Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Stephen E. Leonard"'
Autor:
Gregory J Crowther, Heidi K Hillesland, Katelyn R Keyloun, Molly C Reid, Maria Jose Lafuente-Monasterio, Sonja Ghidelli-Disse, Stephen E Leonard, Panqing He, Jackson C Jones, Mallory M Krahn, Jack S Mo, Kartheek S Dasari, Anna M W Fox, Markus Boesche, Majida El Bakkouri, Kasey L Rivas, Didier Leroy, Raymond Hui, Gerard Drewes, Dustin J Maly, Wesley C Van Voorhis, Kayode K Ojo
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0149996 (2016)
In 2010 the identities of thousands of anti-Plasmodium compounds were released publicly to facilitate malaria drug development. Understanding these compounds' mechanisms of action--i.e., the specific molecular targets by which they kill the parasite-
Externí odkaz:
https://doaj.org/article/5e2950d857f248d1802b59df2efcbcbc
Publikováno v:
Biochemistry
Src-family kinases (SFKs) make up a family of nine homologous multidomain tyrosine kinases whose misregulation is responsible for human disease (cancer, diabetes, inflammation, etc.). Despite overall sequence homology and identical domain architectur
Autor:
Wesley C. Van Voorhis, Kayode K. Ojo, Stefan H. I. Kappe, Mark Kennedy, Katelyn R. Keyloun, Steven M. Johnson, Erkang Fan, Tiffany Silver-Brace, Arinjay K. Mitra, Christophe L. M. J. Verlinde, Jen C. C. Hume, Zhongsheng Zhang, Ethan A. Merritt, Anna M. W. Fox, Stephen E. Leonard, Molly C. Reid, Dustin J. Maly, Ryan Choi, Rama Subba Rao Vidadala
Publikováno v:
European Journal of Medicinal Chemistry. 74:562-573
Malaria remains a major health concern for a large percentage of the world's population. While great strides have been made in reducing mortality due to malaria, new strategies and therapies are still needed. Therapies that are capable of blocking th
Autor:
Eric T. Larson, Pratistha Ranjitkar, Stephen E. Leonard, Ethan A. Merritt, Dustin J. Maly, Ratika Krishnamurty, Edward J. Dale, Jennifer L. Brigham
Publikováno v:
Nature chemical biology
Protein kinases, key regulators of intracellular signal transduction, have emerged as an important class of drug targets. Chemical proteomic tools that facilitate the functional interrogation of protein kinase active sites are powerful reagents for s
Autor:
Tessa J. Barrett, Kate S. Carroll, Stephen E. Leonard, David I. Pattison, Michael J. Davies, Clare L. Hawkins
Publikováno v:
Free Radical Biology and Medicine. 52:1075-1085
Myeloperoxidase (MPO) forms reactive oxidants including hypochlorous and hypothiocyanous acids (HOCl and HOSCN) under inflammatory conditions. HOCl causes extensive tissue damage and plays a role in the progression of many inflammatory-based diseases
Publikováno v:
Angewandte Chemie International Edition. 50:4423-4427
Mining the Thiol Proteome for Sulfenic Acid Modifications Reveals New Targets for Oxidation in Cells
Publikováno v:
ACS Chemical Biology. 4:783-799
Oxidation of cysteine to sulfenic acid has emerged as a biologically relevant post-translational modification with particular importance in redox- mediated signal transduction; however, the identity of modified proteins remains largely unknown. We re
Autor:
Jack S. Mo, Sonja Ghidelli-Disse, Majida El Bakkouri, Gerard Drewes, Mallory M. Krahn, Jackson C. Jones, Kasey Rivas, Katelyn R. Keyloun, Kartheek S. Dasari, Wesley C. Van Voorhis, Maria Jose Lafuente-Monasterio, Stephen E. Leonard, Dustin J. Maly, Panqing He, Kayode K. Ojo, Heidi K. Hillesland, Didier Leroy, Raymond Hui, Gregory J. Crowther, Markus Boesche, Molly C. Reid, Anna M. W. Fox
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 3, p e0149996 (2016)
PLoS ONE, Vol 11, Iss 3, p e0149996 (2016)
In 2010 the identities of thousands of anti-Plasmodium compounds were released publicly to facilitate malaria drug development. Understanding these compounds' mechanisms of action--i.e., the specific molecular targets by which they kill the parasite-
Autor:
Dustin J. Maly, Ratika Krishnamurty, Gabriel J. Brighty, Ames C. Register, Stephen E. Leonard
Publikováno v:
ACS Chemical Biology
Multidomain protein kinases, central controllers of signal transduction, use regulatory domains to modulate catalytic activity in a complex cellular environment. Additionally, these domains regulate noncatalytic functions, including cellular localiza
Publikováno v:
The FASEB Journal. 27