Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Stephen E. Follansbee"'
Autor:
Hans Ulrich Burger, Donna Mildvan, Martin S. Hirsch, Lucille Donatacci, M. John Gill, Stephen E. Follansbee, Douglas D. Richman, Jacob Lalezari, Richard Haubrich, Miklos Salgo, Doreen Beattie
Publikováno v:
Antiviral Therapy. 3:33-42
The objective of this randomized, double-blind, controlled multicentre study was to evaluate the efficacy of saquinavir alone or in combination with zalcitabine compared to zalcitabine monotherapy in reducing progression of human immunodeficiency vir
Autor:
Stephen E. Follansbee, W. Lawrence Drew, Jacob Lalezari, R C Miner, Gail I. Marousek, Susan Guentzel, Sunwen Chou, Margaret E. Poscher
Publikováno v:
The Journal of Infectious Diseases. 176:786-789
In a human immunodeficiency virus-infected subject, cytomegalovirus (CMV) isolated 9 months after the patient began oral ganciclovir prophylaxis was resistant to ganciclovir and cidofovir and contained mutations in both UL97 and Pol coding regions. A
Autor:
Stephen E. Follansbee, Dragana Jekic-McMullen, Janice A. Kolberg, Lu-Ping Shen, Jennifer Flood, Margaret E. Poscher, Janice Garve, R C Miner, W L Drew
Publikováno v:
The Journal of Infectious Diseases. 176:348-352
Branched chain DNA assay (bDNA), cytomegalovirus (CMV) antigen assay, and cerebrospinal fluid (CSF) viral culture were studied for their utility in the diagnosis of CMV polyradiculopathy and for documenting in vivo antiviral effects. CMV was demonstr
Autor:
Robert Andruczk, Jacob Lalezari, Stephen A. Spector, Mary Jean Stempien, Paula D. Sparti, Tobias Samo, George McKinley, Stephen E. Follansbee, William Buhles, Gail Simpson, Diane V. Havlir, Rodney Wong
Publikováno v:
New England Journal of Medicine. 334:1491-1497
Background In the advanced stages of the acquired immunodeficiency syndrome (AIDS), cytomegalovirus (CMV) disease, particularly vision-damaging retinitis due to CMV, is common. We evaluated prophylactic treatment with orally administered ganciclovir
Publikováno v:
Clinical Therapeutics. 18:546-558
This prospective, clinical economic study was done to determine the cost impact of oral compared with intravenous (IV) ganciclovir for the maintenance treatment of newly diagnosed cytomegalovirus (CMV) retinitis in patients with acquired immunodefici
Autor:
W. Lawrence Drew, David Ives, Jacob P. Lalezari, Clyde Crumpacker, Stephen E. Follansbee, Stephen A. Spector, Constance A. Benson, Dorothy N. Friedberg, Larry Hubbard, Mary Jean Stempien, Anna Shadman, William Buhles
Publikováno v:
New England Journal of Medicine. 333:615-620
Background Cytomegalovirus retinitis, a sight-threatening infection associated with the acquired immunodeficiency syndrome (AIDS), currently requires lifelong intravenous treatment. An effective oral treatment would be an important advance. Methods W
Autor:
Kathryn Squires, Barbara Mastre, W. Lawrence Drew, James D. Connor, Donald Jung, David F. Busch, Stephen E. Follansbee, Anna Shadman, Jacob Lalezari, Stephen A. Spector, William Buhles, Mark A. Jacobson
Publikováno v:
Journal of Infectious Diseases. 171:1431-1437
A phase I/II study evaluated the pharmacokinetics, tolerability, and antiviral activity of oral ganciclovir in persons infected with human immunodeficiency virus (HIV). Oral bioavailability ranged from 2.6% to 7.3%. The mean maximum serum concentrati
Autor:
John Gullett, Bernadette DeArmond, Stephen E. Follansbee, Thomas R. Matthews, William Buhles, Shelly M. Gordon, Steven G. Mehalko, William F. Owen, W. Lawrence Drew, R C Miner, David F. Busch
Publikováno v:
Journal of Infectious Diseases. 163:716-719
Seventy-two AIDS patients treated with ganciclovir for cytomegalovirus (CMV) disease were prospectively monitored for the development of drug-resistant virus. No resistant strains were found in 31 patients before therapy or among seven culture-positi
Publikováno v:
Journal of Infectious Diseases. 161:1078-1084
Mucocutaneous herpes simplex virus (HSV) infections that are resistant to therapy with acyclovir have been recognized with increasing frequency in patients with the acquired immunodeficiency syndrome, although alternative therapies in this setting ha