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pro vyhledávání: '"Stephen E. deLaszlo"'
Autor:
Richard A. Mumford, William K. Hagmann, Karen Owens, Plato A. Magriotis, Gail Van Riper, David N. Young, Ermengilda McCauley, Sharon Tong, Linus S. Lin, Usha Kidambi, Stephen E. deLaszlo, Ralph A. Stearns, John A. Schmidt, Adria Colletti, Yohannes Teffera, Kathryn A. Lyons, Malcolm MacCoss, Linda A. Egger, Dorothy Levorse, Thomas J. Lanza, Ihor E. Kopka, Stella H. Vincent, Sander G. Mills
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:2415-2418
A series of substituted N-(3,5-dichlorobenzenesulfonyl)-( l )-prolyl- and ( l )-azetidyl-β-biaryl β-alanine derivatives was prepared as selective and potent VLA-4 antagonists. The 2,6-dioxygenated biaryl substitution pattern is important for optimi