Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Stephen E. Kurtz"'
Autor:
Alan S. Futran, Tao Lu, Katherine Amberg-Johnson, Jiayi Xu, Xiaoxiao Yang, Saidi He, Sarah Boyce, Jeffrey A. Bell, Robert Pelletier, Takao Suzuki, Xianhai Huang, Heng Qian, Liping Fang, Li Xing, Zhaowu Xu, Stephen E. Kurtz, Jeffrey W. Tyner, Wayne Tang, Tao Guo, Karen Akinsanya, David Madge, Kristian K. Jensen
Publikováno v:
iScience, Vol 27, Iss 5, Pp 109693- (2024)
Summary: The USP7 deubiquitinase regulates proteins involved in the cell cycle, DNA repair, and epigenetics and has been implicated in cancer progression. USP7 inhibition has been pursued for the development of anti-cancer therapies. Here, we describ
Externí odkaz:
https://doaj.org/article/ad0bc59a163a477bae0474b6a3ff6a2d
Autor:
Elana Thieme, Tingting Liu, Nur Bruss, Carly Roleder, Vi Lam, Xiaoguang Wang, Tamilla Nechiporuk, Geoffrey Shouse, Olga V. Danilova, Daniel Bottomly, Shannon K. McWeeney, Jeffrey W. Tyner, Stephen E. Kurtz, Alexey V. Danilov
Publikováno v:
Cell Death and Disease, Vol 13, Iss 3, Pp 1-11 (2022)
Abstract Aberrant B-cell receptor (BCR) signaling is a key driver in lymphoid malignancies. Bruton tyrosine kinase (BTK) inhibitors that disrupt BCR signaling have received regulatory approvals in therapy of mantle cell lymphoma (MCL). However, respo
Externí odkaz:
https://doaj.org/article/6ba6538ef93547b086ba5fe9d9f53329
Autor:
Brian S. White, Suleiman A. Khan, Mike J. Mason, Muhammad Ammad-ud-din, Swapnil Potdar, Disha Malani, Heikki Kuusanmäki, Brian J. Druker, Caroline Heckman, Olli Kallioniemi, Stephen E. Kurtz, Kimmo Porkka, Cristina E. Tognon, Jeffrey W. Tyner, Tero Aittokallio, Krister Wennerberg, Justin Guinney
Publikováno v:
npj Precision Oncology, Vol 5, Iss 1, Pp 1-11 (2021)
Abstract The FDA recently approved eight targeted therapies for acute myeloid leukemia (AML), including the BCL-2 inhibitor venetoclax. Maximizing efficacy of these treatments requires refining patient selection. To this end, we analyzed two recent A
Externí odkaz:
https://doaj.org/article/f6bd5ff98ce1490bb82d669c7207b895
Autor:
Alisa Damnernsawad, Daniel Bottomly, Stephen E. Kurtz, Christopher A. Eide, Shannon K. McWeeney, Jeffrey W. Tyner, Tamilla Nechiporuk
Publikováno v:
Haematologica, Vol 107, Iss 1 (2020)
Drug resistance impedes the long-term effect of targeted therapies in acute myeloid leukemia (AML), necessitating the identification of mechanisms underlying resistance. Approximately 25% of AML patients carry FLT3 mutations and develop post-treatmen
Externí odkaz:
https://doaj.org/article/77ae0d83a6244d158ead1609052ab16a
Autor:
Stephen E. Kurtz, Jeffrey W. Tyner
Publikováno v:
Haematologica, Vol 105, Iss 6 (2020)
Externí odkaz:
https://doaj.org/article/bca8fea3c81042edba5aa3885a8b3aa7
Autor:
Jeffrey W. Tyner, Shannon K McWeeney, Bill H. Chang, Brian J. Druker, Alexey V. Danilov, Cristina E. Tognon, Mara Rosenberg, Sunil K. Joshi, Amanda d'Almeida, Rachel Culp-Hill, Angelo D'Alessandro, Courtney L. Jones, Tingting Liu, Olga Nikolova, Stephen E. Kurtz, Tamilla Nechiporuk
Complete methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01469889e6c7cd5bc22844d7ac585f37
https://doi.org/10.1158/2159-8290.22536121.v1
https://doi.org/10.1158/2159-8290.22536121.v1
Autor:
Jeffrey W. Tyner, Shannon K McWeeney, Bill H. Chang, Brian J. Druker, Alexey V. Danilov, Cristina E. Tognon, Mara Rosenberg, Sunil K. Joshi, Amanda d'Almeida, Rachel Culp-Hill, Angelo D'Alessandro, Courtney L. Jones, Tingting Liu, Olga Nikolova, Stephen E. Kurtz, Tamilla Nechiporuk
Dose response curve analyses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce2b5c702ee40ea69e999235e9edf717
https://doi.org/10.1158/2159-8290.22536133.v1
https://doi.org/10.1158/2159-8290.22536133.v1
Autor:
Jeffrey W. Tyner, Shannon K McWeeney, Bill H. Chang, Brian J. Druker, Alexey V. Danilov, Cristina E. Tognon, Mara Rosenberg, Sunil K. Joshi, Amanda d'Almeida, Rachel Culp-Hill, Angelo D'Alessandro, Courtney L. Jones, Tingting Liu, Olga Nikolova, Stephen E. Kurtz, Tamilla Nechiporuk
Confirmation of CRISPR KOs in MOLM13, MV4;11 and OCI-AML2 cells and additional apoptotic protein profiles in MOLM13 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ac6e828fb0281da57837896ed087b80
https://doi.org/10.1158/2159-8290.22536142
https://doi.org/10.1158/2159-8290.22536142
Autor:
Jeffrey W. Tyner, Brian J. Druker, Shannon K. McWeeney, Beth Wilmot, Daniel Bottomly, Pierrette Lo, Stephen E. Kurtz, Andrea Local, Nasrin Rastgoo, Hongying Zhang, Stephen B. Howell, William G. Rice
Supplementary Table from Luxeptinib (CG-806) Targets FLT3 and Clusters of Kinases Operative in Acute Myeloid Leukemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a397862d7233705acf11f41803a0be4
https://doi.org/10.1158/1535-7163.22523650.v1
https://doi.org/10.1158/1535-7163.22523650.v1
Autor:
Jeffrey W. Tyner, Shannon K McWeeney, Bill H. Chang, Brian J. Druker, Alexey V. Danilov, Cristina E. Tognon, Mara Rosenberg, Sunil K. Joshi, Amanda d'Almeida, Rachel Culp-Hill, Angelo D'Alessandro, Courtney L. Jones, Tingting Liu, Olga Nikolova, Stephen E. Kurtz, Tamilla Nechiporuk
Global metabolomics profile of AML patient samples with WT or mutant TP53 status.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be1c1e428cc087e573c9339db69ad887
https://doi.org/10.1158/2159-8290.22536136.v1
https://doi.org/10.1158/2159-8290.22536136.v1