Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Stephen E. Moss"'
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
The establishment of new blood vessels, and their subsequent stabilization, is a critical process that facilitates tissue growth and organ development. Once established, vessels need to diversify to meet the specific needs of the local tissue and to
Externí odkaz:
https://doaj.org/article/d74c5d8a7e6149f198fd5b880c0fddc2
Autor:
Athina Dritsoula, Laura Dowsett, Camilla Pilotti, Marie N. O’Connor, Stephen E. Moss, John Greenwood
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Leucine-rich α-2-glycoprotein 1 (LRG1) is a secreted glycoprotein that under physiological conditions is produced predominantly by the liver. In disease, its local induction promotes pathogenic neovascularisation while its inhibition leads
Externí odkaz:
https://doaj.org/article/1a2cbf8d2f2644c7a2d7e5400e597c35
Publikováno v:
Journal of Biomedical Science, Vol 29, Iss 1, Pp 1-29 (2022)
Abstract The secreted glycoprotein leucine-rich α-2 glycoprotein 1 (LRG1) was first described as a key player in pathogenic ocular neovascularization almost a decade ago. Since then, an increasing number of publications have reported the involvement
Externí odkaz:
https://doaj.org/article/c04da7f00bdc4bb3bdbdfab9bd1d62f1
Autor:
Athina Dritsoula, Laura Dowsett, Camilla Pilotti, Marie N. O’Connor, Stephen E. Moss, John Greenwood
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/246231a7bfe54c19851fdf862fe84300
Autor:
Lucia Mundo, Gian Marco Tosi, Stefano Lazzi, Grazia Pertile, Barbara Parolini, Giovanni Neri, Matteo Posarelli, Elena De Benedetto, Tommaso Bacci, Ennio Silvestri, Maria Chiara Siciliano, Stefano Barbera, Maurizio Orlandini, John Greenwood, Stephen E. Moss, Federico Galvagni
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 16, p 8879 (2021)
Leucine-rich a-2-glycoprotein 1 (LRG1) is a candidate therapeutic target for treating the neovascular form of age-related macular degeneration (nvAMD). In this study we examined the expression of LRG1 in eyes of nvAMD patients. Choroidal neovascular
Externí odkaz:
https://doaj.org/article/8eba60aa9f524468b6af39d367242a55
Autor:
Katharina Lueck, Amanda-Jayne F. Carr, Dimitrios Stampoulis, Volker Gerke, Ursula Rescher, John Greenwood, Stephen E. Moss
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract The retinoic acid derivative fenretinide (FR) is capable of transdifferentiating cultured retinal pigment epithelial (RPE) cells towards a neuronal-like phenotype, but the underlying mechanisms are not understood. To identify genes involved
Externí odkaz:
https://doaj.org/article/51d55e5e3165498991da240361a0634b
Publikováno v:
International Journal of Cell Biology, Vol 2012 (2012)
Annexins are a family of calcium- and phospholipid-binding proteins found in nearly all eukaryotes. They are structurally highly conserved and have been implicated in a wide range of cellular activities. In this paper, we focus on Annexin A2 (AnxA2).
Externí odkaz:
https://doaj.org/article/b804bd41175d406cb4b3a3665452698b
Autor:
Shazeen M. Hasan, Anthony A. Vugler, Erik A. Miljan, John D. Sinden, Stephen E. Moss, John Greenwood
Publikováno v:
Cell Transplantation, Vol 19 (2010)
Human fetal retinal cells have been widely advocated for the development of cellular replacement therapies in patients with retinal dystrophies and age-related macular degeneration. A major limitation, however, is the lack of an abundant and renewabl
Externí odkaz:
https://doaj.org/article/768ced2a048b4564b8158d38f73bff68
Autor:
Carlotta Camilli, Vijay Chudasama, Faiza Javaid, Calise Bahou, Stephen E. Moss, John Greenwood, Jack W.D. Blackburn, Camilla Pilotti, David Kallenberg, James R. Baker
Publikováno v:
RSC Chemical Biology
Leucine-rich alpha-2-glycoprotein 1 (LRG1) is present abundantly in the microenvironment of many tumours where it contributes to vascular dysfunction, which impedes the delivery of therapeutics. In this work we demonstrate that LRG1 is predominantly
Autor:
Jian Liu, Andrew D. Dick, Stephen E. Moss, Sofia Theodoropoulou, Alison J. Clare, Christopher R. Neal, Lindsay B. Nicholson, David A. Copland
Publikováno v:
Journal of Cellular and Molecular Medicine
Clare, A J, Copland, D A, Nicholson, L B, Liu, J, Neal, C R, Moss, S, Dick, A D & Theodoropoulou, S 2020, ' Treatment with interleukin-33 is non-toxic and protects retinal pigment epithelium in an ageing model of outer retinal degeneration ', Journal of Cellular and Molecular Medicine . https://doi.org/10.1111/jcmm.16000
Clare, A J, Copland, D A, Nicholson, L B, Liu, J, Neal, C R, Moss, S, Dick, A D & Theodoropoulou, S 2020, ' Treatment with interleukin-33 is non-toxic and protects retinal pigment epithelium in an ageing model of outer retinal degeneration ', Journal of Cellular and Molecular Medicine . https://doi.org/10.1111/jcmm.16000
The leading cause of central vision loss, age‐related macular degeneration (AMD), is a degenerative disorder characterized by atrophy of retinal pigment epithelium (RPE) and photoreceptors. For 15% of cases, neovascularization occurs, leading to ac