Zobrazeno 1 - 10
of 232
pro vyhledávání: '"Stephen E Webber"'
Autor:
Nicola J. Curtin, Stephen E. Webber, Lan-Zhen Wang, Donald Skalitzky, David R. Newell, Karen A. Maegley, Suzanne Kyle, Zdenek Hostomsky, Stacie Canan, Michael A. Batey, Christopher R. Calabrese, Huw D. Thomas
Adobe PDF - MCT-06-0552--Suppl_Table_S1.pdf from Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0f0b3fff940d1a4cd79259b67d4afb5
https://doi.org/10.1158/1535-7163.22485801
https://doi.org/10.1158/1535-7163.22485801
Autor:
Nicola J. Curtin, Stephen E. Webber, Lan-Zhen Wang, Donald Skalitzky, David R. Newell, Karen A. Maegley, Suzanne Kyle, Zdenek Hostomsky, Stacie Canan, Michael A. Batey, Christopher R. Calabrese, Huw D. Thomas
Poly(ADP-ribose) polymerase (PARP)-1 (EC 2.4.2.30) is a nuclear enzyme that promotes the base excision repair of DNA breaks. Inhibition of PARP-1 enhances the efficacy of DNA alkylating agents, topoisomerase I poisons, and ionizing radiation. Our aim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02b1b5661cb9328ac5a8e732319794d9
https://doi.org/10.1158/1535-7163.c.6532086.v1
https://doi.org/10.1158/1535-7163.c.6532086.v1
Autor:
Stephen E. Webber, James R. Appleman
Publikováno v:
Cancer Research. 80:582-582
At Primmune, we believe that maximal therapeutic benefit in cancer immunotherapy will be achieved by maintaining sustained, systemic immune pressure involving both innate and adaptive immunity. We have therefore chosen PRX034, an orally administered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86385ab7a21dae5990e9826af129e18b
https://doi.org/10.1158/1538-7445.am2020-582
https://doi.org/10.1158/1538-7445.am2020-582
Autor:
Joan Chen, Melissa Neal, Katti Jessen, Gregory S. Parker, Reich Siegfried Heinz, Michael B. Shaghafi, Edward Z. R. Han, Ivy Nj Hung, Justin T. Ernst, James R. Appleman, Tran Chinh Viet, Qing Han, Douglas E. Murphy, Craig R. Stumpf, Christopher J. Wegerski, Vera Huang, Jolene Molter, Paul A. Sprengeler, Peggy A. Thompson, Jocelyn Staunton, Gary G. Chiang, Vikas K Goel, Jeff Clarine, Samuel Sperry, Boreth Eam, Kevin R. Webster, Adriana L. Jemison, Stephen E. Webber, Hong Zheng
Publikováno v:
Journal of medicinal chemistry. 61(8)
Dysregulated translation of mRNA plays a major role in tumorigenesis. Mitogen-activated protein kinase interacting kinases (MNK)1/2 are key regulators of mRNA translation integrating signals from oncogenic and immune signaling pathways through phosph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a04cce3bf4928b41080e47e6b530276e
https://pubmed.ncbi.nlm.nih.gov/29526098
https://pubmed.ncbi.nlm.nih.gov/29526098
Autor:
James R. Appleman, Stephen E. Webber
Publikováno v:
Cancer Research. 79:3262-3262
While ICPIs (immune checkpoint inhibitors) have fundamentally changed the practice of cancer therapy for tumors arising from many different tissues, ways to increase both response rate and durability are critically needed. On theoretical grounds, com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::401d1ec4b6841c4735d8431e144af9ff
https://doi.org/10.1158/1538-7445.am2019-3262
https://doi.org/10.1158/1538-7445.am2019-3262
Autor:
Stephen E. Webber, James R. Appleman
Publikováno v:
Journal of Clinical Oncology. 37:e14246-e14246
e14246 Background: While ICPIs (immune checkpoint inhibitors) have fundamentally changed the practice of cancer therapy for tumors arising from many different tissues, ways to increase both response rate and durability are critically needed. On theor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5a7158f38e3b4c7a9f790c00aa73957
https://doi.org/10.1200/jco.2019.37.15_suppl.e14246
https://doi.org/10.1200/jco.2019.37.15_suppl.e14246
Autor:
Laurie A. LeBrun, Mei Tsan, Yuefen Zhou, Frank Ruebsam, Darian M. Bartkowski, Alan X. Xiang, Ruhi Kamran, Lian-Sheng Li, Richard E. Showalter, Jingjing Zhao, Rupal Patel, Matthew Lardy, Maria V. Sergeeva, Stephen E. Webber, Amit M. Shah, David Archer Ellis, Zhongxiang Sun, Mcguire Helen, Julie Blazel, Leo Kirkovsky, Daniel A. Norris, Tran Chinh Viet, Charles R. Kissinger, Thomas G. Nolan, Peter S. Dragovich, Qing Han
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4628-4632
4-(1,1-Dioxo-1,4-dihydro-1lambda(6)-benzo[1,4]thiazin-3-yl)-5-hydroxy-2H-pyridazin-3-one analogs were discovered as a novel class of inhibitors of HCV NS5B polymerase. Structure-based design led to the identification of compound 3a that displayed pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11da5f58198cc1bc858c040e469b8f03
https://doi.org/10.1016/j.bmcl.2008.07.014
https://doi.org/10.1016/j.bmcl.2008.07.014
Autor:
Chun Chow, Daniel Wall, Douglas E. Murphy, Stephen E. Webber, Thomas M. Bertolini, Yuefen Zhou, Zhongxiang Sun, Thomas Hermann, Jamie M. Froelich
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:3369-3375
Translation inhibitors of the 3,5-diamino-piperidine series act as aminoglycoside mimetics that inhibit bacterial growth. Here we show antibacterial SAR in the presence and absence of serum with a particular focus towards Pseudomonas aeruginosa.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d036dfb8db9d0e1b9ba892ff9d73080a
https://doi.org/10.1016/j.bmcl.2008.04.023
https://doi.org/10.1016/j.bmcl.2008.04.023
Autor:
Tran Chinh Viet, Charles R. Kissinger, Daniel A. Norris, Ruhi Kamran, Amit M. Shah, Jingjing Zhao, Yuefen Zhou, Rupal Patel, Matthew Lardy, Darian M. Bartkowski, Richard E. Showalter, Stephen E. Webber, Laurie A. LeBrun, Mei Tsan, Douglas E. Murphy, Sun Hee Kim, Maria V. Sergeeva, Leo Kirkovsky, Martin T. Tran, Thomas G. Nolan, Qing Han, Frank Ruebsam, Lian-Sheng Li, Peter S. Dragovich
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:3616-3621
Pyrrolo[1,2-b]pyridazin-2-one analogs were discovered as a novel class of inhibitors of genotype 1 HCV NS5B polymerase. Structure-based design led to the discovery of compound 3 k, which displayed potent inhibitory activities in biochemical and repli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f4ad75b76b7814c0968de6c9e82a0a6
https://doi.org/10.1016/j.bmcl.2008.04.066
https://doi.org/10.1016/j.bmcl.2008.04.066
Autor:
Tran Chinh Viet, Douglas E. Murphy, Stephen E. Webber, Bin Li, Thomas Hermann, Zhongxiang Sun, Charles R. Kissinger, Rupal Patel, Frank Ruebsam, Maria V. Sergeeva, Peter S. Dragovich, Lian-Sheng Li, Yuefen Zhou, Richard E. Showalter, Amit M. Shah, Laurie A. LeBrun, Qing Han, Qiang Zhao, Leo Kirkovsky, Mei Tsan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:1413-1418
5-Hydroxy-3(2H)-pyridazinone derivatives were investigated as inhibitors of genotype 1 HCV NS5B polymerase. The synthesis, structure–activity relationships (SAR), metabolic stability, and structure-based design approach for this new class of compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9afbf74a4bd08648255e82b6074239c3
https://doi.org/10.1016/j.bmcl.2008.01.007
https://doi.org/10.1016/j.bmcl.2008.01.007