Zobrazeno 1 - 10
of 215
pro vyhledávání: '"Stephen E Girardin"'
Autor:
Parastoo Boroumand, David C Prescott, Tapas Mukherjee, Philip J Bilan, Michael Wong, Jeff Shen, Ivan Tattoli, Yuhuan Zhou, Angela Li, Tharini Sivasubramaniyam, Nancy Shi, Lucie Y Zhu, Zhi Liu, Clinton Robbins, Dana J Philpott, Stephen E Girardin, Amira Klip
Publikováno v:
eLife, Vol 11 (2022)
During obesity and high fat-diet (HFD) feeding in mice, sustained low-grade inflammation includes not only increased pro-inflammatory macrophages in the expanding adipose tissue, but also bone marrow (BM) production of invasive Ly6Chigh monocytes. As
Externí odkaz:
https://doaj.org/article/f814826c238d44d7839ebe163a29ca19
Publikováno v:
BioTechniques, Vol 69, Iss 4, Pp 249-256 (2020)
Mitophagy is the process by which mitochondria are selectively targeted and removed via autophagic machinery to maintain mitochondrial homeostasis in the cell. Recently, flow cytometry-based assays that utilize the fluorescent mtKeima reporter system
Externí odkaz:
https://doaj.org/article/e22e909199ca4fd4a0f1d086eeefbedc
Autor:
Angelique M L Scantlebery, Melissa Uil, Loes M Butter, Renée Poelman, Nike Claessen, Stephen E Girardin, Sandrine Florquin, Joris J T H Roelofs, Jaklien C Leemans
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0214437 (2019)
Diabetic nephropathy (DN) is a microvascular complication of diabetes mellitus that results in both tubular and glomerular injury. Low-grade inflammation and oxidative stress are two mechanisms known to drive the progression of DN. Nucleotide-binding
Externí odkaz:
https://doaj.org/article/aa81e751840d4b5cb4ae06b621f65e90
Autor:
Justin J. Meade, Sarah Stuart, Jana Neiman-Zenevich, Christian Krustev, Stephen E. Girardin, Jeremy Mogridge
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract Cleavage of the innate immune receptor NLRP1B by various microbial proteases causes the proteasomal degradation of its N-terminal fragment and the subsequent release of a C-terminal fragment that forms an inflammasome. We reported previously
Externí odkaz:
https://doaj.org/article/f8ab6aaf55e6414db21260c2820487f1
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 6 (2016)
Shigella is a Gram-negative bacterium that is responsible for shigellosis. Over the years, the study of Shigella has provided a greater understanding of how the host responds to bacterial infection, and how bacteria have evolved to effectively counte
Externí odkaz:
https://doaj.org/article/3c7fdf9c3d824a3b9218bdd09e0f3a82
Autor:
Paul Y. Bi, Samuel A. Killackey, Linus Schweizer, Damien Arnoult, Dana J. Philpott, Stephen E. Girardin
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract Mitochondrial stress inducers such as carbonyl cyanide m-chlorophenyl hydrazone (CCCP) and oligomycin trigger the DELE1-HRI branch of the integrated stress response (ISR) pathway. Previous studies performed using epitope-tagged DELE1 showed
Externí odkaz:
https://doaj.org/article/2c938dc33b884251b8cbcb518cef007c
Autor:
Casandra W Philipson, Josep Bassaganya-Riera, Monica Viladomiu, Barbara Kronsteiner, Vida Abedi, Stefan Hoops, Pawel Michalak, Lin Kang, Stephen E Girardin, Raquel Hontecillas
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137839 (2015)
Helicobacter pylori colonizes half of the world's population as the dominant member of the gastric microbiota resulting in a lifelong chronic infection. Host responses toward the bacterium can result in asymptomatic, pathogenic or even favorable heal
Externí odkaz:
https://doaj.org/article/b94f7412b6d54d75a096a5898df47a8f
Autor:
Gerben Ferwerda, Stephen E Girardin, Bart-Jan Kullberg, Lionel Le Bourhis, Dirk J de Jong, Dennis M L Langenberg, Reinout van Crevel, Gosse J Adema, Tom H M Ottenhoff, Jos W M Van der Meer, Mihai G Netea
Publikováno v:
PLoS Pathogens, Vol 1, Iss 3, Pp 279-285 (2005)
Infection with Mycobacterium tuberculosis is one of the leading causes of death worldwide. Recognition of M. tuberculosis by pattern recognition receptors is crucial for activation of both innate and adaptive immune responses. In the present study, w
Externí odkaz:
https://doaj.org/article/6488f73434ec4f34b39dffefb812df9c
Autor:
Emilie Tourneur, Sanae Ben Mkaddem, Cécilia Chassin, Marcelle Bens, Jean-Michel Goujon, Nicolas Charles, Christophe Pellefigues, Meryem Aloulou, Alexandre Hertig, Renato C Monteiro, Stephen E Girardin, Dana J Philpott, Eric Rondeau, Carole Elbim, Catherine Werts, Alain Vandewalle
Publikováno v:
PLoS Pathogens, Vol 9, Iss 1, p e1003152 (2013)
Acute pyelonephritis (APN), which is mainly caused by uropathogenic Escherichia coli (UPEC), is the most common bacterial complication in renal transplant recipients receiving immunosuppressive treatment. However, it remains unclear how immunosuppres
Externí odkaz:
https://doaj.org/article/506aee177cb24462a4fe2b3bd0f771b8
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56014 (2013)
NOD2 is an intracellular pattern recognition receptor that provides innate sensing of bacterial muramyl dipeptide by host cells, such as dendritic cells, macrophages and epithelial cells. While NOD2's role as an innate pathogen sensor is well establi
Externí odkaz:
https://doaj.org/article/76f1a4e65a6140f7b1bafd30b0cccc95