Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Stephen E. McGowan"'
Autor:
Stephen E. McGowan, Diann M. McCoy
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 320:L179-L192
Platelet-derived growth factor receptor-α (PDGFRα) is absolutely required for the development of secondary pulmonary alveolar septa. Our earlier observations indicated that PDGFRα resides intracellularly as well as on the plasma membrane of murine
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 62:454-465
During pulmonary secondary alveolar septation, the rudimentary distal saccule subdivides by extending tissue sheets into the saccular air space, creating alveoli, which open into the alveolar duct. The sheets originate from saccular mesenchymal cells
Publikováno v:
Regenerative Medicine. 13:889-915
Aim: A virus- and oncogene-free induced pluripotent stem cell (iPSC) reprogramming method was developed with cord blood-derived mononuclear cells (CBDMNC) and peripheral blood mononuclear cells (PBMNC) from patients with genetic lung diseases. Method
Autor:
Diann M. McCoy, Stephen E. McGowan
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 315:L102-L115
Generation of secondary alveolar septa occurs primarily after birth in humans and is complete in mice postnatally, when mechanical stresses vary as air space pressure oscillates. Alveolar mesenchymal cells deposit elastic fibers, which limit cell str
Autor:
Diann M. McCoy, Stephen E. McGowan
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 313:L1174-L1187
Platelet-derived growth factor (PDGF)-A, which only signals through PDGF-receptor-α (PDGFR-α), is required for secondary alveolar septal formation. Although PDGFR-α distinguishes mesenchymal progenitor cells during the saccular stage, PDGFR-α-exp
Autor:
Stephen E. McGowan
Publikováno v:
Cell and Tissue Research. 367:707-719
Although pulmonary alveolar interstitial fibroblasts are less specialized than their epithelial and endothelial neighbors, they play essential roles during development and in response to lung injury. At birth, they must adapt to the sudden mechanical
Autor:
Stephen E. McGowan
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
Transcription factor 21 (Tcf21) is a basic helix-loop-helix transcription factor required for mesenchymal development in several organs. Others have demonstrated that Tcf21 is expressed in embryonic lung mesenchyme and that loss of Tcf21 results in a
Autor:
Diann M. McCoy, Stephen E. McGowan
Publikováno v:
American journal of respiratory cell and molecular biology. 57(1)
Glucocorticoids have been widely used and exert pleiotropic effects on alveolar structure and function, but do not improve the long-term clinical outcomes for patients with bronchopulmonary dysplasia, emphysema, or interstitial lung diseases. Treatme
Autor:
Stephen E. McGowan
Publikováno v:
Birth Defects Research Part A: Clinical and Molecular Teratology. 100:227-239
Alveolar development in humans primarily occurs postnatally and requires a carefully orchestrated expansion of distal epithelial and mesenchymal progenitor populations and coordinated differentiation, to create a highly segmented gas-exchange surface
Autor:
Diann M. McCoy, Stephen E. McGowan
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 305:L229-L239
Alveolar septal formation is required to support the respiration of growing mammals; in humans effacement of the alveolar surface and impaired gas exchange are critical features of emphysema and pulmonary fibrosis. Platelet-derived growth factor-A (P