw Warren, J. Perren Cobb, K. De Asit, Matthew B. Klein, R. Gamelli, R. Maier, P. Bankey, Michael B. Shapiro, Grant E. O'Keefe, Carol L. Miller-Graziano, M. Cecilia Lopez, Avery B. Nathens, M. Mindrinos, Hong Gao, Bernard H. Brownstein, S. Calvano, Shari Honari, Ronald G. Tompkins, C. Finnerty, Ernest E. Moore, E. Moore, Lyle L. Moldawer, J. Johnson, M. West, Robert Tibshirani, Laurence G. Rahme, Weihong Xu, Brett D. Arnoldo, Frederick A. Moore, H. Gao, Stephen F. Lowry, B. Arnoldo, W. Xiao, Brian G. Harbrecht

Publikováno v: The Journal of Experimental Medicine

Critical injury in humans induces a genomic storm with simultaneous changes in expression of innate and adaptive immunity genes.
Human survival from injury requires an appropriate inflammatory and immune response. We describe the circulating leu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9791ea55ca1348aadb4e375e9da8246a
https://doi.org/10.1084/jem.20111354