Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Stephen E. Flaherty"'
Autor:
John D. Griffin, Joanne M. Buxton, Jeffrey A. Culver, Robert Barnes, Emily A. Jordan, Alexis R. White, Stephen E. Flaherty, Barbara Bernardo, Trenton Ross, Kendra K. Bence, Morris J. Birnbaum
Publikováno v:
Molecular Metabolism, Vol 78, Iss , Pp 101830- (2023)
Objective: The liver is a central regulator of energy metabolism exerting its influence both through intrinsic processing of substrates such as glucose and fatty acid as well as by secreting endocrine factors, known as hepatokines, which influence me
Externí odkaz:
https://doaj.org/article/c24bdc42ed0a49f18fde932dcb90408d
Autor:
Stephen E. Flaherty, Olivier Bezy, Wei Zheng, Dong Yan, Xiangping Li, Srinath Jagarlapudi, Bina Albuquerque, Ryan M. Esquejo, Matthew Peloquin, Meriem Semache, Arturo Mancini, Liya Kang, Doreen Drujan, Susanne B. Breitkopf, John D. Griffin, Pierre M. Jean Beltran, Liang Xue, John Stansfield, Evanthia Pashos, Quazi Shakey, Christian Pehmøller, Mara Monetti, Morris J. Birnbaum, Jean-Philippe Fortin, Zhidan Wu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Urocortin 2 (UCN2) acts as a ligand for the G protein-coupled receptor corticotropin-releasing hormone receptor 2 (CRHR2). UCN2 has been reported to improve or worsen insulin sensitivity and glucose tolerance in vivo. Here we show that acute
Externí odkaz:
https://doaj.org/article/c30f771320644d0bb5638ece93bbd9e2
Autor:
Melissa J. Chee, Alex J. Hebert, Nadege Briançon, Stephen E. Flaherty, III, Pavlos Pissios, Eleftheria Maratos-Flier
Publikováno v:
Molecular Metabolism, Vol 29, Iss , Pp 114-123 (2019)
Objective: Melanin-concentrating hormone (MCH) plays a key role in regulating energy balance. MCH acts via its receptor MCHR1, and MCHR1 deletion increases energy expenditure and locomotor activity, which is associated with a hyperdopaminergic state.
Externí odkaz:
https://doaj.org/article/0217db779a2b4196b7577607ab8f8b6c
Autor:
Alex J. Hebert, Melissa J. Chee, Eleftheria Maratos-Flier, Nadege Briançon, Pavlos Pissios, Stephen E. Flaherty
Publikováno v:
Molecular Metabolism, Vol 29, Iss, Pp 114-123 (2019)
Molecular Metabolism
Molecular Metabolism
Objective Melanin-concentrating hormone (MCH) plays a key role in regulating energy balance. MCH acts via its receptor MCHR1, and MCHR1 deletion increases energy expenditure and locomotor activity, which is associated with a hyperdopaminergic state.
Publikováno v:
Expert Review of Endocrinology & Metabolism. 10:413-424
Our knowledge of whole organism physiology has greatly advanced in the past decades through mouse genetics. In particular, genetic studies have revealed that most organs interact with one another through hormones in order to maintain normal physiolog
Autor:
Stephen E. Flaherty, Andrew C. Adams, Shuangyu Lu, Nicholas Douris, Eleftheria Maratos-Flier, Avery B. Forrow, Melissa J. Chee, Arnaud Monnard
Olanzapine (OLZ), an atypical antipsychotic, can be effective in treating patients with restricting type anorexia nervosa who exercise excessively. Clinical improvements include weight gain and reduced pathological hyperactivity. However the neuronal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad20bd6e96e74bef866102fa3984dcd2
https://europepmc.org/articles/PMC4609648/
https://europepmc.org/articles/PMC4609648/
Autor:
Stephen E Flaherty III, Olivier Bezy, Brianna LaCarubba Paulhus, LouJin Song, Mary Piper, Jincheng Pang, Yoson Park, Shoh Asano, Yu-Chin Lien, John D Griffin, Andrew Robertson, Alan Opsahl, Dinesh Hirenallur Shanthappa, Youngwook Ahn, Evanthia Pashos, Rebecca A Simmons, Morris J Birnbaum, Zhidan Wu
Publikováno v:
eLife, Vol 12 (2024)
From a forward mutagenetic screen to discover mutations associated with obesity, we identified mutations in the Spag7 gene linked to metabolic dysfunction in mice. Here, we show that SPAG7 KO mice are born smaller and develop obesity and glucose into
Externí odkaz:
https://doaj.org/article/4c48137f953943ab9ab7d2ee4fda5031