Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Stephen E Fawell"'
Autor:
Garrett W Rhyasen, Yi Yao, Jingwen Zhang, Austin Dulak, Lillian Castriotta, Kelly Jacques, Wei Zhao, Farzin Gharahdaghi, Maureen M Hattersley, Paul D Lyne, Edwin Clark, Michael Zinda, Stephen E Fawell, Gordon B Mills, Huawei Chen
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0200826 (2018)
BRD4 is a transcriptional co-activator functioning to recruit regulatory complexes to acetylated chromatin. A subset of High-grade Serous Ovarian Cancer (HGSOC) patients are typified by focal, recurrent BRD4 gene amplifications. Despite previously de
Externí odkaz:
https://doaj.org/article/8462634de4fc494185365ef6a8d1e6ce
Autor:
Robert N Booher, Harold Hatch, Brian M Dolinski, Thi Nguyen, Lauren Harmonay, Ali-Samer Al-Assaad, Mark Ayers, Michael Nebozhyn, Andrey Loboda, Heather A Hirsch, Theresa Zhang, Bin Shi, Carrie E Merkel, Minilik H Angagaw, Yaolin Wang, Brian J Long, Xianlu Q Lennon, Nathan Miselis, Vincenzo Pucci, James W Monahan, Junghoon Lee, Anna Georgieva Kondic, Eun Kyung Im, David Mauro, Rebecca Blanchard, Gary Gilliland, Stephen E Fawell, Leigh Zawel, Alwin G Schuller, Peter Strack
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e108371 (2014)
Dinaciclib is a potent CDK1, 2, 5 and 9 inhibitor being developed for the treatment of cancer. Additional understanding of antitumor mechanisms and identification of predictive biomarkers are important for its clinical development. Here we demonstrat
Externí odkaz:
https://doaj.org/article/b410584fec734e0e84be6d52d5590862
Autor:
Claire M. Patterson, Srividya B. Balachander, Iain Grant, Petar Pop-Damkov, Brian Kelly, William McCoull, Jeremy Parker, Michael Giannis, Kathryn J. Hill, Francis D. Gibbons, Edward J. Hennessy, Paul Kemmitt, Alexander R. Harmer, Sonya Gales, Stuart Purbrick, Sean Redmond, Matthew Skinner, Lorraine Graham, J. Paul Secrist, Alwin G. Schuller, Shenghua Wen, Ammar Adam, Corinne Reimer, Justin Cidado, Martin Wild, Eric Gangl, Stephen E. Fawell, Jamal Saeh, Barry R. Davies, David J. Owen, Marianne B. Ashford
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Claire Patterson et al. present the design and development of AZD0466, a drug-dendrimer conjugate, and use preclinical and mathematical models to determine the optimal release rate of the drug from the dendrimer carrier for maximal therapeutic index
Externí odkaz:
https://doaj.org/article/722de1f4d6464ec9a94bce51fe4fc356
Autor:
Jacqueline H. L. Fok, Antonio Ramos-Montoya, Mercedes Vazquez-Chantada, Paul W. G. Wijnhoven, Valeria Follia, Neil James, Paul M. Farrington, Ankur Karmokar, Sophie E. Willis, Jonathan Cairns, Jenni Nikkilä, David Beattie, Gillian M. Lamont, M. Raymond V. Finlay, Joanne Wilson, Aaron Smith, Lenka Oplustil O’Connor, Stephanie Ling, Stephen E. Fawell, Mark J. O’Connor, Simon J. Hollingsworth, Emma Dean, Frederick W. Goldberg, Barry R. Davies, Elaine B. Cadogan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
DNA-dependent protein kinase (DNA-PK) plays a major role in the DNA damage response upon double-strand break formation. Here, the authors show that the DNA-PK inhibitor AZD7648, enhances the activity of radiotherapy, chemotherapy and the PARP inhibit
Externí odkaz:
https://doaj.org/article/7547983126794fc0a17cf1c4d462a298
Autor:
Adriana E. Tron, Matthew A. Belmonte, Ammar Adam, Brian M. Aquila, Lawrence H. Boise, Elisabetta Chiarparin, Justin Cidado, Kevin J. Embrey, Eric Gangl, Francis D. Gibbons, Gareth P. Gregory, David Hargreaves, J. Adam Hendricks, Jeffrey W. Johannes, Ricky W. Johnstone, Steven L. Kazmirski, Jason G. Kettle, Michelle L. Lamb, Shannon M. Matulis, Ajay K. Nooka, Martin J. Packer, Bo Peng, Philip B. Rawlins, Daniel W. Robbins, Alwin G. Schuller, Nancy Su, Wenzhan Yang, Qing Ye, Xiaolan Zheng, J. Paul Secrist, Edwin A. Clark, David M. Wilson, Stephen E. Fawell, Alexander W. Hird
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
High expression of Mcl-1 promotes tumorigenesis and resistance to anticancer therapies. Here they report a macrocyclic molecule with high selectivity and affinity for Mcl-1 that exhibits potent anti-tumor effects as single agent and in combination wi
Externí odkaz:
https://doaj.org/article/814ff3ef6b204d84917e2b025f3e1da9
Autor:
Aatman S. Doshi, Susan Cantin, Marylens Hernandez, Srimathi Srinivasan, Sharon Tentarelli, Matthew Griffin, Yanjun Wang, Petar Pop-Damkov, Laura B. Prickett, Cecilia Kankkonen, Minhui Shen, Maryann San Martin, Song Wu, M. Paola Castaldi, Hormas Ghadially, Jeffrey Varnes, Sonya Gales, David Henry, Clare Hoover, Deanna A. Mele, Iain Simpson, Eric T. Gangl, Scott N. Mlynarski, M. Raymond V. Finlay, Lisa Drew, Stephen E. Fawell, Wenlin Shao, Alwin G. Schuller
Publikováno v:
Molecular Cancer Therapeutics. 22:630-645
Antitumor immunity can be hampered by immunosuppressive mechanisms in the tumor microenvironment, including recruitment of arginase (ARG) expressing myeloid cells that deplete l-arginine essential for optimal T-cell and natural killer cell function.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82d755494151ffe43d642a50fe0b9dc5
https://doi.org/10.1158/1535-7163.mct-22-0431
https://doi.org/10.1158/1535-7163.mct-22-0431
Autor:
Alwin G. Schuller, Wenlin Shao, Stephen E. Fawell, Lisa Drew, M. Raymond V. Finlay, Scott N. Mlynarski, Eric T. Gangl, Iain Simpson, Deanna A. Mele, Clare Hoover, David Henry, Sonya Gales, Jeffrey Varnes, Hormas Ghadially, M. Paola Castaldi, Song Wu, Maryann San Martin, Minhui Shen, Cecilia Kankkonen, Laura B. Prickett, Petar Pop-Damkov, Yanjun Wang, Matthew Griffin, Sharon Tentarelli, Srimathi Srinivasan, Marylens Hernandez, Susan Cantin, Aatman S. Doshi
Supplementary Figure 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a3d060f84133f3a377e582a99492b60
https://doi.org/10.1158/1535-7163.22758750.v1
https://doi.org/10.1158/1535-7163.22758750.v1
Autor:
Alwin G. Schuller, Wenlin Shao, Stephen E. Fawell, Lisa Drew, M. Raymond V. Finlay, Scott N. Mlynarski, Eric T. Gangl, Iain Simpson, Deanna A. Mele, Clare Hoover, David Henry, Sonya Gales, Jeffrey Varnes, Hormas Ghadially, M. Paola Castaldi, Song Wu, Maryann San Martin, Minhui Shen, Cecilia Kankkonen, Laura B. Prickett, Petar Pop-Damkov, Yanjun Wang, Matthew Griffin, Sharon Tentarelli, Srimathi Srinivasan, Marylens Hernandez, Susan Cantin, Aatman S. Doshi
Supplementary Figure 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18665fc75233d45f4d0523f70cb00720
https://doi.org/10.1158/1535-7163.22758747.v1
https://doi.org/10.1158/1535-7163.22758747.v1
Autor:
Alwin G. Schuller, Wenlin Shao, Stephen E. Fawell, Lisa Drew, M. Raymond V. Finlay, Scott N. Mlynarski, Eric T. Gangl, Iain Simpson, Deanna A. Mele, Clare Hoover, David Henry, Sonya Gales, Jeffrey Varnes, Hormas Ghadially, M. Paola Castaldi, Song Wu, Maryann San Martin, Minhui Shen, Cecilia Kankkonen, Laura B. Prickett, Petar Pop-Damkov, Yanjun Wang, Matthew Griffin, Sharon Tentarelli, Srimathi Srinivasan, Marylens Hernandez, Susan Cantin, Aatman S. Doshi
Antitumor immunity can be hampered by immunosuppressive mechanisms in the tumor microenvironment, including recruitment of arginase (ARG) expressing myeloid cells that deplete l-arginine essential for optimal T-cell and natural killer cell function.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccec8976253039fecbf30710253ac110
https://doi.org/10.1158/1535-7163.c.6611322
https://doi.org/10.1158/1535-7163.c.6611322
Autor:
Alwin G. Schuller, Wenlin Shao, Stephen E. Fawell, Lisa Drew, M. Raymond V. Finlay, Scott N. Mlynarski, Eric T. Gangl, Iain Simpson, Deanna A. Mele, Clare Hoover, David Henry, Sonya Gales, Jeffrey Varnes, Hormas Ghadially, M. Paola Castaldi, Song Wu, Maryann San Martin, Minhui Shen, Cecilia Kankkonen, Laura B. Prickett, Petar Pop-Damkov, Yanjun Wang, Matthew Griffin, Sharon Tentarelli, Srimathi Srinivasan, Marylens Hernandez, Susan Cantin, Aatman S. Doshi
Supplementary Table 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b0b686af167082c71a1e1decc2974a2
https://doi.org/10.1158/1535-7163.22758741
https://doi.org/10.1158/1535-7163.22758741